ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases

Wang, Jingsheng; Xiao, Qiang; Li, Yuanmin

doi:10.2147/ijgm.s339945

Cited by 9 publications

(9 citation statements)

References 71 publications

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“…This study has some limitations. First, blood transfusion was not excluded, which may have had an important impact on the RDW state [30]. Second, although different dairy product feeding resulted in inconsistent risk of abdominal distension, feeding intolerance, and speed of milk addition, we were unable to distinguish between different dairy products due to small sample sizes.…”

Section: Discussionmentioning

confidence: 99%

Association between Red Blood Cell Distribution Width and the Speed of Adding Milk with Non- invasive Positive Pressure Ventilation Mode in Preterm Infants

Feng,

Hu,

et al. 2024

Preprint

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Background Non-invasive positive pressure ventilation (NIPPV) is applied in the early postnatal period in most preterm infants; however, whether it slows down milk addition speed remains debatable. Elevated red blood cell distribution width (RDW) causes gastrointestinal ischemia and enteral feeding risks. This study aimed to explore the relationship between RDW and the speed of adding milk in NIPPV mode (SAMNIPPV) in preterm infants during hospitalization. Methods Between 01/05/2022 and 30/11/2022, 110 preterm infants (gestational age < 32 weeks, birth weight < 1500 g) treated with NIPPV were included to calculate the speed of milk addition. RDW was extracted from the complete blood count results during hospitalization. Univariate and multivariate logistic regression analyses identified the association between RDW and SAMNIPPV. Results Low (15.1 ± 0.6%), mid (16.6 ± 0.4%), and high (19.0 ± 1.2%) RDW were observed in 37, 36, and 37 infants, respectively. The mean SAMNIPPV decreased with increasing RDW during hospitalization. Compared to the high SAMNIPPV group, the tripartite RDW levels in the low and mid SAMNIPPV groups differed significantly. Univariate analysis showed a reduction in the SAMNIPPV (2.1 mL/kg/d) when RDW was 16.9 ± 1.8%; both high and mid RDW were risk factors for low SAMNIPPV. In multivariate analysis, high RDW (19.0% ±1.2%) during hospitalization was a risk factor for low SAMNIPPV and determined as the predictive cut-off value for preterm infants with low SAMNIPPV. Conclusions An elevated RDW was associated with reduced speed of milk addition in preterm infants treated with NIPPV. Milk addition should be closely monitored when RDW is > 19.0 ± 1.2% during hospitalization as it significantly decreased the SAMNIPPV by 4.4 mL/kg/d.

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Section: Discussionmentioning

confidence: 99%

Association between Red Blood Cell Distribution Width and the Speed of Adding Milk with Non- invasive Positive Pressure Ventilation Mode in Preterm Infants

Feng,

Hu,

et al. 2024

Preprint

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“…We did not study the mechanism contributing to variability of RBC size. In humans, RDW variations are related to different types of anemias but there is also an association with age, gender, genetic factors, renal and liver function, blood pressure, metabolic factors and inflammation 1 . Many of these conditions are potent cardiovascular risk factors, therefore relation between RDW and atherosclerosis may be incidental not causal.…”

Section: Discussionmentioning

confidence: 99%

“…However, during last decade, numerous studies showed that high RDW strongly correlates with cardiovascular and all-cause morbidity and mortality in healthy populations as well as patients with various clinical conditions. This includes cardiovascular diseases (hypertension, carotid atherosclerosis, coronary heart disease, heart failure, atrial fibrillation, pulmonary embolism, ischemic stroke), cancer, diabetes, acute pancreatitis, liver and kidney failure, sepsis, Parkinsonism and COVID-19 1 , 2 . High RDW value has been reported to be a strong predictor of unfavorable clinical outcomes independent of concomitant conditions and could be used for risk stratification in certain groups of patients.…”

Section: Introductionmentioning

confidence: 99%

Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall

Ananthaseshan

Bojakowski

Sacharczuk

et al. 2022

Sci Rep

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The mechanism underlying the association between elevated red cell distribution width (RDW) and poor prognosis in variety of diseases is unknown although many researchers consider RDW a marker of inflammation. We hypothesized that RDW directly affects intravascular hemodynamics, interactions between circulating cells and vessel wall, inducing local changes predisposing to atherothrombosis. We applied different human and animal models to verify our hypothesis. Carotid plaques harvested from patients with high RDW had increased expression of genes and proteins associated with accelerated atherosclerosis as compared to subjects with low RDW. In microfluidic channels samples of blood from high RDW subjects showed flow pattern facilitating direct interaction with vessel wall. Flow pattern was also dependent on RDW value in mouse carotid arteries analyzed with Magnetic Resonance Imaging. In different mouse models of elevated RDW accelerated development of atherosclerotic lesions in aortas was observed. Therefore, comprehensive biological, fluid physics and optics studies showed that variation of red blood cells size measured by RDW results in increased interactions between vascular wall and circulating morphotic elements which contribute to vascular pathology.

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“…In addition, RDW was usually measured at a single time point (mainly at admission) in previous studies. There have been few relevant studies on the predictive value of changes in RDW for different diseases 15 . Thus, the effect of dynamic changes in RDW in patients with CRC remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of increased preoperative red cell distribution width (RDW) and changes in RDW for colorectal cancer

Huang

Xue

et al. 2023

Cancer Medicine

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ΔRDW: A Novel Indicator with Predictive Value for the Diagnosis and Treatment of Multiple Diseases

Cited by 9 publications

References 71 publications

Association between Red Blood Cell Distribution Width and the Speed of Adding Milk with Non- invasive Positive Pressure Ventilation Mode in Preterm Infants

Association between Red Blood Cell Distribution Width and the Speed of Adding Milk with Non- invasive Positive Pressure Ventilation Mode in Preterm Infants

Red blood cell distribution width is associated with increased interactions of blood cells with vascular wall

Prognostic significance of increased preoperative red cell distribution width (RDW) and changes in RDW for colorectal cancer

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