Association between circulating levels of galanin and pre-pregnancy body mass index in patients with gestational diabetes mellitus

Zhang, Zhenwen; Fang, Penghua; Shi, Mingyi; Gu, Chunmei; Wang, Yan; Bo, Ping; Zhu, Yichao

doi:10.1016/j.eatbeh.2015.06.003

Cited by 11 publications

(12 citation statements)

References 24 publications

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“…demonstrated that plasma GAL levels were significantly higher in patients with gestational diabetes, compared to plasma GAL levels of pregnant women with normal glucose tolerance15. Additionally, these authors reported that plasma GAL levels are positively correlated with BMI and fasting plasma glucose in the group of women who developed gestational diabetes15. On the other hand, and contrary to our results, Legakis et al .…”

Section: Discussioncontrasting

confidence: 99%

“…Zhang et al . showed a significant positive correlation between GAL and HOMA-IR, but no correlation with serum insulin levels15. Fang et al .…”

Section: Discussionmentioning

confidence: 97%

“…Also, plasma GAL levels were elevated in obese young women in comparison with normally menstruating women13. Additionally, recent studies show significantly high serum GAL levels in pregnant women with gestational diabetes141516, but no differences in GAL levels were detected in neonates born to gestational diabetic mothers, neonates with intrauterine growth restriction and healthy neonates17. GAL levels were also increased in type 1 and type 2 diabetes314161819, positively correlated with the blood glucose level320, and with hemoglobin A1c content among type 1 diabetes mellitus patients18.…”

mentioning

confidence: 97%

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Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Sandoval-Alzate

Agudelo-Zapata

Clavijo

et al. 2016

Sci Rep

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Galanin (GAL) is a neuropeptide involved in the homeostasis of energy metabolism. The objective of this study was to investigate the serum levels of GAL during an oral glucose tolerance test (OGTT) in lean and obese young men. This cross-sectional study included 30 obese non-diabetic young men (median 22 years; mean BMI 37 kg/m2) and 30 healthy lean men (median 23 years; mean BMI 22 kg/m2). Serum GAL was determined during OGTT. The results of this study include that serum GAL levels showed a reduction during OGTT compared with basal levels in the lean subjects group. Conversely, serum GAL levels increased significantly during OGTT in obese subjects. Serum GAL levels were also higher in obese non-diabetic men compared with lean subjects during fasting and in every period of the OGTT (p < 0.001). Serum GAL levels were positively correlated with BMI, total fat, visceral fat, HOMA–IR, total cholesterol, triglycerides and Leptin. A multiple regression analysis revealed that serum insulin levels at 30, 60 and 120 minutes during the OGTT is the most predictive variable for serum GAL levels (p < 0.001). In conclusion, serum GAL levels are significantly higher in the obese group compared with lean subjects during an OGTT.

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Section: Discussioncontrasting

confidence: 99%

“…Zhang et al . showed a significant positive correlation between GAL and HOMA-IR, but no correlation with serum insulin levels15. Fang et al .…”

Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 97%

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Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Sandoval-Alzate

Agudelo-Zapata

Clavijo

et al. 2016

Sci Rep

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“…Moreover, a positive association was shown between the plasma concentrations of galanin and HbA1c in children with T1DM 23. Zhang et al24 showed a significant positive correlation between galanin and HO MA-I R. These data seem to indicate that the enhanced galanin concentration may be a consequence of increased serum glucose. Regarding the lipid profile, Fang et al25 reported that a statistically significant positive correlation between galanin concentrations and TG in obese participants.…”

Section: Discussionmentioning

confidence: 92%

Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome

Alotibi

Alnoury

Alhozali

2019

SMJ

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Objectives: To investigate the serum levels of nesfatin-1 and galanin in patients with metabolic syndrome (MetS), and also to show their association with the parameters of the disease. Methods: We performed a case-control study with 84 participants (44 patients with MetS diagnosed according to the American Heart Association/National Heart, Lung, and Blood Institute and International Diabetes Federation criteria and 40 control group) were recruited from King Abdulaziz University Hospital, Jeddah, Saudi Arabia, between October 2014 and June 2015. Anthropometric parameters, biochemical markers as well as nesfatin-1 and galanin were measured. Results: Nesfatin-1 levels were found to be significantly lower and galanin levels significantly higher in MetS group compared to the control group. A significant negative correlation between serum nesfatin-1 and weight, waist circumference, and body mass index were observed. A significant positive correlation between serum galanin and with fasting blood glucose, glycosylated hemoglobin, homeostasis model assessment-insulin resistance, and triglycerides. Conclusion: Our findings indicated a lower level of nesfatin-1 and a higher level of galanin in patients with MetS, suggesting a role of these neuropeptides in the pathogenesis of this disease.

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“…According, to the authors the higher level of galanin demonstrated in GDM could be responsible for an adaptation to the rise of glucose and weight associated with GDM. Furthermore, the increased level of galanin is connected with higher BMI before gestation [ 36 ]. In turn, Georgiou et al .…”

Section: Discussionmentioning

confidence: 99%

Lipid profile changes in erythrocyte membranes of women with diagnosed GDM

et al. 2018

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Gestational diabetes mellitus (GDM) is a glucose intolerance that begins or is first recognized during pregnancy. It is currently a growing health problem worldwide affecting from 1% to 14% of all pregnant women depending on racial and ethnic group as well as the diagnostic and screening criteria. Our preliminary study aimed at investigating the erythrocyte membrane fatty acid profiles of pregnant women, in particular with diagnosed with gestational diabetes mellitus (GDM), and with normal glucose tolerant (NGT) pregnant women as a control group. The study group comprised 43 pregnant women, 32 of whom were diagnosed with GDM according to the WHO criteria, and 11 with normal glucose tolerance. The erythrocyte membrane phospholipids were obtained according to the Folch extraction procedure. Fatty acids (FA) were analyzed by gas chromatography (GC) as the corresponding fatty acid methyl esters (FAME). A cluster of 14 fatty acids identified contained >98% of the recognized peaks in the GC analysis. The analysis of fatty acids from erythrocytes revealed important differences between GDM and NGT women in the third trimester, and the results were correlated with biochemical data. Among the 14 measured FA representing the membrane lipidomic profile, the levels of three saturated FA (myristic, palmitic, stearic acids) tended to decrease in GDM patients, with the percentage content of stearic acid significantly changed. The relative content of monounsaturated fatty acids (MUFA) tended to increase, in particular the oleic acid and vaccenic acid contents were significantly increased in erythrocyte membranes of the GDM group in comparison with the NGT group. The GDM group demonstrated higher sapienic acid levels (+29%) but this change was not statistically significant. This study revealed association between an impaired cis-vaccenic acid concentration in erythrocytes membrane and GDM development. No significant changes of polyunsaturated fatty acids (PUFA) were observed in GDM and NGT erythrocytes. We postulate, basing on the differences between the GDM and NGT lipidomic profiles, that stearic and cis-vaccenic acids can be considered as dual biomarkers of specific SFA-MUFA conversion pathway, involving the coupling of delta-9 desaturase and elongase enzymes. Our results indicate that the SFA-MUFA families may be involved in the pathophysiology of metabolic diseases such as GDM, but the further studies are needed to confirm our hypothesis. In conclusion, the erythrocyte membranes of GDM women undergo remodeling resulting in abnormal fatty acid profiles, which are reflection of the long-term status of organism and can have great impact on both the mother and her offspring.

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Association between circulating levels of galanin and pre-pregnancy body mass index in patients with gestational diabetes mellitus

Cited by 11 publications

References 24 publications

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome

Lipid profile changes in erythrocyte membranes of women with diagnosed GDM

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