Assessment of serum bilirubin and hepatic enzymes in malaria patients

Jha, Sudha; Shrestha, Shailaza; Gole, Sheetal G.; Deep, Gagan

doi:10.7439/ijbar.v5i3.710

Cited by 3 publications

(6 citation statements)

References 10 publications

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“…These changes in hepatocytes may lead to the leakage of parenchymal (transaminases) and membranous (alkaline phosphatase) enzymes of the liver to the circulation. Hence increase in liver enzymes AST, ALT and ALP observed in malaria infected patients (15) . The elevation in serum activities of hepatic enzymes; transaminases and alkaline phosphatase are the markers of liver damage.…”

Section: Discussionmentioning

confidence: 93%

“…The elevation in serum activities of hepatic enzymes; transaminases and alkaline phosphatase are the markers of liver damage. SGPT is a specific enzyme of liver (15,10,16) . The earlier studies reported a significant reduction in hemoglobin concentration and significant elevation in serum bilirubin, AST and ALT in patients with malaria as compared to control (1,15,10,17) .…”

Section: Discussionmentioning

confidence: 99%

“…SGPT is a specific enzyme of liver (15,10,16) . The earlier studies reported a significant reduction in hemoglobin concentration and significant elevation in serum bilirubin, AST and ALT in patients with malaria as compared to control (1,15,10,17) . Our study indicates that liver enzymes AST and ALT were significantly increases in malaria patients as compared to control subjects.…”

Section: Discussionmentioning

confidence: 99%

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Hematological and Some Liver Function Tests In Patients with Malaria

Shikhare¹

2017

jmscr

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hematological and Some Liver Function Tests In Patients with Malaria

Shikhare¹

2017

jmscr

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“…Bilirubin levels are usually increased in malarial patients [87]. UCB, although has a cyto-protective role, the cytotoxic effect of UCB to RBCs, peripheral blood mononuclear cells, immune cells and to neuronal and non-neuronal tissue has been observed [84, 88–91].…”

Section: Discussionmentioning

confidence: 99%

“…The ability of heme to complex with serum albumin [ 84 ] disturbs the normal transport pathway of unconjugated bilirubin (UCB) to the liver for conjugation and further excretion from the body. Bilirubin levels are usually increased in malarial patients [ 87 ]. UCB, although has a cyto-protective role, the cytotoxic effect of UCB to RBCs, peripheral blood mononuclear cells, immune cells and to neuronal and non-neuronal tissue has been observed [ 84 , 88 – 91 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum

et al. 2017

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Multiple mechanisms such as genetic and epigenetic variations within a key gene may play a role in malarial susceptibility and response to anti-malarial drugs in the population. ABCB1 is one of the well-studied membrane transporter genes that code for the P-glycoprotein (an efflux protein) and whose effect on malaria disease predisposition and susceptibility to drugs remains to be understood. We studied the association of single nucleotide variations in human ABCB1 that influences its function in subjects with uncomplicated and complicated malaria caused by Plasmodium falciparum (Pf). Global DNA methylation and ABCB1 DNA promoter methylation levels were performed along with transcriptional response and protein expression in subjects with malaria and healthy controls. The rs2032582 locus was significantly associated with complicated and combined malaria groups when compared to controls (p < 0.05). Significant DNA methylation difference was noticed between case and control (p < 0.05). In addition, global DNA methylation levels of the host DNA were inversely proportional to parasitemia in individuals with Pf infection. Our study also revealed the correlation between ABCB1 DNA promoter methylation with rs1128503 and rs2032582 polymorphisms in malaria and was related to increased expression of ABCB1 protein levels in complicated malaria group (p < 0.05) when compared to uncomplicated malaria and control groups. The study provides evidence for multiple mechanisms that may regulate the role of host ABCB1 function to mediate aetiology of malaria susceptibility, prognosis and drug response. These may have clinical implications and therapeutic application for various malarial conditions.

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Thrombocytopenia and Elevated Alanine Aminotransferase Levels in Malaria Patients

Gilani¹,

Khan²,

Khan³

et al. 2021

PAFMJ

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Objective: To study thrombocytopenia and elevated ALT levels in malaria patients reporting to Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa. Study Design: Cross sectional study. Place and Duration of Study: Departments of Pathology and Medicine, Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa, from Feb 2015 to Dec 2016. Methodology: In total of 100 febrile patients of both gender and all ages reported to Pak Med Level II+ Hospital XII and XIII, Liberia with clinical features of malaria and having positive malarial parasite (MP) on any of the methods of immune chromatography (ICT) or microscopic film were included. The febrile patients with typical clinical features of malaria but having negative MP both on ICT and microscopic methods were excluded.Pretreatment whole blood in EDTA was collected for testing MP on ICT and by microscopic method including MP index and platelets, while serum for ALT. Results: Out of total 100 patients, 75 were males, 25 females with mean age of 38 ± 5 years. MP was found positive on MP film in 95% and on ICT in 88% cases. Thrombocytopenia was found in 69% and ALT was elevated in 60% cases. Mean and SD for platelets count was 129 ± 72 x 109/L and of ALT 76 ± 66 U/L. Mean of MP index was 0.49 ranging from 0 to 3.5%. Correlation of MP index with platelets and ALT was found insignificant, although in malaria patients, platelets and ALT was inversely correlated significantly with each other showing low platelets along with elevated ALT levels. Conclusion: In malaria patients, thrombocytopenia and elevated ALT are frequent findings, which may not definitely correlate with MP index. So it is advisable to test for platelet count and ALT in all patients of malaria for early diagnosis and better management.

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Assessment of serum bilirubin and hepatic enzymes in malaria patients

Cited by 3 publications

References 10 publications

Hematological and Some Liver Function Tests In Patients with Malaria

Hematological and Some Liver Function Tests In Patients with Malaria

Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum

Thrombocytopenia and Elevated Alanine Aminotransferase Levels in Malaria Patients

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