Estrogenic influences in pain processing

Amandusson, Åsa; Blomqvist, Anders

doi:10.1016/j.yfrne.2013.06.001

Cited by 109 publications

(87 citation statements)

References 326 publications

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“…The earliest studies examining ER distribution in the brain employed autoradiographic techniques (Pfaff, 1968), and immunohistochemistry and in situ hybridization experiments have confirmed and extended these findings (Amandusson and Blomqvist, 2013). An observation which has received little recent attention or discussion is of particular relevance to the current review: almost all of the sites that receive direct input from the SCN express AR, ER or some combination of both (Figure 5B).…”

Section: Sex Differences In the Circadian Timing Systemmentioning

confidence: 98%

Sex differences in circadian timing systems: Implications for disease

Bailey

Silver

2014

Frontiers in Neuroendocrinology

269

196

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Virtually every eukaryotic cell has an endogenous circadian clock and a biological sex. These cell-based clocks have been conceptualized as oscillators whose phase can be reset by internal signals such as hormones, and external cues such as light. The present review highlights the inter-relationship between circadian clocks and sex differences. In mammals, the suprachiasmatic nucleus (SCN) serves as a master clock synchronizing the phase of clocks throughout the body. Gonadal steroid receptors are expressed in almost every site that receives direct SCN input. Here we review sex differences in the circadian timing system in the hypothalamic-pituitary-gonadal axis (HPG), the hypothalamicadrenal-pituitary (HPA) axis, and sleep-arousal systems. We also point to ways in which disruption of circadian rhythms within these systems differs in the sexes and is associated with dysfunction and disease. Understanding sex differentiated circadian timing systems can lead to improved treatment strategies for these conditions.

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Section: Sex Differences In the Circadian Timing Systemmentioning

confidence: 98%

Sex differences in circadian timing systems: Implications for disease

Bailey

Silver

2014

Frontiers in Neuroendocrinology

269

196

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“…Estrogen’s effect on the brain can occur via at least three distinct pathways: direct diffusion of peripheral estrogen into the CNS, conversion of testosterone and androstenedione in the brain by aromatases in the presynaptic terminals in the brain [11] or de-novo synthesis of estrogen in the brain from cholesterol [12]. In the brain, estrogen can exert its effect by binding to estrogen receptors, usually located in the nucleus or cytoplasm, with subsequent gene transcription and protein synthesis; or alternatively estrogen can act by nongenomic mechanisms [13]. Recent data suggest that the transcriptional activity of human brain estrogen receptors is cell-type specific [14].…”

Section: Estrogen and The Central Nervous Systemmentioning

confidence: 99%

“…As estrogen can extend its impact in a variety of systems, its role in headache is likely multifactorial, including direct cellular and genetic modifications in the CNS, as well as potentially as a result of its effect on mood and pain perception [13,38,39]. Furthermore, the relationship between various sex hormones (i.e.…”

Section: Therapeutic Considerations and Future Directionsmentioning

confidence: 99%

Migraine and estrogen

Chai

Peterlin

Calhoun

2014

Current Opinion in Neurology

117

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Purpose of review The aim is to systematically and critically review the relationship between migraine and estrogen, the predominant female sex hormone, with a focus on studies published in the last 18 months. Recent findings Recent functional MRI (fMRI) studies of the brain support the existence of anatomical and functional differences between men and women, as well as between participants with migraine and healthy controls. In addition to the naturally occurring changes in endogenous sex hormones over the lifespan (e.g. puberty and menopause), exogenous sex hormones (e.g. hormonal contraception or hormone therapy) also may modulate migraine. Recent data support the historical view of an elevated risk of migraine with significant drops in estrogen levels. In addition, several lines of research support that reducing the magnitude of decline in estrogen concentrations prevents menstrually related migraine (MRM) and migraine aura frequency. Summary Current literature has consistently demonstrated that headache, in particular migraine, is more prevalent in women as compared with men, specifically during reproductive years. Recent studies have found differences in headache characteristics, central nervous system anatomy, as well as functional activation by fMRI between the sexes in migraine patients. Although the cause underlying these differences is likely multifactorial, considerable evidence supports an important role for sex hormones. Recent studies continue to support that MRM is precipitated by drops in estrogen concentrations, and minimizing this decline may prevent these headaches. Limited data also suggest that specific regimens of combined hormone contraceptive use in MRM and migraine with aura may decrease both headache frequency and aura.

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“…Women also seem to report more severe acute postoperative pain in general,46 which might be related to estrogen modulation of nociceptive processing 47. Although obesity has sometimes been denominated a risk factor, no firm conclusions can be made 9…”

Section: Risk Factorsmentioning

confidence: 99%

Pain control following inguinal herniorrhaphy: current perspectives

Bjurström¹,

Nicol²,

Amid³

et al. 2014

JPR

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Inguinal hernia repair is one of the most common surgeries performed worldwide. With the success of modern hernia repair techniques, recurrence rates have significantly declined, with a lower incidence than the development of chronic postherniorrhaphy inguinal pain (CPIP). The avoidance of CPIP is arguably the most important clinical outcome and has the greatest impact on patient satisfaction, health care utilization, societal cost, and quality of life. The etiology of CPIP is multifactorial, with overlapping neuropathic and nociceptive components contributing to this complex syndrome. Treatment is often challenging, and no definitive treatment algorithm exists. Multidisciplinary management of this complex problem improves outcomes, as treatment must be individualized. Current medical, pharmacologic, interventional, and surgical management strategies are reviewed.

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Estrogenic influences in pain processing

Cited by 109 publications

References 326 publications

Sex differences in circadian timing systems: Implications for disease

Sex differences in circadian timing systems: Implications for disease

Migraine and estrogen

Pain control following inguinal herniorrhaphy: current perspectives

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