Assessment of Toxic Effects of Ochratoxin A in Human Embryonic Stem Cells

Erceg, Slaven; Mateo, Eva M.; Zipančić, Ivan; Jiménez, Francisco Javier Rodríguez; Aragó, Maria Amparo Pérez; Jiménez, Misericordia; Soria, José Miguel Guillén; Garcia-Esparza, Ma. Angeles

doi:10.3390/toxins11040217

Cited by 17 publications

(16 citation statements)

References 56 publications

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“…There are some data on mycotoxicoses in children, infants, and even in embryonic stage, but these topics definitely need additional attention from the scientific community. Using human embryonic stem cells (hESCs), a research group showed the dose dependency of OTA toxicity (Erceg et al, 2019). More data could give us a clearer view on how different mycotoxin exposures affect the differentiation of hESC cells.…”

Section: The Risks Of Mycotoxins At Different Stages Of Lifementioning

confidence: 99%

Toxicological and Medical Aspects of Aspergillus-Derived Mycotoxins Entering the Feed and Food Chain

et al. 2020

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Background: A atoxins are major contaminants of feed used in poultry industry that negatively affect animal and human health. In Ethiopia, previous studies on a atoxins mainly considered cattle feed and milk, but scarce information exists for poultry feeds. Method: The aim of this study was to determine the burden of a atoxin in poultry feed in bishoftu.Cross sectional study was conducted from December, 2018 to May, 2019and 33 compound poultry feed samples were randomly collected from chicken rearing villages of Bishoftuand analyzed for G2, G1, B2 , B1 and total a atoxins using HPLC. Results: The result indicated thatfrom a total of 33 samples 31(94%) samples were contaminated with a atoxin. The mean level of a atoxin G2, G1, B2, B1 and total a atoxinswere 18.00 µg/g, 88.5499 µg/g, 13.50µg/g, 70.11µg/g and 190.18µg/g respectively. This study curtained the level of a atoxinin 25 (72.75%) samples for AFT and 22 (66.67%) samples for AFB1 were above the limit of FDA regulatory levels of 20µg/g for poultry feed. Conclusion: The study showed the high contamination of a atoxins in poultry feed. The study warrants the need for preventive strategies of a atoxin contamination including implementation of regulatory legislation in poultry feeds in Bishoftu.

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Section: The Risks Of Mycotoxins At Different Stages Of Lifementioning

confidence: 99%

Toxicological and Medical Aspects of Aspergillus-Derived Mycotoxins Entering the Feed and Food Chain

et al. 2020

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“…OTA-contaminated foods, especially plant foods, were related to the occurrence of many diseases in animals and humans, and it was a potential health threat with nephrotoxicity, hepatotoxicity, teratogenicity, immunotoxicity and neurotoxicity [ 43 ]. More and more research results indicated that even a very low level of OTA intake will accumulate in the human body [ 44 , 45 ]. The acute toxicity of OTA showed wide variability, which is related to animal sex, species and sample size.…”

Section: Occurrence Contamination and Toxicity Of Mycotoxinsmentioning

confidence: 99%

Contamination, Detection and Control of Mycotoxins in Fruits and Vegetables

Nan

Xue

2022

Toxins

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Mycotoxins are secondary metabolites produced by pathogenic fungi that colonize fruits and vegetables either during harvesting or during storage. Mycotoxin contamination in fruits and vegetables has been a major problem worldwide, which poses a serious threat to human and animal health through the food chain. This review systematically describes the major mycotoxigenic fungi and the produced mycotoxins in fruits and vegetables, analyzes recent mycotoxin detection technologies including chromatography coupled with detector (i.e., mass, ultraviolet, fluorescence, etc.) technology, electrochemical biosensors technology and immunological techniques, as well as summarizes the degradation and detoxification technologies of mycotoxins in fruits and vegetables, including physical, chemical and biological methods. The future prospect is also proposed to provide an overview and suggestions for future mycotoxin research directions.

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“…Because of its thermal stability, it can also be found in heat‐treated food products (Gambacorta et al., 2018). OTA has been shown to have pathogenesis of various forms of human nephropathies such as kidney cancer (Erceg et al., 2019). Therefore, because of the side effects of this toxin on human health and the economic losses caused by food products contamination, it is essential to reduce the risk of contact to this compound, typically during preventive assesses including proper treatment of plant products through pre‐harvest, harvest, and post‐harvest.…”

Section: Introductionmentioning

confidence: 99%

Kinetics and mathematics modeling of ochratoxin a detoxification in maize dough by Lacticaseibacillus casei subs. casei subjected to continuous and pulsed ultrasound

Hashemi

Roohi

Abedi

et al. 2021

J. Food Process. Preserv.

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The Lacticaseibacillus casei subsp. casei growth and ochratoxin A removal during fermentation of maize dough were mathematically modeled using the Baranyi and statistical models of Weibull and modified Gompertz models, respectively. The effect of important detoxification parameters including temperature level (35 and 37°C), sonication duration (0, 5, 10 and 15 min) as well as continuous/pulsed ultrasound treatment was investigated. According to the obtained results, the utilization of the pulsed sonication can improve the performance of the conducted treatment in comparison to the continuous case for 15 min duration of sonication. However, for lower periods of sonication (i.e., 5 and 10 min), the continuous sonication was proved to be more efficient in detoxification process. It was observed 2°C temperature increase lead to an average 4.33 µg/kg reduction of the Ochratoxin A after 48 hr fermentation from the sonication. Practical applications Microbial decontamination may give probable elimination of mycotoxins in food products under mild conditions, therefore preventive important losses in the quality of food products. Biological degradation of ochratoxin A under pulsed and continuous ultrasound was modeled. It was observed 2°C temperature increase lead to an average 4.33 µg/kg reduction of the Ochratoxin A after 48 hr fermentation from the sonication. Therefore, biological detoxification under optimal ultrasound treatment is an effective and rapid way to degrade ochratoxin A in maize dough.

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Assessment of Toxic Effects of Ochratoxin A in Human Embryonic Stem Cells

Cited by 17 publications

References 56 publications

Toxicological and Medical Aspects of Aspergillus-Derived Mycotoxins Entering the Feed and Food Chain

Toxicological and Medical Aspects of Aspergillus-Derived Mycotoxins Entering the Feed and Food Chain

Contamination, Detection and Control of Mycotoxins in Fruits and Vegetables

Kinetics and mathematics modeling of ochratoxin a detoxification in maize dough by Lacticaseibacillus casei subs. casei subjected to continuous and pulsed ultrasound

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