of n-3 fatty acids in patients with previous myocardial infarction or heart failure. The authors suggest primary benefit of n-3 fatty acids is antiarrhythmic in patients, such as those with previous myocardial infarction or heart failure, who are perhaps more prone to ventricular arrhythmic events.

INTRODUCTIONVDD is now a pandemic cutting across age groups, ruralurban divide and developing or developed countries. . Vit-D level <20ng/ml i.e. Vit-D deficiency (VDD) in 68, 20-30ng/ml i.e. Vit-D insufficiency (VDI) in 22 and >30ng/ml (normal) in 10. VDD was profound in 51-60 and 61-70 years age groups. Statistical correlation of VDD was not significant with conventional risk factors, but statistically significant correlation of VDD was observed with dyslipidemia and CAG findings in our study. Conclusions: Like earlier studies we observed significant correlation of Vit-D levels with CAD. Though dyslipidemia was significantly correlated with VDD, correlation of other conventional risk factors like age, sex, HTN, DM, smoking and family history was not found. We conclude from this study presence of significant association of VDD with severe CAD. DVD and TVD by CAG were common with low Vit-D levels.

BACKGROUND Microalbuminuria (MAU) is defined as an urinary albumin excretion rate between 30-300 mg/day. It is a surrogate marker for endothelial dysfunction and is independently associated with atherosclerosis in diabetic and in nondiabetic patients. Microalbuminuria (MA) has important correlations with the development of CAD. It is increasingly being believed to be an emerging risk factor of this disease. AIMS AND OBJECTIVES Therefore, the present research was done; 1. To evaluate the prevalence of microalbuminuria in nondiabetic and non-hypertensive subjects who had an acute myocardial infarction. 2. Short-term outcomes and its prognostic importance as indicator of cardiovascular-related complications. 3. To evaluate the relationship between Microalbuminuria and Acute Myocardial Infarction in nondiabetic and nonhypertensive patients admitted in CCU of Cardiology Department, TMU, Moradabad. MATERIALS AND METHODS A cross-sectional and hospital-based study was performed. A total of 150 patients who were neither hypertensive nor diabetic and who had an acute myocardial infarction were included in this study. Microalbuminuria was determined by immunoturbidimetric method. Serum glucose and urea were measured by enzymatic method. Serum creatinine was measured by kinetic colorimetric method. RESULTS A significant Microalbuminuria was found in patients of AMI who were nondiabetic and non-hypertensive. The mortality in short-term outcome was also significantly increased in patients having MA, which highlights the significance of Microalbuminuria as an important prognostic biomarker. CONCLUSION Microalbuminuria has an important association with acute myocardial infarction in the absence of traditional risk factors like Hypertension and Diabetes.

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BACKGROUNDBeta-blocker is considered to be a very effective antihypertensive drug to control hypertension. But National Institute for Health and Clinical Excellence (NICE) recommended that it should no longer be used as first-line drug as the treatment of uncomplicated hypertension. This recommendation was based on the various studies showing increased risk of new onset Diabetes Mellitus and derangement of lipid metabolism with the use of beta-blocker. These studies were mainly based on Atenolol with or without diuretics. We are in need of a beta-blocker that has effective antihypertensive properties without altering the metabolic profile like blood sugar level and lipid metabolism. Nebivolol, a b1-selective blocker, has got more or less the similar properties. It increases insulin sensitivity in patients with insulin resistance due to its vasodilator properties. Also, antioxidant properties of nebivolol, and increase in nitric oxide properties by reducing its oxidative inactivation may be responsible for beneficial lipid and carbohydrate metabolic profile.