Association between interleukin-1β-511C/T polymorphism and reflux esophagitis in Japan

Muramatsu, Akinori; Azuma, Takeshi; Okuda, Tomoyuki; Satomi, Satoko; Ohtani, Masahiro; Lee, Soshoku; Suto, Hiroyuki; Ito, Yoshiyuki; Yamazaki, Yukinao; Kuriyama, Masaru

doi:10.1007/s00535-005-1672-2

Cited by 22 publications

(28 citation statements)

References 33 publications

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“…However, iceA1 is much dominant compared to iceA2 in our country, and is consistent with Holland (35), Japan (36) and Hong Kong (37) fi ndings. Studies conducted in USA (38), Columbia (39) and Brazil showed that iceA2 was dominant (40). Peek et al (41) and van Doorn et al (35) reported meaningful association between iceA1 genotype and peptic ulcer, and no statistically signifi cant difference was found in our study between the two groups with refl ux esophagitis and peptic ulcer in terms of iceA1 and iceA2 (IceA1 p=0,556, IceA2 p=0,747).…”

Section: Discussioncontrasting

confidence: 44%

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A pilot study of Helicobacter pylori genotypes and cytokine gene polymorphisms in reflux oesophagitis and peptic ulcer disease

Akdoğan¹,

Özgür²,

Gucuyeter³

et al. 2014

BLL

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Abstract:Helicobacter pylori causes various diseases such as chronic gastritis, peptic ulcer and gastric cancer. While majority of the people infected with H. pylori is asymptomatic, 15-20 % of them develop such diseases. The main factors, which determine the development of H. pylori related diseases might be bacterial virulence, host genetic and environmental factors. The aim of this study was to reveal the factors that play a role in the disease development in patients with refl ux esophagitis and peptic ulcer, infected with Helicobacter pylori. Environmental factors such as medical agents, smoking and body mass index were evaluated. The factors specifi c to bacteria such as vacA, CagA, babA and iceA virulence genotypes and the host factors such as IL-1, IL-2, IL-4, IL-6, IL-10, IL-12, interferon-γ, TNF-α, ve TGF-β 1 gene polymorphisms were compared between the two groups. H. pylori infected twenty fi ve patients with refl ux esophagitis and peptic ulcer were enrolled in the study. There was no statistical difference between the two groups regarding environmental factors. IL-2 -330T +166T (p=0.037) and IL10 -1082A; -819C (p=0.049) gene polymorphisms were signifi cantly more common in the group of patients with peptic ulcer compared to the group with refl ux esophagitis. In both groups of patients, either with refl ux esophagitis or peptic ulcer, multiple H. pylori virulence genotypes (cagA, vacA, babA) (mean values 74 %, 78 %, 54 % respectively) were observed. In this study, we revealed that cytokine gene polymorphisms may play a role in the development peptic ulcer while H. pylori virulence genotypes seem to be crucial for the development of associated diseases (Tab. 4, Ref. 51). Text in PDF www.elis.sk.

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Section: Discussioncontrasting

confidence: 44%

“…There is a limited number of studies relating to gastroesophageal refl ux disease and cytokine gene polymorphism. Muramatsu et al reported increased IL-1β-511C/T polymorphism in patients with refl ux esophagitis (40).…”

Section: Discussionmentioning

confidence: 99%

A pilot study of Helicobacter pylori genotypes and cytokine gene polymorphisms in reflux oesophagitis and peptic ulcer disease

Akdoğan¹,

Özgür²,

Gucuyeter³

et al. 2014

BLL

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“…The results of the study carried out in Japan were very different from the previous published ones. It is concluded that the levels of IL-1β (-511) C were correlated to the higher gastric mucosal IL-1β levels (11). The contradictory results guided the presence of ethnic differences of IL-1gene polymorphisms in patients with GERD.…”

Section: Introductionmentioning

confidence: 98%

The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease

Akcil

Doğan²,

Cengiz³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Our aim is to assess the relationship between interleukin 1β (IL-1 β), (-511,-31 alleles), interleukin 1RN (IL-RN), Helicobacter pylori (HP) status and gastroesophageal reflux disease (GERD) diagnosed by pH monitoring in the Turkish population. Materials and Methods: A Total of 100 consecutive patients with GERD were enrolled in the study. Genotypes of IL-1β (-511,-31), IL-1RN gene polymorphisms and HP status of the patients were analyzed. Results: While thirty-two patients were diagnosed as esophagitis with varying severity the remaining patients had no esophagitis. Seventy six participants were positive for HP and the remaining patients were negative. The difference between erosive and non-erosive groups was statistically significant when we compared IL-1β (-511) but no difference regarding IL-1β (-31) and IL-1RN variations. We also analyzed T/T, C/T and C/C alleles and the difference was significant statistically in T/T allele between patients with and without erosive GERD 1 (3.1%) vs. 12 (17.9%), respectively with a p value <0.05. But C/C, C/T alleles of (-511), (-31) and IL-1RN polymorphisms were not statistically significant between the groups. Conclusion: IL-1β genetic polymorphisms may take part in the pathophysiology of gastroesophageal reflux disease.

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“…A prospective study by Queiroz et al [25] indicated that T allele at IL-1B-511 was a protective factor against GERD. However, Muramatsu et al [24] found that the frequency of IL-1B-511 T alleles was significantly higher in GERD. In addition, Lzakovicova et al [23] claimed T allele of IL-1B-511 was not associated with GERD.…”

Section: Discussionmentioning

confidence: 97%

Association of interleukin-1B gene polymorphisms at site 511 with gastroesophageal reflux disease: a meta-analysis

Xue

Zhang

et al. 2015

Esophagus

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Association between interleukin-1β-511C/T polymorphism and reflux esophagitis in Japan

Abstract: IL-1beta-511T was associated with reflux esophagitis having hyperacidity. Differences of genetic background regarding gastric acid secretion may exist between Japanese and Caucasians.

Cited by 22 publications

References 33 publications

A pilot study of Helicobacter pylori genotypes and cytokine gene polymorphisms in reflux oesophagitis and peptic ulcer disease

A pilot study of Helicobacter pylori genotypes and cytokine gene polymorphisms in reflux oesophagitis and peptic ulcer disease

The role of interleukin-1 gene polymorphisms and Helicobacter pylori in gastroesophageal reflux disease

Association of interleukin-1B gene polymorphisms at site 511 with gastroesophageal reflux disease: a meta-analysis

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