Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome

Abstract

Objectives: To investigate the serum levels of nesfatin-1 and galanin in patients with metabolic syndrome (MetS), and also to show their association with the parameters of the disease. Methods: We performed a case-control study with 84 participants (44 patients with MetS diagnosed according to the American Heart Association/National Heart, Lung, and Blood Institute and International Diabetes Federation criteria and 40 control group) were recruited from King Abdulaziz University Hospital, Jeddah, Saudi Arabia, between October 2014 and June 2015. Anthropometric parameters, biochemical markers as well as nesfatin-1 and galanin were measured. Results: Nesfatin-1 levels were found to be significantly lower and galanin levels significantly higher in MetS group compared to the control group. A significant negative correlation between serum nesfatin-1 and weight, waist circumference, and body mass index were observed. A significant positive correlation between serum galanin and with fasting blood glucose, glycosylated hemoglobin, homeostasis model assessment-insulin resistance, and triglycerides. Conclusion: Our findings indicated a lower level of nesfatin-1 and a higher level of galanin in patients with MetS, suggesting a role of these neuropeptides in the pathogenesis of this disease.

Nesfatin-1 Hormone Levels in Patients with Antisocial Personality Disorder and Their Relationship with Clinical Variables

“…28 There is a significant negative correlation between the nesfatin-1 hormone and weight and Body Mass Index. 29 Since there was no significant difference between the height and weight of our participants, no relation was found between hormone levels and height/weight. It was found that nesfatin-1 hormone levels in patients with a bipolar disorder-manic period were low in comparison with those of the healthy controls.…”

“…It was found that its secretion decreased during fasting and hunger [ 28 ]. There is a significant negative correlation between the nesfatin-1 hormone and weight and Body Mass Index [ 29 ]. Since there was no significant difference between the height and weight of our participants, no relation was found between hormone levels and height/weight.…”

Does nesfatin-1 influence the hypothalamic–pituitary–gonadal axis in adult males with obstructive sleep apnoea?

“…revealed that nesfatin-1 levels are lower in patients with metabolic syndrome. Additionally, nesfatin-1 correlated inversely with weight, waist circumference, and BMI 13 . There is a suggestion that nesfatin-1 may even serve as an anti-obesity treatment 14,15 .…”

Comments on: Serum nesfatin-1 and galanin concentrations in the adult with metabolic syndrome.

“…Nesfatin is a potent anorectic neuropeptide which plays an important role in food intake and energy expenditure. 1 , 2 It has been linked to depression and coronary plaque. 1 , 2 While galatin is neuropeptide which is widely expressed in the brain and hypothalamus.…”

“… 1 , 2 It has been linked to depression and coronary plaque. 1 , 2 While galatin is neuropeptide which is widely expressed in the brain and hypothalamus. Both neuropeptides play an important role in regulation of energy balance and modulation of food intake.…”