Assessment of Interleukin-17 System in Children With Allergic Bronchial Asthma

Просекова, Е. В.; Turyanskaya, A I; Сабыныч, В. А.

doi:10.17238/pmj1609-1175.2018.4.37-40

Cited by 3 publications

(1 citation statement)

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“…In the same period, duration of exacerbations decreased by 2.2-2.5 times, frequency of hospitalizations decreased by 2.0-2.5 times, duration of hospitalizations decreased by 2.3-3 times, and the need for outpatient care decreased by 1.6 timesin asthma patients and 20% (p >0.05) in the COPD patients. The obtained results are consistent with the data of other researchers who studied the vaccine efficacy against influenza in patients with bronchopulmonary pathology [41][42][43].…”

Section: Discussionsupporting

confidence: 92%

Vaccination against Influenza: Clinical and Cytokine Profile of Patients with Asthma and Chronic Obstructive Pulmonary Disease

Kostinov,

Chuchalin,

Chebykina

et al. 2023

Preprint

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Background: Influenza vaccine is a tool for preventing infection and reducing exacerbations in patients with asthma and chronic obstructive pulmonary disease (COPD). Purpose of this study is to investigate dynamics of CRP and serum cytokines (IL-2, IL-6, IL-10, IL-17) in patients with asthma and COPD, as well as to perform a correlation analysis with the clinical parameters of the disease manifestation. Methods: The study included 34 patients with asthma, 20 patients with COPD vaccinated against influenza during a period of remission from 2 to 4 weeks, both groups being under a basic maintenance therapy, and 26 healthy individuals vaccinated with the trivalent polymer-subunit vaccine Grippol® Plus, containing 5 µg of influenza virus strains and 500 µg of azoximer bromide. Results: Observing patients with asthma and COPD, during a year after the vaccination, has revealed a significant reduction in exacerbations frequency (p < 0.05) and duration (p < 0.05) of the bronchial obstructive syndrome (BF). Before the vaccination the IL-6 level in patients with asthma had a direct moderate correlation with duration of exacerbations of the underlying disease (p < 0.05), along with the number of systemic corticosteroids courses during exacerbations (p < 0.05). In 12 months after the vaccination, while assessing cytokine profile of all study groups, a significant reduction in the level of IL-6 was observed, compared to the baseline values (p< 0.05). Conclusion: Conducted analysis of immunological, clinical, and functional parameters of patients with asthma and COPD has proven for influenza vaccine to be effective in BF patients.

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Section: Discussionsupporting

confidence: 92%

Vaccination against Influenza: Clinical and Cytokine Profile of Patients with Asthma and Chronic Obstructive Pulmonary Disease

Kostinov,

Chuchalin,

Chebykina

et al. 2023

Preprint

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Study of the production of some cytokines in viral infections occurring with diarrheal syndrome in children

et al. 2020

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The aim of the study was to study the characteristics of the content of certain cytokines in serum as indicators of the immune response in viral infections accompanied by diarrhea syndrome in children. Materials and research methods. A survey was conducted of 92 children aged 3 months to 15 years with acute respiratory viral infections hospitalized in hospital No. 6 in Novosibirsk in the first 2 days from the onset of the disease. Two groups were formed — group 1 — patients with diarrheal syndrome and signs of respiratory system damage. Group 2 — children with isolated lesions of the respiratory tract. In all children, the genetic material of viruses was determined by polymerase chain reaction (PCR) in the nose and throat washes. Also, in all children, the determination of serum levels of IL-8, IL-17, IFN-ã by ELISA was performed. Results and discussion. When studying the levels of cytokines (IFN-ã, IL-8, IL-17) in patients with signs of gastrointestinal tract lesions in comparison with isolated respiratory manifestations, no statistically significant differences were found. However, when analyzing the levels of the studied parameters in patients with diarrheal syndrome in different age groups, significant differences in the levels of IFN-ã and IL-8 were revealed.

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The effect of antihistamines drugs on the functional activity of neutrophils

Плехова

Dubnyak²,

Елисеева

2021

Genes & Cells

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Allergic inflammation is accompanied by stimulation of neutrophils with an increase in the formation of reactive oxygen species. The antioxidant effectiveness of some antihistamines is known, which reduces the risk of damage to surrounding tissues with the participation of these cells. Objective of the study: to determine the degree of various generations antihistamines influence on the death and enzymatic activity of neutrophils. The effect of the first antihistamines (diphenhydramine, clemastine) and second (lorata-dine, desloratadine) generations and the hormonal drug dexameth-asone on cell viability, the formation of active oxygen metabolites, enzyme activity, the amount of cationic proteins, and cytokine production by neutrophils was studied using the in vitro model. It was found that after exposure to loratadine at a dose of 2.5 |jg / ml, the number of viable cells was comparable (p = 0.001) with that in an intact culture. Found a stimulating effect of second generation antihistamines (loratadine, desloratadine) in low doses on the activity of NADPH-dependent oxide reductase. The form of neutrophil death depended on the type and dose of the drug; apoptosis was predominantly observed after cell contact with loratadine and desloratadine. Against the background of an increase in the activity of ATPase and myeloperoxidase after contact with diphenhydramine and clemastine (2.5 jg / ml), the largest number of neutrophils producing reactive oxygen species was revealed. Under the influence of desloratodine and clemastine, exocytosis of cationic proteins into the extracellular space and the lowest production of cytokines after contact with the latter were established. Thus, exposure to Hl-antihistamines, active both extra- and intracellular (diphenhydramine, loratadine), probably disrupted the metabolism of neutrophils, which led to an increase in their killer potential. Clemastine, acting mainly extracellularly, minimized the toxic effects of extracellular radicals, without affecting the production of intracellular oxidants involved in the regulation of neutrophil functions.

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Assessment of Interleukin-17 System in Children With Allergic Bronchial Asthma

Cited by 3 publications

References 0 publications

Vaccination against Influenza: Clinical and Cytokine Profile of Patients with Asthma and Chronic Obstructive Pulmonary Disease

Vaccination against Influenza: Clinical and Cytokine Profile of Patients with Asthma and Chronic Obstructive Pulmonary Disease

Study of the production of some cytokines in viral infections occurring with diarrheal syndrome in children

The effect of antihistamines drugs on the functional activity of neutrophils

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