Objectives: To investigate the serum levels of nesfatin-1 and galanin in patients with metabolic syndrome (MetS), and also to show their association with the parameters of the disease. Methods: We performed a case-control study with 84 participants (44 patients with MetS diagnosed according to the American Heart Association/National Heart, Lung, and Blood Institute and International Diabetes Federation criteria and 40 control group) were recruited from King Abdulaziz University Hospital, Jeddah, Saudi Arabia, between October 2014 and June 2015. Anthropometric parameters, biochemical markers as well as nesfatin-1 and galanin were measured. Results: Nesfatin-1 levels were found to be significantly lower and galanin levels significantly higher in MetS group compared to the control group. A significant negative correlation between serum nesfatin-1 and weight, waist circumference, and body mass index were observed. A significant positive correlation between serum galanin and with fasting blood glucose, glycosylated hemoglobin, homeostasis model assessment-insulin resistance, and triglycerides. Conclusion: Our findings indicated a lower level of nesfatin-1 and a higher level of galanin in patients with MetS, suggesting a role of these neuropeptides in the pathogenesis of this disease.
Introduction Falls in elderlies are one of the leading causes of emergency visits worldwide. It is also a major cause of morbidity and mortality and imposes a significant burden on health care costs. This study investigates risk factors in elderlies aged 65 and above that contribute to falls. Methodology This study is a cross-sectional study using a non-probability consecutive sampling technique. The records of 300 clinical data of elderly who underwent falls were collected from all confirmed cases of falls from January 2015 to January 2020, at National Guard Hospital in Jeddah, Kingdom of Saudi Arabia. Results Patients included in this study were ranged in age from 65 to 85 years with a mean age of 77.6 years (SD = 8.1 years). Among our population, 149 (53.4%) were males, and 130 (46.6%) were females. Some comorbidities were associated with our population such as diabetes mellitus (69.2%, n = 193), hypertension (75.3%, n = 210), smoking (6.1%, n = 6.1), and polypharmacy (18.3%, n = 51). Conclusion Understanding and evaluating risk factors can help to decrease or even prevent falls. Smoking and dementia are strongly related to increased mortality rate. Some outcomes of falls such as head injuries and ICU admission had a strong association to increased mortality. Physical therapy or occupational therapy found to be a strong factor to decrease fall recurrence.
Managing patients with T1DM who fast Ramadan is challenging. The COVID-19 related strict imposed curfew in Saudi Arabia affected access to healthcare and made virtual education (VD) a necessity. Objective: To assess the impact of VD on glycemic control and self-management in T1DM during Ramadan fasting. Methods: Pre-post Ramadan survey at endocrine clinics of National Guards Hospital, Jeddah, Saudi Arabia. Patients were contacted by phone due to COVID 19 restrictions. The VD methods (video + booklet) were sent to patients via WhatsApp. HbA1c was measured before and after Ramadan. Results: 89 patients enrolled: 51.2% males, DM duration 13.8 ±7.7 years, age 24.4 ±8.1 years. > 90% stated that VD used was well done/acceptable, and 57% confirmed using it as reference. During Ramadan 88% complied with frequent SMBG, 72.6% reported breaking the fast at the recommended threshold of <70mg/dl, but only 22.6% broke fasting if >300 mg/dL. 61% followed the recommended insulin adjustments to basal and sahoor doses, and to adjustment of meal timings (delay of sahoor), and fluid intake. 43% complied with eating proteins at sahoor. Baseline HbA1c 8.46 ±1.85 and decreased to 8.32 ±1.47 after the intervention process (P=0.004). Conclusion: Diabetes virtual education was well received and improved glycemic control and self-care among patients with T1DM during Ramadan fasting. Disclosure G. S. Khogeer: None. R. Alamoudi: None. M. N. Alotibi: None.
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