The case of 38-month-old boy is being reported who was brought to the pediatrics clinic with fever, cough, hemoptysis, and breathing difficulty. Imaging studies revealed a right lower chest mass. Lobectomy and histopathological examination revealed it to be predominantly solid pleuropulmonary blastoma type II. It is a rare pediatric pleuropulmonary tumor with aggressive behavior and tendency to spread to the brain. The case is being presented to make the general histopathologist aware of this rare entity and to highlight to the pediatric physicians/surgeons, radiologists, and histopathologists the fact that lung cysts in infants and young children should be evaluated seriously and sampled thoroughly to diagnose cases of type I pleuropulmonary blastoma which will progress over time to type II or type III tumors. Also the siblings and first degree relatives of the patient should be screened for associated pulmonary and extrapulmonary benign and malignant conditions.
Ganglioneuromas (GN) are rare, benign neurogenic tumors that arise from sympathetic ganglia. They are often asymptomatic. However, in rare cases, they may secrete catecholamines, vasoactive intestinal polypeptides (VIP), or androgenic hormones and manifest with flushing, symptoms of catecholamine excess or chronic diarrhea. We report a young Saudi girl with chronic secretory diarrhea, severe hypokalemia and abdominal distension. After an extensive work up, a well-defined hypodense heterogeneous mediastinal mass was noted in radio imaging. A complete recovery was seen after surgical removal of that mediastinal mass which turned to be a ganglioneuroma.
Vascular headache and chronic rhinosinusitis (CRS) are diseases that share similar symptoms and demographics, including headache, facial pain and nasal symptoms. Contribution of chronic sinusitis as a cause of chronic headache is controversial, as there are scarce studies to know incidence of vascular headache in patients with CRS. To evaluate incidence of vascular headache in patients with CRS. Using descriptive study design, group of 100 patients with symptoms of CRS with headache were included in study. Patients underwent surgical management and 3% managed medically. Patients were assessed for associated factors with headache and further evaluated for persistence of headache postoperatively. Inferential statistics was done by Chi square test using SPSS for Windows Software (Version 21.0). Leading symptoms of CRS were headache (100%), nasal obstruction (93%), and nasal discharge (90%). Pre-treatment 25% had exposure to sunlight as aggravating factor and associated nausea vomiting in 30%. Post-treatment, follow-up at 6 months, 20% reported persisting headache, with duration of headache >1 year in 37.5% ( = 0.01). Those with pre-operative sunlight exposure as aggravating factor, headache persisted in 60% ( < 0.0001) and those with nausea/vomiting pre-treatment; headache persisted in 56.7% ( < 0.0001). These results were statistically significant. In CRS patients who had other factors contributing to headache like duration of headache more than 1 year, associated nausea/vomiting, and aggravating factors like exposure to sunlight, headache persisted after medical and surgical treatment of CRS. It signifies that 20% CRS patients with headache were having co existing vascular headache.
Objective: To study thrombocytopenia and elevated ALT levels in malaria patients reporting to Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa. Study Design: Cross sectional study. Place and Duration of Study: Departments of Pathology and Medicine, Pak Med Level II+ Hospital XII and XIII, UN Mission Liberia, West Africa, from Feb 2015 to Dec 2016. Methodology: In total of 100 febrile patients of both gender and all ages reported to Pak Med Level II+ Hospital XII and XIII, Liberia with clinical features of malaria and having positive malarial parasite (MP) on any of the methods of immune chromatography (ICT) or microscopic film were included. The febrile patients with typical clinical features of malaria but having negative MP both on ICT and microscopic methods were excluded.Pretreatment whole blood in EDTA was collected for testing MP on ICT and by microscopic method including MP index and platelets, while serum for ALT. Results: Out of total 100 patients, 75 were males, 25 females with mean age of 38 ± 5 years. MP was found positive on MP film in 95% and on ICT in 88% cases. Thrombocytopenia was found in 69% and ALT was elevated in 60% cases. Mean and SD for platelets count was 129 ± 72 x 109/L and of ALT 76 ± 66 U/L. Mean of MP index was 0.49 ranging from 0 to 3.5%. Correlation of MP index with platelets and ALT was found insignificant, although in malaria patients, platelets and ALT was inversely correlated significantly with each other showing low platelets along with elevated ALT levels. Conclusion: In malaria patients, thrombocytopenia and elevated ALT are frequent findings, which may not definitely correlate with MP index. So it is advisable to test for platelet count and ALT in all patients of malaria for early diagnosis and better management.
Acute appendicitis is a common cause of acute surgical abdomen and many appendectomies are performed daily. All disease processes involving appendix will present as acute appendicitis. Clinically diagnosed acute appendicitis is treated by urgent appendectomy. As most of the removed appendices will reveal acute suppurative inflammation, therefore, appendectomy specimens are not usually submitted for histopathological examination unless the surgeon notices advanced disease or grossly recognizable abnormalities. Objectives: The purpose of this study is; 1, to explore the spectrum of diseases affecting the appendix in the community; 2, to find the age and gender association of appendicular diseases; and 3, to see if all the surgically removed appendices should be submitted for histopathological examination as a routine procedure. Study Design: Retrospective study. Setting: Charsada Teaching Hospital affiliated with Jinnah Medical College Peshawar. Period: January 2013 to January 2016. Methods: The histology slides and diagnoses of all the retrieved cases were reviewed with regards to morphology, patient's age, gender and presence or absence of any associated disease. Results: Nine disease entities were identified affecting the appendix, which from most to least common were acute suppurative appendicitis, lymphoid hyperplasia, fecalith, fibrous luminal obliteration, oxyuriasis, carcinoid tumor, submucosal fibrosis, acquired diverticulosis, and inflammatory mucocele. The first three commonest diseases were most frequent in the second decade of life; fibrous luminal obliteration in the fourth decade, carcinoid tumors in the third decade, and oxyuriasis in the first decade. Moreover, acute suppurative appendicitis, fecalith, oxyuriasis, and submucosal fibrosis were more frequent in males; whereas, lymphoid hyperplasia and fibrous luminal obliteration were more common in females. Conclusions: Acute suppurative appendicitis was the most common histological diagnosis. Acute suppurative appendicitis, fecalith, oxyuriasis, and submucosal fibrosis were more common in males; whereas, lymphoid hyperplasia and fibrous luminal atresia were more common in females. Acute suppurative appendicitis, lymphoid hyperplasia, and fecalith were most common in the second decade of life. In view of the nine different histological disease entities identified in this study under one clinical diagnosis of acute appendicitis, it is highly recommended to submit all appendectomy specimens for histopathological examination.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.