Blood organochlorine pesticide concentrations, clinical hematology and biochemistry in workers occupationally exposed to pesticides

Morgan, Donald P.; Li, Lin

doi:10.1007/bf02332069

Cited by 32 publications

(5 citation statements)

References 27 publications

(16 reference statements)

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“…Other variables affecting body burdens may be differences in metabolism with age. In the Triana studies (7,8) the blood levels of total DDT residues also increased with age, and others have made similar observations (48)(49)(50).…”

Section: Body Burdenssupporting

confidence: 52%

“…In an additional study in Sprague-Dawley rats fed 100 ppm (100 mg/kg) Aroclor 1260, in which 32 male control, 49 female control, 46 male exposed, and 47 female exposed rats were available for microscopic examination, a high incidence of well-differentiated hepatocellular carcinomas was found in female rats and a lower incidence in males (37). In addition, a few Japanese PCBs were shown earlier to cause liver tumors in rodents (38,39).…”

Section: Reproductionmentioning

confidence: 99%

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Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds

Kimbrough¹

1985

Environmental Health Perspectives

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Similar qualitative toxic effects have been observed in animals for a class of halogenated aromatic compounds, which include the halogenated biphenyls, naphthalenes, dibenzodioxins, and dibenzofurans. All of these compounds are lipid soluble and persist in the environment and in mammals. The polybrominated biphenyls (PBBs) are the most persistent. They are predominantly stored in fatty tissue; they pass the placenta and are excreted in milk. Some isomers of the halogenated biphenyls are more toxic than others. With some exceptions, the more toxic isomers are retained longer in tissues and are also the carcinogenic components of the mixture. Most of these chemicals seem to be promoters of carcinogenesis in animals rather than initiators. An array of toxic effects in laboratory animals has been ascribed to these compounds and numerous reviews summarizing this information are available. Less information is available on the human health effects of environmental and occupational exposure. Results of recent studies in animals to further elucidate the effects of these chemicals are presented, and results from some human studies conducted in the United States are reviewed.

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Section: Body Burdenssupporting

confidence: 52%

Section: Reproductionmentioning

confidence: 99%

Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds

Kimbrough¹

1985

Environmental Health Perspectives

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“…Although the results were statistically insignificant for most years, bilirubin levels were always negatively associated with serum PBB levels, as has been found in groups with exposures to other halogenated hydrocarbons. 17 However, the liver function tests performed were insensitive and nonspecific for the demonstration of a subclinical hepatic effect, if any. Polybrominated biphenyl mixtures induce microsomal enzymes in animals ls and may produce delayed liver toxicity, demonstrated by increased hepatic porphyrins.…”

Section: Discussionmentioning

confidence: 99%

Serial PBB Levels, PCB Levels, and Clinical Chemistries in Michigan’s PBB Cohort

Kreiss

Roberts

Humphrey

1982

Archives of Environmental Health: An International Journal

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Half of a cohort of 3683 Michigan residents exposed to polybrominated biphenyls (PBBs) in 1973 and 1974 had 2 serum PBB determinations at a 1- or 2-yr interval. The median decrease in serum PBB levels during both 1- and 2-yr intervals was 1 microgram/L. The geometric mean serum polychlorinated biphenyl (PCB) level (6.3 microgram/L) exceeded that of PBB (4.1 micrograms/L), although the range of PCB levels (smaller than 1-57 microgram/L) was narrower than that of PBB levels (smaller than 1-3150 micrograms/L). Mean PCB and PBB levels were higher for males, and mean PCB levels increased with age. In a subgroup with higher-than-average PBB levels, serial clinical chemistry tests during 4 different years showed no consistent significant correlation with serum PBB levels. Tests with greater sensitivity and specificity for hepatic microsomal enzyme induction and thyroid status are needed in future evaluations of the most highly exposed subgroup of the cohort.

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“…OTHER HEALTH EFFECTS Highly exposed workers have lower serum bilirubin and slightly elevated serum levels of selected liver function tests (81). The lower serum bilirubin levels are possibly due to activation of hepatic cytochrome oxidases.…”

Section: Data On Human Health Effectsmentioning

confidence: 99%

The Human Health Effects of DDT (Dichlorodiphenyltrichloroethane) and PCBS (Polychlorinated Biphenyls) and an Overview of Organochlorines in Public Health

Longnecker

Rogan

Lucier

1997

Annu. Rev. Public Health

417

205

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Organochlorines are a diverse group of persistent synthetic compounds, some of which are detectable in nearly everyone. Many organochlorines are endocrine disruptors or carcinogens in experimental assays. p,p -DDE (dichlorodiphenyldichloroethene) and PCBs (polychlorinated biphenyls) comprise the bulk of organochlorine residues in human tissues. We reviewed relevant human data cited in the 1991-1995 Medline database and elsewhere. High-level exposure to selected organochlorines appears to cause abnormalities of liver function, skin (chloracne), and the nervous system. Of more general interest, however, is evidence suggesting insidious effects of background exposure. Of particular concern is the finding of neonatal hypotonia or hyporeflexia in relation to PCB exposure. The epidemiologic data reviewed, considered in isolation, provide no convincing evidence that organochlorines cause a large excess number of cancers. A recent risk assessment

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Blood organochlorine pesticide concentrations, clinical hematology and biochemistry in workers occupationally exposed to pesticides

Cited by 32 publications

References 27 publications

Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds

Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds

Serial PBB Levels, PCB Levels, and Clinical Chemistries in Michigan’s PBB Cohort

The Human Health Effects of DDT (Dichlorodiphenyltrichloroethane) and PCBS (Polychlorinated Biphenyls) and an Overview of Organochlorines in Public Health

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