Assessment of Melatonin and Its Precursors Content by a HPLC-MS/MS Method from Different Romanian Wines

Albu, Camelia; Radu, Letiţia Elena; Radu, Gabriel Lucian

doi:10.1021/acsomega.0c03463

Cited by 12 publications

(6 citation statements)

References 35 publications

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“…A moderate amount of alcohol from wine consumption (150-300 mL/day) can protect against cardiovascular disease, dietary cancers, ischemic stroke, diabetes, hypertension and so on [50]. Additionally, the polyphenols from wine have antioxidant, antiviral, antibacterial and anti-carcinogen proprieties which imply health benefits [50][51][52][53]. Apart this, vine and wine has an important economic status, including in the world trade market as well as the agro-tourism to wineries and wine-growing areas.…”

Section: Introductionmentioning

confidence: 99%

Helium Atmospheric Pressure Plasma Jet Source Treatment of White Grapes Juice for Winemaking

Huzum

Nastuta

2021

Applied Sciences

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In the last few years, new emerging technologies to develop novel winemaking methods were reported. Most of them pointed out the need to assess the barrel aging on the wine product, fermentation process, green technologies for wine treatment for long term storage. Among these, plasma technologies at atmospheric pressure are on the way of replacing old and expensive methods for must, wine and yeast treatment, the goal being the long-term storage, aging and even decontamination of such products, and seems to meet the requirements of the winemakers. Using the principles of dielectric barrier discharge, we power up an atmospheric pressure plasma jet in helium. This plasma is used for treatment of fresh must obtained from white grapes. Our research manuscript is focused on the correlation of plasma parameters (applied voltage, plasma power, reactive species, gas temperature) with the physico-chemical properties of white must and wine (1 and 2 years old), via ultraviolet–visible and infrared spectroscopy, and colorimetry. Two types of white must were plasma treated and studied over time. The 10 W plasma source did not exceed 40 °C during treatment, the must did not suffer during thermal treatment. A higher quantity of RONS was observed during plasma-must exposure, supporting further oxidation processes. The UV-Vis and FTIR spectroscopy revealed the presence of phenols, flavones and sugar in the wine samples. Simultaneous visualization of CIE L*a*b* and RGB in color space charts allows easier understanding of wine changing in color parameters. These experimental results supporting the possible usability of atmospheric pressure plasma for winemaking.

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Section: Introductionmentioning

confidence: 99%

Helium Atmospheric Pressure Plasma Jet Source Treatment of White Grapes Juice for Winemaking

Huzum

Nastuta

2021

Applied Sciences

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“…We also developed a protocol to specifically induce depression by employing the set of restrain-related stressors. We defined this regimen as chronic unpredictable mild restraint (CUMR), which is based on and further advances the widely used chronic unpredictable mild stress (CUMS) protocol [13, 14, 24]. Major difference between CUMR and CUMS is the exclusion of rhythm disturbances such as food deprivation, group housing and stroboscopic illumination.…”

Section: Resultsmentioning

confidence: 99%

Novel Murine models of Mania and Depression

Chen

Xia

et al. 2022

Preprint

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Neuropathological mechanisms triggering manic syndrome or manic episodes in bipolar disorder remain poorly characterised, as the research progress is severely limited by the paucity of appropriate animal models. Here we developed a novel manic mice model by combining a series of chronic unpredictable rhythm disturbances (CURD), which include disruption of circadian rhythm, sleep deprivation, exposure to cone light, with subsequent interference of followed spotlight, stroboscopic illumination, high temperature stress, noise disturbance and foot shock. To validate this novel manic model, we used multiple behavioural and cell biology approaches comparing the CURD-model with healthy controls and depressed mice. The depression model was created by an exposure to an improved chronic unpredictable mild stress, which we defined as chronic unpredictable mild restraint (CUMR). A novel manic mice model induced by environmental stressors and free from genetic or pharmacological interventions will benefit research into pathological mechanisms of mania.

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“…Besides phenolic compounds, melatonin has also been identified in wines, and its presence might be responsible for its role in putative wine health benefits [ 32 , 33 , 34 , 35 ].…”

Section: Wine Bioactive Compounds: Modulation Of Biochemical Pathways...mentioning

confidence: 99%

Moderate Wine Consumption and Health: A Narrative Review

et al. 2022

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Although it is clearly established that the abuse of alcohol is seriously harmful to health, much epidemiological and clinical evidence seem to underline the protective role of moderate quantities of alcohol and in particular of wine on health. This narrative review aims to re-evaluate the relationship between the type and dose of alcoholic drink and reduced or increased risk of various diseases, in the light of the most current scientific evidence. In particular, in vitro studies on the modulation of biochemical pathways and gene expression of wine bioactive components were evaluated. Twenty-four studies were selected after PubMed, Scopus and Google Scholar searches for the evaluation of moderate alcohol/wine consumption and health effects: eight studies concerned cardiovascular diseases, three concerned type 2 diabetes, four concerned neurodegenerative diseases, five concerned cancer and four were related to longevity. A brief discussion on viticultural and enological practices potentially affecting the content of bioactive components in wine is included. The analysis clearly indicates that wine differs from other alcoholic beverages and its moderate consumption not only does not increase the risk of chronic degenerative diseases but is also associated with health benefits particularly when included in a Mediterranean diet model. Obviously, every effort must be made to promote behavioral education to prevent abuse, especially among young people.

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Assessment of Melatonin and Its Precursors Content by a HPLC-MS/MS Method from Different Romanian Wines

Cited by 12 publications

References 35 publications

Helium Atmospheric Pressure Plasma Jet Source Treatment of White Grapes Juice for Winemaking

Helium Atmospheric Pressure Plasma Jet Source Treatment of White Grapes Juice for Winemaking

Novel Murine models of Mania and Depression

Moderate Wine Consumption and Health: A Narrative Review

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