Assessment of Hematological and Inflammatory Parameters in Patients Receiving Isotretinoin Therapy for Acne Vulgaris

Yaldız, Mahizer; Çetinkaya, Reyhan; Solak, Berna

doi:10.17944/mkutfd.421437

Cited by 4 publications

(1 citation statement)

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“…Moreover, Yaldız et al [18] examined the hematological and inflammatory changes associated with the treatment of acne vulgaris with systemic isotretinoin. Their study involving 352 patients demonstrated a significant reduction in inflammatory markers in terms of leukocytes and neutrophils; however, there was a significant increase in platelet count during the treatment course.…”

Section: Discussionmentioning

confidence: 99%

Isotretinoin-Induced Thrombocytosis in a Patient With Acne Vulgaris: A Case Report

Al-Yasi¹,

Hawsawi²,

Malebari³

et al. 2021

Cureus

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Isotretinoin is one of the first-line medications for the treatment of acne. One of the reported side effects of isotretinoin is thrombocytopenia, in addition to other abnormalities such as incomplete blood count. However, reports on thrombocytosis associated with isotretinoin are controversial. The present report discusses the case of a patient with acne vulgaris who was treated with isotretinoin and consequently suffered from isotretinoin-induced thrombocytosis.A 20-year-old female patient was diagnosed with acne vulgaris and started treatment with systemic isotretinoin (20 mg once daily) for one month. A baseline complete blood count was performed, as well as another blood count after one month of medication administration. Platelet count was recorded at each visit. The baseline platelet count was within the normal range; however, it was found to be elevated after one month of treatment. Accordingly, the medication was discontinued, and the platelet count returned to normal levels after one month, as measured during the monthly visit. The patient also experienced seizure episodes during treatment, which did not cease with the treatment discontinuation. Although isotretinoininduced thrombocytosis is considered a rare side-effect for isotretinoin, it should be routinely monitored in high-risk patients and those undergoing surgeries. Further prospective studies on isotretinoin-induced thrombocytosis need to be conducted to gain a deeper insight into the various aspects related to the condition.

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Section: Discussionmentioning

confidence: 99%