Association of interleukin-1B gene polymorphisms at site 511 with gastroesophageal reflux disease: a meta-analysis

Xue, Meng; Zhang, Sujuan; Li, Jia; Li, Wei; Wang, Dongxu

doi:10.1007/s10388-015-0498-0

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…В чешском исследовании, проведенном на 333 пациентах с ГЭРБ (165 человек -контроль), установлено, что гаплотипы ИЛ-1 могут быть ассоциированы с рефлюкс-эзофагитом и пищеводом Барретта [24]. Однако в метаанализе, направленном на выявление связи между полиморфизмом ИЛ-1β-511(С/Т) и риском ГЭРБ, основанном на восьми исследованиях со 1119 пациентами с гастроэзофагеальным рефлюксом, не выявлено определенных ассоциаций между изученными аллелями и генотипами и предрасположенностью к ГЭРБ [25]. В то же время в работах, посвященных изучению цитокинового профиля у лиц с пищеводом Барретта и аденокарциномой, была показана роль Т-хелперов в инициации эзофагита.…”

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The role of interleukin 1β and interleukin 1 receptor antagonist polymorphism genes, Helicobacter pylori infection and the state of the gastric mucosa in the development and progression of gastroesophageal reflux disease

Александровна

Lareva

Luzina

2020

Tihookeanskij medicinskij žurnal

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The mechanisms of the gastroesophageal reflux disease (GERD) development and its complications are analyzed on the tissue and cell levels. That’s why studying polymorphism of interleukin (IL) genes is important. Genotypes IL1β-511Т/Т, IL1β31С/С and IL1RN2/2 (receptor antagonist IL1) associate with high risk of complicated course of GERD disease. Researching genes polymorphism of the pro-inflammatory cytokines of the patients having gastroesophageal reflux disease and changes in gastric mucosa it was determined that genotype IL1β-511Т/Т is associated with the deeper local level of IL1β. Meanwhile the patients having erosive esophagitis had lover level of IL1β. It was determined that genotype IL1RN2/2 and haplotype IL1RN*2 /IL1В-31*Т are connected with the high risk of esophagus cancer of patients having Helicobacter pylori. Genotype IL1β-511Т/Т and haplotype IL1β-511Т/Т /IL1RN1/1 of the patients having GERD are associated with the low risk of the esophagus cancer. So, the allele IL1RN*2 and genotype IL1RN2/2 can combine by independent predictors of GERD progression. The study of this field should be continued taking into account not only changes in gastric mucosa, presence of helicobacteriosis, but also the nature of gastroesophageal reflux.

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