Association Between Estrogen Receptor Gene Polymorphism and Back Pain Intensity in Female Patients With Degenerative Lumbar Spondylolisthesis

Roh, Hyoung Lok; Lee, Jung Sub; Suh, Kuen Tak; Kim, Jeung Il; Lee, Hong Seok; Goh, Tae Sik; Park, Shi Hwan

doi:10.1097/bsd.0b013e318260a09c

Cited by 10 publications

(3 citation statements)

References 42 publications

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“…With the anatomical studies of the location of ERs in mind, one may speculate that ERs are involved not only in ER-dependent cancers but also in cardiovascular disease, osteoporosis, neurological disorders and disorders of the immune system (Nilsson et al, 2004). Mutations, deletions and polymorphisms have been reported in the ER genes and they have also, to some extent, been related to different disorders including certain pain conditions (Kang et al, 2007;Nilsson et al, 2004;Ribeiro-Dasilva et al, 2009;Roh et al, 2012;Ushiyama et al, 1998). Since the naturally occurring ligands of the ER are agonists, the actions of co-repressors are also important in the prevention of a chronically high expression of ER-inducible genes.…”

Section: Are the Effects Of Estrogens On Pain Transmission Of Any Sigmentioning

confidence: 99%

Estrogenic influences in pain processing

Amandusson

Blomqvist

2013

Frontiers in Neuroendocrinology

104

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Gonadal hormones not only play a pivotal role in reproductive behavior and sexual differentiation, they also contribute to thermoregulation, feeding, memory, neuronal survival, and the perception of somatosensory stimuli. Numerous studies on both animals and human subjects have also demonstrated the potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and they therefore need to be evaluated specifically to determine the localization and intrinsic characteristics of the neurons engaged. The aim of this review is to summarize the morphological as well as biochemical evidence in support for gonadal hormone modulation of nociceptive processing, with particular focus on estrogens and spinal cord mechanisms.

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Section: Are the Effects Of Estrogens On Pain Transmission Of Any Sigmentioning

confidence: 99%

Estrogenic influences in pain processing

Amandusson

Blomqvist

2013

Frontiers in Neuroendocrinology

104

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show abstract

“…Roh et al also focused on estrogen receptors in patients with degenerative spondylolisthesis. In their study, the authors demonstrated a relationship between a polymorphism of this type of receptor and the severity of slip-related symptoms [ 126 ]. A similar relationship was evident in an earlier work by Lee et al [ 127 ].…”

Section: Risk Factorsmentioning

confidence: 99%

Factors Predisposing to The Formation of Degenerative Spondylolisthesis—A Narrative Review

et al. 2023

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The relationship between various factors predisposing to the formation of spondylolisthesis, including degenerative spondylolisthesis, has been analyzed by many authors. However, not all observations are consistent. In this review, we identified factors whose impact on the prevalence of spondylolisthesis was most often mentioned in the literature. These included gender, age, bone mineral density, ethnic origin, and oophorectomy. The results were inclusive in terms of physical activity, pregnancy status, and use of hormone replacement therapy. Associations between diabetes and smoking were very poorly marked. The literature so far has identified a number of factors significantly affecting the incidence of degenerative spondylolisthesis. These include age, gender, body weight, ethnic origin, bone mineral density, and hormonal balance. Radiological parameters, which include iliac crest, pelvic tilt, pelvic incidence, sacral slope, and lumbar lordosis, may also be of great importance for assessing changes in the occurrence and progression. However, the authors do not agree on the real significance of individual factors. The aim of this review was to identify the factors predisposing to the formation of degenerative spondylolisthesis, the importance of which has been suggested in the current literature. The systematization of knowledge in this field can allow a more accurate adjustment of the treatment plan for each patient affected by this condition.

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“…Roh et al [29] examined the relationship between estrogen receptor (ER) alpha (α) (ERα) polymorphisms and degenerative spondylolisthesis (DS) patients. A strong association was found between Xbal polymorphism and the VAS score of back pain.…”

Section: Esr (Estrogen Receptor 1)mentioning

confidence: 99%

Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain?

et al. 2020

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Etiology of back pain is multifactorial and not completely understood, and for the majority of people who suffer from chronic low back pain (cLBP), the precise cause cannot be determined. We know that back pain is somewhat heritable, chronic pain more so than acute. The aim of this review is to compile the genes identified by numerous genetic association studies of chronic pain conditions, focusing on cLBP specifically. Higher-order neurologic processes involved in pain maintenance and generation may explain genetic contributions and functional predisposition to formation of cLBP that does not involve spine pathology. Several genes have been identified in genetic association studies of cLBP and roughly, these genes could be grouped into several categories, coding for: receptors, enzymes, cytokines and related molecules, and transcription factors. Treatment of cLBP should be multimodal. In this review, we discuss how an individual’s genotype could affect their response to therapy, as well as how genetic polymorphisms in CYP450 and other enzymes are crucial for affecting the metabolic profile of drugs used for the treatment of cLBP. Implementation of gene-focused pharmacotherapy has the potential to deliver select, more efficacious drugs and avoid unnecessary, polypharmacy-related adverse events in many painful conditions, including cLBP.

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Association Between Estrogen Receptor Gene Polymorphism and Back Pain Intensity in Female Patients With Degenerative Lumbar Spondylolisthesis

Abstract: These results suggest that the ERα gene polymorphism using XbaI restriction enzyme influences the perception of back pain in patients with DS.

Cited by 10 publications

References 42 publications

Estrogenic influences in pain processing

Estrogenic influences in pain processing

Factors Predisposing to The Formation of Degenerative Spondylolisthesis—A Narrative Review

Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain?

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