Remission of diabetes mellitus in dogs is a very rare condition. In our case, the clinical signs of diabetes mellitus in the nine-year-old Yorkshire terrier bitch disappeared three months after a therapeutic ovariohysterectomy. The diagnosis of diestrous diabetes mellitus, requiring insulin supplementation, was confirmed on the basis of anamnesis, symptomatology, clinical examination and specific laboratory tests. The chosen therapy and a change in diet led to the stabilization of the patient and its preparation for surgery. Repeated follow-ups, consisting of control blood samplings for glucose and progesterone levels and urinanalysis, has ensured control of insulin therapy and proper insulin dosing. Three weeks after ovariohysterectomy, normoglycaemia, confirmed by control trials, resulted in gradual discontinuation of insulin administration. The stable health status of the patient two months after the performance of therapeutic ovariohysterectomy confirmed the remission of the disease without the need for further insulin supplementation and regular monitoring.
Babesia gibsoni is a tick-borne protozoal blood parasite that may cause hemolytic anemia, thrombocytopenia, lethargy, and/or splenomegaly in dogs. Many drugs have been used in management of canine babesiosis such as monotherapy or combined treatment, including diminazene aceturate, imidocarb dipropionate, atovaquone, and antibiotics. This report examines the effectiveness and safety of Malarone®, azithromycin (AZM) and artesunate (ART) combination for the treatment of babesiosis in dogs naturally infected with Babesia gibsoni. Twelve American Pit Bull Terriers were included in the experiment. Examined dogs underwent clinical and laboratory analysis including hematology and biochemistry profile and serum protein electrophoresis. After diagnosis, the dogs received combined therapy with Malarone® (13.5 mg/kg PO q24 h), azithromycin (10 mg/kg PO q24 h) and artesunate (12.5 mg/kg PO q24 h) for 10 days. The combined treatment improved hematology and biochemical parameters to the reference range gradually during the first 14 days already, resulting in the stable values until day 56 after treatment. No clinically apparent adverse effects were reported during treatment and monitoring. No relapses of parasitemia were detected in control days 180, 360, 540 and 720 in all dogs. Results of the study indicate that the combined treatment leads to successful elimination of parasitemia in chronically infected dogs with B. gibsoni.
The occurrence of extensive non-healing and chronic skin defects with loss of tissue substance in companion animals are a frequently solved problem. The management of the therapy of large-area defects and absent tissues is a challenge for setting up successful therapeutic management and achieving wound closure, satisfactory cosmetic effect, and restoration of the functionality of the damaged area. In veterinary medicine, we often encounter the failure of wound therapy methods commonly used in closing defects, as a result of which the defect closure time is prolonged. The longer the time required to close the defect, the greater the risk of microbial infection and complications associated with healing in the case of extensive damage to the surrounding soft tissues. Direct influence of the individual phases of healing with supportive alternative therapy appears to be a very suitable solution for the treatment of chronic wounds. To overcome the shortcomings related to partially efficient conventional wound dressings, efforts are oriented toward developing new and effective platforms for wound healing applications. Five patients referred to the Small Animal Clinic of the University Veterinary Hospital were included in this clinical study. Patients were referred to the clinic with extensive long-term non-healing wounds, necrosis and secernation, or ongoing infection, with loss of tissue substance, which showed signs of chronicity. After assessing the patient’s state of health and subsequent cleaning of the wound bed from contaminants and damaged tissues, collagen sponge Suprasorb® C was applied to the surface of the cleaned wound bed. The average time for the complete closure of the defect was 24.6 days since the introduction of the primary treatment. In all patients, we observed the complete closure of the defect, restoration of functionality of the damaged tissues, and achievement of a cosmetic effect without complications in the recovery process, which points to the excellent effectiveness of the collagen covering in the wound healing process.
This case study describes the use of additive manufacturing technology combining a biodegradable polymer material, polycaprolactone (PCL), and innovative procedures for creating superficial wound dressing, a scaffold in the therapy of extensive contaminated skin defects caused by a traumatic injury. Chronic and contaminated wounds represent a clinical problem and require intensive wound care. The application of a temporary scaffold-facilitated bridging of the wound edges resulted in faster tissue regeneration and a shorter defect closure time, compared to other conservative and surgical methods used in therapy of chronic wounds. Although this procedure has proven to be an optimal alternative to autologous transplants, further studies with a larger number of patients would be beneficial.
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