Assessment of intermittent claudication by quantitation of exercise induced microalbuminuria

Hickey, N C; Shearman, C.P.; Gosling, Peter; Simms, M. H.

doi:10.1016/s0950-821x(05)80815-1

Cited by 45 publications

(19 citation statements)

References 11 publications

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“…Most studies show that ACR at rest is no different between claudicants and control subjects, 19,52 although other studies using the same methods have shown a higher resting ACR in claudicants. 73 The finding in the latter study may possibly be explained by the wide variation (up to 10 3 ) in ACR levels. If parametric statistical analyses were used, this would perhaps report a much higher level for mean ACR within a patient group in comparison with the median score.…”

Section: Assessment Of Vascular Endothelial Damage Following Ischaemimentioning

confidence: 65%

“…the increase in vascular permeability, correlates with an increase in serum lipid peroxides, 19 an increase in anti-oxidant consumption, 24 neutrophil activation and degranulation, 51,52 and Doppler ankle pressure recovery time. 73 The effect of therapeutic intervention in claudicants on vascular permeability can also be determined. Tsang et al 75 showed that pentoxyfylline (a drug with properties that decrease neutrophil activation) attenuated the post-exercise increase in ACR.…”

Section: Assessment Of Vascular Endothelial Damage Following Ischaemimentioning

confidence: 99%

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Biochemical and inflammatory changes in the exercising claudicant

Tisi

Shearman

1998

Vasc Med

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Intermittent claudication is an early manifestation of atherosclerosis in the leg. The prognosis for the claudicating limb is reasonably good, but patients have excess cardiovascular morbidity and mortality rates compared with a control population. Increasing evidence suggests that the calf pain experienced when walking followed by rest generates a low-grade inflammatory response. The cumulative effects of these individual events may have an adverse effect on the progression of atherosclerosis. A review of the literature was performed to identify studies measuring the exercise-induced inflammatory response in claudicants and to try to identify the role of cumulative inflammatory changes in the progression of atherosclerosis. The effect of exercise training on these markers is briefly explored. Walking until the onset of calf pain (ischaemia) followed by rest (reperfusion) results in the generation of oxygen-derived free radicals, neutrophil activation and a generalized increase in vascular permeability. Baseline levels of chronic inflammatory markers such as acute-phase proteins are elevated in claudicants compared with controls, suggesting that the transient acute inflammatory response has longer-term consequences. Therapeutic exercise training appears to lead to an attenuation of these inflammatory markers. Intermittent claudication can be considered as part of an inflammatory disease process. However, the concerns that exercise training might potentiate the vascular inflammatory response appear to be unjustified, although further work is needed to clarify this. Exercise training should therefore be considered as an important treatment option for claudication.

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Section: Assessment Of Vascular Endothelial Damage Following Ischaemimentioning

confidence: 65%

Section: Assessment Of Vascular Endothelial Damage Following Ischaemimentioning

confidence: 99%

Biochemical and inflammatory changes in the exercising claudicant

Tisi

Shearman

1998

Vasc Med

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“…For example, microalbuminuria is found in patients following positive exercise electrocardiogram tests, 18 and after exercise in patients with intermittent claudication. 19 In this latter group the degree of microalbuminuria is proportional to the severity of vascular disease and can be attenuated by surgical revascularisation. 20 What many studies of microalbuminuria and cardiovascular risk have failed to take into consideration is the exquisite sensitivity of albumin excretion to even mild inflammatory conditions.…”

Section: In This Issue Drs Reid Et Almentioning

confidence: 99%

Microalbuminuria and cardiovascular risk: a word of caution

Gosling

1998

J Hum Hypertens

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“…It has been found to be proportional to the size of the infarct and claudication pain. [15] [20] Hence, early recognition of microalbuminuria has beneficial influence on the management and outcome of these diseases.…”

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confidence: 99%

Relationship of Microalbuminuria With Acute Myocardial Infarction in Nondiabetic Normotensive Patients

Mishra¹,

Kumar²,

Dev³

et al. 2016

jebmh

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BACKGROUND Microalbuminuria (MAU) is defined as an urinary albumin excretion rate between 30-300 mg/day. It is a surrogate marker for endothelial dysfunction and is independently associated with atherosclerosis in diabetic and in nondiabetic patients. Microalbuminuria (MA) has important correlations with the development of CAD. It is increasingly being believed to be an emerging risk factor of this disease. AIMS AND OBJECTIVES Therefore, the present research was done; 1. To evaluate the prevalence of microalbuminuria in nondiabetic and non-hypertensive subjects who had an acute myocardial infarction. 2. Short-term outcomes and its prognostic importance as indicator of cardiovascular-related complications. 3. To evaluate the relationship between Microalbuminuria and Acute Myocardial Infarction in nondiabetic and nonhypertensive patients admitted in CCU of Cardiology Department, TMU, Moradabad. MATERIALS AND METHODS A cross-sectional and hospital-based study was performed. A total of 150 patients who were neither hypertensive nor diabetic and who had an acute myocardial infarction were included in this study. Microalbuminuria was determined by immunoturbidimetric method. Serum glucose and urea were measured by enzymatic method. Serum creatinine was measured by kinetic colorimetric method. RESULTS A significant Microalbuminuria was found in patients of AMI who were nondiabetic and non-hypertensive. The mortality in short-term outcome was also significantly increased in patients having MA, which highlights the significance of Microalbuminuria as an important prognostic biomarker. CONCLUSION Microalbuminuria has an important association with acute myocardial infarction in the absence of traditional risk factors like Hypertension and Diabetes.

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Assessment of intermittent claudication by quantitation of exercise induced microalbuminuria

Cited by 45 publications

References 11 publications

Biochemical and inflammatory changes in the exercising claudicant

Biochemical and inflammatory changes in the exercising claudicant

Microalbuminuria and cardiovascular risk: a word of caution

Relationship of Microalbuminuria With Acute Myocardial Infarction in Nondiabetic Normotensive Patients

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