Assessment of wound area reduction on chronic wounds in dogs with photobiomodulation therapy: A randomized controlled clinical trial

Abstract

Background and Aim: Chronic wounds are a clinical problem and require intensive standard wound care. However, this is sometimes insufficient to promote healing. Photobiomodulation therapy (PBMT) can be used as an adjunctive therapy to improve wound healing. Various PBMT devices with different properties and parameter settings as well as different animal species can influence a variety of clinical outcomes. This study aims to assess the use of 830 nm PBMT or simultaneous superpulsed and multiple wavelengths (SPMW; 660, 875, and 905 nm) PBMT on chronic wounds in client-owned dogs. Materials and Methods: This study included 21 client-owned dogs with chronic wounds allocated into three groups: (1) Control group (C) treated with irrigated saline and without PBMT (n=7); (2) L1 group treated with irrigated saline together with the radiation of 830 nm PBMT (n=7); and (3) L2 group treated with irrigated saline together with the radiation of simultaneous SPMW-PBMT (n=7). Wound healing was assessed on the basis of wound size reduction as a percentage of wound area every 2nd day for 15 days using image analysis software (ImageJ software®, National Institutes of Health, Rockville, Maryland, USA). Results: A significant difference in the percentage of wound area reduction was noted between the C and PBMT groups (L1 and L2; p<0.05). The average percentages of wound area reduction at the end of the study (15 days) were 42.39±20.58, 56.98±24.82, and 61.81±27.18 in the C, L1, and L2 groups, respectively. A steady decrease in wound size was noted in both PBMT and non-PBMT groups, and coefficients were 7.77, 8.95, and 10.01 in the C, L1, and L2 groups, respectively. The percentage of wound area reduction was found to be significantly different between the PBMT and non-BPMT groups on day 7 (p<0.05). Conclusion: Based on the results of the current study, using either 830 nm PBMT or simultaneous SPMW-PBMT can accelerate the chronic wound healing process in dogs with a significant reduction in wound area. Therefore, it can be used as an adjunctive therapy to improve wound healing in dogs with reduced treatment duration.

The use of photobiomodulation therapy in the treatment of hair cycle arrest in a Pembroke Welsh corgi

“…Similar wavelengths were used with the MR4 ActiVet Pro laser in a clinical trial assessing wound area reduction on chronic wounds in dogs with PBMT, revealing significant difference in the percentage of wound area reduction between the control and PBMT groups. 19 For optimum penetration depth and consistent dosing for the patient described herein, the direct contact technique was employed. Direct contact was made with each affected region (bilateral caudal thighs and bilateral dorsal thoracolumbar region) for 5 minutes, for a total of 20 minutes of laser therapy per session.…”

“…The MR4 ActiVet Pro, MultiRadiance Medical laser (Solon, OH, USA) was used at 250 Hz with probe emitting wavelengths of 905, 860, 660 and 465 nm. Similar wavelengths were used with the MR4 ActiVet Pro laser in a clinical trial assessing wound area reduction on chronic wounds in dogs with PBMT, revealing significant difference in the percentage of wound area reduction between the control and PBMT groups 19 . For optimum penetration depth and consistent dosing for the patient described herein, the direct contact technique was employed.…”

Photobiomodulation therapy combined with static magnetic field in tibial fracture healing of a dog: A case report

“…To date, was observed that the use of PBMT is associated with increased peak vertical force after tibial plateau levelling osteotomy (Rogatko et al., 2017 ) and improvement of function after surgical correction of a herniated disc in dogs (Draper et al., 2012 ). In addition, it was observed that PBMT may accelerate chronic wound healing process in dogs (Hoisang et al., 2021 ) and reduce lameness, pain and non‐steroidal anti‐inflammatory drugs (NSAIDs) use on canine osteoarthritis (Looney et al., 2018 ). Finally, there is evidence that PBMT has a potential as a biostimulator, inducing bone formation during distraction osteogenesis in dogs, resulting in shorter treatment time and improved quality and quantity of new bone (Taha et al., 2018 ).…”

Therapy of Extensive Chronic Skin Defects after a Traumatic Injury Due to Microbial Contamination Using a Surface Implant Made of a Biocompatible Polycaprolactone—A Pilot Case Study

“…Polycaprolactone is a polymeric biocompatible material that, in its medical degree of purity, is used for various purposes in human medicine, too [ 16 ]. Due to its optimal mechanical properties, polycaprolactone has great biopotential in the biomedical applications of tissue engineering [ 17 ]. Several studies also refer to the choice of polycaprolactone as a suitable material for use in the present case study [ 17 , 18 ] and mechanical properties [ 19 , 20 ].…”

“…Due to its optimal mechanical properties, polycaprolactone has great biopotential in the biomedical applications of tissue engineering [ 17 ]. Several studies also refer to the choice of polycaprolactone as a suitable material for use in the present case study [ 17 , 18 ] and mechanical properties [ 19 , 20 ].…”