Clinical findings in workers exposed to pentachlorophenol

Klemmer, Howard W.; Wong, Lyle; Sato, Miles M.; Reichert, Erida L.; Korsak, Richard J.; Rashad, M. N.

doi:10.1007/bf01055546

Cited by 63 publications

(12 citation statements)

References 13 publications

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“…In another study enrolling 46 subjects with occupational exposure to PCP, an increased prevalence of low-grade infections and inflammations of the skin, subcutaneous tissues, eyes and upper respiratory tract mucosa has been reported. Strong to moderate statistical associations were observed between PCP exposure and increased immature leucocytes and basophils, raised plasma cholinesterase, alkaline phosphatase, IgG and uric acid, with decreased serum calcium [56]. Several studies have reported an association between diminished lymphocyte proliferative response to mitogens and exposure to PCP [46,55,57,58].…”

Section: Effects Of Environmental Estrogens On the Immune Systemmentioning

confidence: 94%

The role of environmental estrogens and autoimmunity

Chighizola

Meroni

2012

Autoimmunity Reviews

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Section: Effects Of Environmental Estrogens On the Immune Systemmentioning

confidence: 94%

The role of environmental estrogens and autoimmunity

Chighizola

Meroni

2012

Autoimmunity Reviews

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“…Incidents of low grade respiratory infections and the development of inflammation of the skin of PCP exposed workers have been reported [14]. Increased levels of Creactive protein, which is often elevated in various inflammatory disorders has also been documented [15].…”

Section: Discussionmentioning

confidence: 99%

Suppression of mouse complement activity by contaminants of technical grade pentachlorophenol

White

Anderson

1985

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Pentachlorophenol (PCP) is an antimicrobial agent used chiefly for the preservation of wood. Subchronic oral exposure (14 days) to Technical Grade PCP significantly inhibited the functional activity of female B6C3F1 mouse complement when measured in a microtiter hemolytic assay. When evaluated one day following the final exposure the highest administered dose (100 mg/kg) significantly suppressed the Classical complement pathway, the Spontaneous C1 autoactivation pathway, the Alternate pathway and the level of complement component, C3. Reconstitution studies using C5-deficient serum also demonstrated deleterious effects on this complement component. The Classical pathway was the most sensitive to Technical Grade PCP effects. Animals treated with 100 mg/kg Technical Grade PCP had CH 50 levels 30% of vehicle controls. Animals treated for 14 days and allowed a 15 day recovery period had CH 50 values 36% of control and animals which recovered for 30 days had only 52% of the complement activity of control animals. C3 recovery studies also demonstrated continued suppression on days 15 and 30 post-final exposure. Doses of 10 and 30 mg/kg did not produce the marked effects observed with the highest dose; however, a dose-dependent trend was observed for all responses. Animals treated with 100 mg/kg of EC-7, a PCP preparation with reduced amounts of contaminating dioxins and dibenzofurans, did not demonstrate detrimental effects on the complement system.

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“…PCP was used as an insecticide and fungicide [compare Klemmer et al, 1980]. Extensive published reports have described the toxic effects, resulting in a ban of PCP production and trade in 1989 in Germany.…”

Section: Introductionmentioning

confidence: 99%

Long-term exposure to wood-preserving chemicals containing pentachlorophenol and lindane is related to neurobehavioral performance in women

1999

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Background The adverse neurobehavioral effects of long‐term low exposure to wood‐preserving chemicals (WPC) containing solvents, pentachlorophenol (PCP) and γ‐hexachlorocyclohexane (γ‐HCH; lindane), and other neurotoxicants were investigated in a neuropsychological group study. Methods Out of a population of 2,000 women visiting the outpatient practice of a gynecological department, a sample of 15 women aged 31–56 (mean 43) with long‐term exposure to WPC verified by self‐report, biological monitoring, and environmental samples was investigated. Fifteen controls aged 42 (31–56) years were drawn from the same population and pair‐wise matched with respect to sex, age, education, and estimated intelligence. Results For the exposed group, mean PCP serum level was 43.6μg/l and mean γ‐HCH blood level was 0.085μg/l. Mean duration of exposure was 10 (5–17) years. Intellectual functioning, attention, memory, and visuo‐motor performance were examined, suggesting significant group differences in visual short‐term memory (Benton Test; d > 1.5, P > .005), verbal memory (paired associate learning and Peterson paradigm; d > 4.3 and 1.6, P < .001), and an incidental learning task (d > 2.3; P > .001). Frequent subjective complaints as assessed by questionnaire were attenuated motivation (d > 1.7; P > .001), increased fatigue (d > 1.6; P > .001), distractibility (d > 1.0; P > .003), and depressed mood (d > 1.9; P > .004). PCP blood level was significantly associated with paired‐associate learning, Benton Test, and reading/naming speed. Conclusions Long‐term low‐dose exposure to WPC in the domestic environment could be related to subjective complaints (attention, mood, and motivation) and to subtle alterations of neurobehavioral performance (e.g., working memory) in women. Am. J. Ind. Med. 35:632–641, 1999. © 1999 Wiley‐Liss, Inc.

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Clinical findings in workers exposed to pentachlorophenol

Cited by 63 publications

References 13 publications

The role of environmental estrogens and autoimmunity

The role of environmental estrogens and autoimmunity

Suppression of mouse complement activity by contaminants of technical grade pentachlorophenol

Long-term exposure to wood-preserving chemicals containing pentachlorophenol and lindane is related to neurobehavioral performance in women

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