Microalbuminuria and cardiovascular risk: a word of caution

Gosling, Peter

doi:10.1038/sj.jhh.1000594

Cited by 16 publications

(10 citation statements)

References 20 publications

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“…4 Gosling et al, also considered it to be an emerging cardiovascular risk indicator, though he felt more studies are required to come to a conclusion. 8 Our study agrees with these studies as it shows a significant microalbuminuria in the acute myocardial infarction patients and none of them were diabetic.…”

Section: Discussionsupporting

confidence: 82%

A study of predictive value of microalbuminuria in early outcome of non-diabetic patients of acute myocardial infarction

Patel¹,

Acharya

Saiyad

2017

Int J Adv Med

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Background: Excretion of albumin in urine, in the range of 30-300 mg/day is called microalbuminuria, which cannot be detected by routine urine tests. The presence of increased UAE (Urinary albumin excretion) signals an increase in the transcapillary escape rate of albumin and is therefore a marker of micro vascular disease. Thus, microalbuminuria is an early response to myocardial infarction.Methods: A prospective study of 50 patients of acute myocardial infarction was carried out to find out the sensitivity and the specificity of microalbuminuria in non-diabetic patients of acute STEMI; to verify the association between the level of microalbuminuria and the area of infarcts; and to establish the correlation of microalbuminuria with cardiac biomarkers.Results: Microalbuminuria test was positive in 92% patients in the study group and 20% subjects in the control group. The sensitivity of microalbuminuria in our study is 92% and the specificity is 80%. The level of Microalbuminuria does not statistically correlate with areas of myocardial infarction.Conclusions: Microalbuminuria is a non-specific yet highly sensitive marker of myocardial infarction and it can be used as an additional biochemical parameter in non-diabetic patients with acute myocardial infarction. Prognostic marker value of microalbuminuria appears unproved.

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Section: Discussionsupporting

confidence: 82%

A study of predictive value of microalbuminuria in early outcome of non-diabetic patients of acute myocardial infarction

Patel¹,

Acharya

Saiyad

2017

Int J Adv Med

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“…50 Taddei et al 51 found no difference in vascular response to acetylcholine between micro-and normoalbuminuria hypertensive subjects. Gosling 52 has recently pointed out that microalbuminuria is a very sensitive index of inflammation, reflecting vascular permeability, and that vascular disease is only one of a large number of inflammatory processes that can lead to microalbuminuria.…”

Section: Discussionmentioning

confidence: 99%

Silent ischemia is more prevalent among hypertensive patients with microalbuminuria and salt sensitivity

et al. 2003

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“…This led investigators during the early 1980s to search for early predictors of diabetic nephropathy through the measurement of low concentrations of albumin in the urine, especially in type 1 diabetic patients [10,11]. Despite a great deal of controversy [4,12], microalbuminuria is now widely accepted as a predictive marker of overt proteinuria [13] and increased cardiovascular disease and mortality [14] not only in type 1 diabetes mellitus [15], but also in type 2 diabetic mellitus [13]. The importance of albuminuria has increased in practice as well as in laboratory research.…”

Section: Introductionmentioning

confidence: 99%

Serum Cystatin C Reflects the Progress of Albuminuria

Yoo

Lee

et al. 2011

Diabetes Metab J

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BackgroundResearch on the relationship between urinary albumin excretion and serum cystatin C in diabetes is restricted to cross-sectional studies. In this study, we investigated how well serial measurements of serum cystatin C level reflect changes in the urinary albumin excretion rate.MethodsWe enrolled and retrospectively collected data on 1,058 participants with type 2 diabetes who were older than 18 years and who had more than 3 years of follow-up with serial measurements of albuminuria and serum cystatin C at an outpatient clinic.ResultsWith the use of a linear mixed model, we found that the albuminuria level for each patient over time corresponded with the annual change in serum cystatin C-based estimated glomerular filtration rate (cysC-eGFR) but did not correspond with the creatinine-based eGFR calculated by the modification of diet in renal disease formula (MDRD-eGFR). The discrepancy in the direction of the trend was smaller with cysC-eGFR than with MDRD-eGFR.ConclusionSerum cystatin C level reflects the trend in albuminuria level more accurately than serum creatinine level in Korean type 2 diabetes mellitus patients.

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Microalbuminuria and cardiovascular risk: a word of caution

Cited by 16 publications

References 20 publications

A study of predictive value of microalbuminuria in early outcome of non-diabetic patients of acute myocardial infarction

A study of predictive value of microalbuminuria in early outcome of non-diabetic patients of acute myocardial infarction

Silent ischemia is more prevalent among hypertensive patients with microalbuminuria and salt sensitivity

Serum Cystatin C Reflects the Progress of Albuminuria

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