Relationship of Microalbuminuria With Acute Myocardial Infarction in Nondiabetic Normotensive Patients

Abstract

BACKGROUND Microalbuminuria (MAU) is defined as an urinary albumin excretion rate between 30-300 mg/day. It is a surrogate marker for endothelial dysfunction and is independently associated with atherosclerosis in diabetic and in nondiabetic patients. Microalbuminuria (MA) has important correlations with the development of CAD. It is increasingly being believed to be an emerging risk factor of this disease. AIMS AND OBJECTIVES Therefore, the present research was done; 1. To evaluate the prevalence of microalbuminuria in nondiabetic and non-hypertensive subjects who had an acute myocardial infarction. 2. Short-term outcomes and its prognostic importance as indicator of cardiovascular-related complications. 3. To evaluate the relationship between Microalbuminuria and Acute Myocardial Infarction in nondiabetic and nonhypertensive patients admitted in CCU of Cardiology Department, TMU, Moradabad. MATERIALS AND METHODS A cross-sectional and hospital-based study was performed. A total of 150 patients who were neither hypertensive nor diabetic and who had an acute myocardial infarction were included in this study. Microalbuminuria was determined by immunoturbidimetric method. Serum glucose and urea were measured by enzymatic method. Serum creatinine was measured by kinetic colorimetric method. RESULTS A significant Microalbuminuria was found in patients of AMI who were nondiabetic and non-hypertensive. The mortality in short-term outcome was also significantly increased in patients having MA, which highlights the significance of Microalbuminuria as an important prognostic biomarker. CONCLUSION Microalbuminuria has an important association with acute myocardial infarction in the absence of traditional risk factors like Hypertension and Diabetes.