Characteristics of Hematologic Parameters in Young Patients with Retinal Vein Occlusion

Abstract

<b><i>Introduction:</i></b> The aim of this study was to investigate the characteristics of hematologic parameters in young patients with retinal vein occlusion (RVO). <b><i>Methods:</i></b> All participants underwent routine ocular examinations and blood sample tests. Hematologic parameters obtained from a complete blood count, as well as the calculation of specific inflammatory indices, were compared between young patients with RVO and the control subjects. Correlations between hematologic inflammatory biomarkers and aqueous humor inflammatory cytokines were also investigated. <b><i>Results:</i></b> A total of 64 patients with RVO and 64 age- and gender-matched control subjects were included in this study. The white blood cell count, neutrophil cell count, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) in young patients with RVO were significantly higher than in the controls (all <i>p</i> < 0.05). Compared to patients with nonischemic RVO, patients with ischemic RVO had higher NLR, SII, and SIRI values (<i>p</i> = 0.032, <i>p</i> = 0.035, and <i>p</i> = 0.039, respectively). The areas under the receiver operator characteristic curve were 0.725, 0.651, 0.649, and 0.634 for the MPV, NLR, SII, and SIRI, respectively. In addition, a higher NLR was related to higher levels of interleukin 6 (IL-6; <i>p</i> = 0.046, <i>R</i> = 0.463), and a higher SII was related to higher levels of IL-6 (<i>p</i> = 0.034, <i>R</i> = 0.488) and vascular endothelial growth factor (<i>p</i> = 0.020, <i>R</i> = 0.528). <b><i>Conclusion:</i></b> The NLR, SII, and SIRI were significantly elevated in young patients with RVO, especially in young patients with ischemic RVO. NLR and SII were positively correlated with IL-6 levels in aqueous humor, which indicated that systemic inflammation plays an important role in the onset of RVO in young patients.

Assessment of systemic inflammatory response index and other inflammatory indicators in retinal vein occlusion

“…[21] NLR, one of the most studied inflammatory markers due to the close relationship between RVO and atherosclerosis, is high in patients with RVO in many studies, suggesting that it could be used as a predictive marker in identifying the risk of RVO. [8][9][10] Kazantzis et al [9] reported that NLR was superior to other inflammatory indicators in predicting the inflammatory status of RVO. In the current study, NLR has the highest AUC (0.817) according to ROC analysis.…”

“…[ 9 ] In another study, elevated SII was found to be correlated with high levels of IL-6 and VEGF in patients with RVO. [ 8 ] Zuo et al [ 10 ] found that the AUC of SII (0.666) was highest in patients with RVO. In their study, the optimal cutoff value of SII to predict RVO was > 326.46, with a sensitivity of 66.1% and specificity of 58.9%.…”

“…In many pathologies based on inflammation, inflammatory indicators obtained from peripheral blood are now used as prognostic markers and progression predictors of many diseases, including RVO. [7–15]…”

“…In many pathologies based on inflammation, inflammatory indicators obtained from peripheral blood are now used as prognostic markers and progression predictors of many diseases, including RVO. [7][8][9][10][11][12][13][14][15] This is the first study to evaluate systemic inflammation response index (SIRI) and monocyte-to-lymphocyte ratio (MLR) in elderly patients with RVO. The present study aims to determine the potential associations and the predictive value of inflammatory indicators such as the SIRI, neutrophil-tolymphocyte ratio (NLR), MLR, platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and other hematologic parameter characteristics in patients with RVO.…”