Association between red blood cell distribution width‐to‐albumin ratio and diabetic retinopathy

Fang, Zhao; Liu, MengYun; Kong, Lingzhen

doi:10.1002/jcla.24351

Cited by 17 publications

(15 citation statements)

References 36 publications

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“…Experimental evidence has shown that albumin has antioxidant activity, and plays a protective role by thinning the blood and reducing oxidative stress ( 35 – 37 ). Several studies have shown that serum albumin level is associated with the outcomes of various diseases including cardio-cerebrovascular diseases, mainly due to malnutrition and inflammation ( 15 , 33 , 38 – 40 ). Moreover, low serum albumin concentration has been reported to be associated with adverse clinical outcomes of ischemic heart disease ( 41 – 44 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a low serum albumin level is strongly negatively correlated with the risk of death from cardiovascular diseases ( 12 ). Recent studies have shown that the ratio of RDW to albumin (RA) is associated with the prognosis of a variety of diseases, including aortic aneurysm, diabetic retinopathy, and shock ( 13 – 15 ). However, it is unknown whether combining RDW with albumin can more effectively predict the prognosis of patients after PCI.…”

Section: Introductionmentioning

confidence: 99%

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The Ratio of Red Blood Cell Distribution Width to Albumin Is Correlated With All-Cause Mortality of Patients After Percutaneous Coronary Intervention – A Retrospective Cohort Study

Weng

Peng

et al. 2022

Front. Cardiovasc. Med.

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ObjectivesThe purpose of this study was to investigate the independent effect of the ratio of red blood cell distribution width (RDW) to albumin (RA) on all-cause mortality in patients after percutaneous coronary intervention (PCI).MethodsClinical data were obtained from the Multiparameter Intelligent Monitoring in Intensive Care-III (MIMIC-III) database version 1.4 and the database of Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University. We used the MIMIC-III database for model training, and data collected from the Second Affiliated Hospital of Wenzhou Medical University for validation. The primary outcome of our study was 90-day mortality. Cox proportional hazards regression model was used to estimate hazard ratio (HR) for the association between RA and all-cause mortality in patients after PCI. Pearson correlation analysis was conducted to assess the relationship between RA and Gensini score or cardiac troponin I (cTnI).ResultsA total of 707 patients were eligible in MIMIC-III database, including 432 males, with a mean age of 70.29 years. For 90-day all-cause mortality, in the adjusted multivariable model, the adjusted HRs [95% confidence intervals (CIs)] for the second (RA: 3.7–4.5 ml/g) and third (RA >4.5 ml/g) tertiles were 2.27 (1.11, 4.64) and 3.67 (1.82, 7.40), respectively, compared to the reference group (RA <3.7 ml/g) (p < 0.05). A similar relationship was also observed for 30-day all-cause mortality and 1-year all-cause mortality. No significant interaction was observed in subgroup analysis. Receiver operating characteristic (ROC) curve analysis proved that the ability of RA to predict the 90-day mortality was better than that of RDW or albumin alone. The correlation coefficient between Gensini score and RA was 0.254, and that between cTnI and RA was 0.323.ConclusionRA is an independent risk factor for all-cause mortality in patients after PCI. The higher the RA, the higher the mortality. RA has a good predictive ability for all-cause mortality in patients after PCI, which is better than RDW or albumin alone. RA may be positively correlated with the severity of coronary artery disease (CAD) in patients with CAD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Ratio of Red Blood Cell Distribution Width to Albumin Is Correlated With All-Cause Mortality of Patients After Percutaneous Coronary Intervention – A Retrospective Cohort Study

Weng

Peng

et al. 2022

Front. Cardiovasc. Med.

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“…RDW to albumin ratio (RAR) is a novel and simple biomarker of inflammation. Previous studies have demonstrated that RAR is associated with the prognosis of diabetic ketoacidosis (20), diabetic retinopathy (21), and cancer (22). Previous studies have demonstrated the effectiveness of RAR in predicting the prognosis of diseases such as diabetic ketoacidosis, diabetic retinopathy, and cancer.…”

Section: Introductionmentioning

confidence: 99%

Association between red blood cell distribution width to albumin ratio and prognosis of patients with sepsis: A retrospective cohort study

Huo

Chen

et al. 2022

Front. Nutr.

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BackgroundRed blood cell distribution width (RDW) to albumin ratio (RAR) is associated with poor prognosis in diabetic comorbidities and cancer. However, the association between RAR and prognosis in patients with sepsis remains unclear, which was investigated in this study.MethodsWe conducted a retrospective cohort study based on the Medical Information Mart for Intensive Care (MIMIC) IV version 2.0 database. The primary outcome of this study was 28-day mortality. Secondary outcomes included 90-day mortality, in-hospital mortality, length of hospital stay, and length of intensive care unit (ICU) stay. Multivariate regression analysis and subgroup analysis were performed to investigate the association between RAR and prognosis in patients with sepsis.ResultsA total of 14,639 participants were included in this study. The mean age of the participants was 65.2 ± 16.3 years and the mean RAR was 5.5 ± 1.9 % /g/dl. For 28-day mortality, after adjusting for covariates, HRs [95% confidence intervals (CIs)] for tertiles 2 (4.4–5.8) and 3 (RAR > 5.8) were 1.33 (1.20, 1.46) and 1.98 (1.79, 2.19), respectively. Similar results were observed for 90-day mortality and in-hospital mortality. According to Kaplan-Meier curve analysis, the higher RAR group had higher 28-day mortality and 90-day mortality.ConclusionOur study shows that RAR is significantly associated with poor clinical prognosis in sepsis. The higher the RAR, the higher the 28-day, 90-day, and in-hospital mortality.

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“… 4 In addition, albumin has been shown to be an inflammation marker. 13 , 30 In the studies of Chen and Takegawa et al, the albumin levels were emphasized to be a prognostic factor in patients with pneumonia or sepsis. 16 , 31 In many recent studies, low albumin levels on admission were proposed to be associated with all the other negative outcomes in addition to mortality in patients with severe COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…33 Therefore, RAR alone can reflect inflammatory states more accurately than either marker. 13,15,30 In the study of Yoo et al, conducted with patients with ARDS, the RAR levels were associated with 60-day mortality (hazard ratio 1.134, p = 0.003). The authors also reported that the calculated AUC value for RAR was higher than that for RDW alone (0.681, 0.576, respectively, p= 0.002).…”

mentioning

confidence: 99%

The Relationship Between Prognosis and Red Cell Distribution Width (RDW) and RDW-Albumin Ratio (RAR) in Patients with Severe COVID-19 Disease

Ertekin¹,

Acar²

2022

IJGM

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Purpose The present study aimed to investigate the relationship between prognosis and the red cell distribution width (RDW) and the RDW-albumin ratio (RAR) in patients with coronavirus diseases 2019 (COVID-19), since serum albumin and RDW levels may reflect inflammatory conditions. Patients and Methods A total of 289 patients who had been diagnosed with severe COVID-19 in the emergency department were retrospectively analyzed. The RAR levels were calculated by dividing RDW-CV by albumin. Patient groups (survivors, dying patients, those who received mechanical ventilation (MV) support or not, and those who needed vasopressors or not) were compared with regard to RDW-SD, RDW-CV and the RAR levels. Results RDW-SD, RDW-CV and the RAR levels were found to be statistically significantly higher in patients who died, and who received MV and vasopressor support, compared to those who survived and did not receive support (p<0.001 for all). In addition, while the cut-off value of RAR was >5.43, the sensitivity was 91.6%, the specificity was 93.7%, NPV was 93.1% and the AUC was 0.965 in predicting mortality (p<0.001). Logistic regression analysis showed that RDW-SD and RAR were independent risk factors for mortality in patients with severe COVID-19. Conclusion Elevated RDW and RAR levels at the time of admission may independently predict mortality and the need for vasopressor or MV support.

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Association between red blood cell distribution width‐to‐albumin ratio and diabetic retinopathy

Cited by 17 publications

References 36 publications

The Ratio of Red Blood Cell Distribution Width to Albumin Is Correlated With All-Cause Mortality of Patients After Percutaneous Coronary Intervention – A Retrospective Cohort Study

The Ratio of Red Blood Cell Distribution Width to Albumin Is Correlated With All-Cause Mortality of Patients After Percutaneous Coronary Intervention – A Retrospective Cohort Study

Association between red blood cell distribution width to albumin ratio and prognosis of patients with sepsis: A retrospective cohort study

The Relationship Between Prognosis and Red Cell Distribution Width (RDW) and RDW-Albumin Ratio (RAR) in Patients with Severe COVID-19 Disease

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