2021
DOI: 10.1155/2021/6653969
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Association between Red Blood Cell Distribution Width and Diabetic Retinopathy: A 5-Year Retrospective Case-Control Study

Abstract: Purpose. Red blood cell distribution width (RDW) has been regarded as an emerging biomarker of the general population and cardiovascular disease. In this study, we aimed to evaluate the association between RDW and diabetic retinopathy (DR). Methods. This case-control study included 167 patients with DR, 131 patients with diabetes mellitus (DM), and 170 age- and sex-matched healthy controls from April 2014 to May 2019. Demographic data, laboratory parameters, and ocular examinations were collected. Results. RDW… Show more

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Cited by 8 publications
(7 citation statements)
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“…Systemic inflammation not only affects the survival of red blood cells and platelets but also deforms their membranes [ 12 , 17 , 28 , 29 ]. RDW is a parameter that measures variations in red blood cell size.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Systemic inflammation not only affects the survival of red blood cells and platelets but also deforms their membranes [ 12 , 17 , 28 , 29 ]. RDW is a parameter that measures variations in red blood cell size.…”
Section: Discussionmentioning
confidence: 99%
“…Increased concentrations of various inflammatory cytokines in aqueous humor and serum, such as interleukin 6 (IL-6), interleukin 8 (IL-8), and vascular endothelial growth factor (VEGF), have been found in patients with RVO and have been shown to be related to the severity of the disease, which suggests that local and systemic inflammation is involved in the pathogenesis of RVO [7][8][9][10]. Recently, cell counts in peripheral blood samples and their combinations have been used to evaluate the inflammatory response status of ocular vascular diseases [11][12][13][14][15]. Several parameters, including the mean platelet volume (MPV), red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), have been shown to be related to the development of RVO [11,[15][16][17][18][19].…”
Section: Introductionmentioning
confidence: 99%
“… 53 Higher RDW predicts a higher risk of diabetic complications, such as diabetic ketoacidosis (DKA) or diabetic retinopathy. 54 , 55 This was due to the presence of micro- and macro-angiopathy with hyperglycemia that shortens the lifespan of RBCs. 52 The association between ΔRDW and diabetic complications should be further investigated.…”
Section: δRdw and Diabetes Mellitusmentioning
confidence: 99%
“…This suggests that there is poor blood and various hematopoietic abnormalities. It was evident that RDW was generally elevated in patients with diabetes and its complications 16,17 . Moreover, elevated RDW is associated with severe imbalance of RBC homeostasis, abnormal RBC production and survival.…”
Section: Introductionmentioning
confidence: 99%
“…It was evident that RDW was generally elevated in patients with diabetes and its complications. 16 , 17 Moreover, elevated RDW is associated with severe imbalance of RBC homeostasis, abnormal RBC production and survival. This may be associated with oxidative stress, vascular inflammation, and malnutrition such as iron, vitamin B 12, and folic acid deficiencies.…”
Section: Introductionmentioning
confidence: 99%