Investigation of systemic immune-inflammation index and systemic inflammation response index as an indicator of the anti-inflammatuary effect of isotretinoin in patients with acne vulgaris

Coşansu, Nur Cihan; Yuksekal, Gülcan; Turan, Ulku; Umitfer, Fulya; Yaldız, Mahizer; Dikicier, Bahar Sevimli

doi:10.1080/15569527.2022.2081700

Cited by 11 publications

(6 citation statements)

References 26 publications

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“…When the treatment in advance hemogram parameters of the patients and the values in the third month were compared, no statistically significant differences were detected in the lymphocyte count, monocyte count, platelet-to-lymphocyte ratio, and monocyte–lymphocyte ratio. 73 Inflammatory and non-inflammatory lesions were significantly reduced after 3 months of oral ISO at a dose of 0.5–0.7 mg/kg/day. 13 Besides, when other parameters were evaluated, total white blood cell counts, neutrophils, lymphocytes, monocytes, basophils, and platelets did not change from baseline, however, there was a significant decrease in mean GAGS score, total, inflammatory and non-inflammatory lesion counts, eosinophils, and absolute eosinophil count.…”

Section: Resultsmentioning

confidence: 94%

“…Zane et al 72 found that ISO use could cause leukopenia, neutropenia, agranulocytosis, thrombocytopenia, thrombocytosis, and other abnormalities in hematological parameters. Cosansu et al 73 found that low-density lipoprotein cholesterol, serum total cholesterol, aspartate aminotransferase levels, and triglyceride increased after ISO treatment. When the treatment in advance hemogram parameters of the patients and the values in the third month were compared, no statistically significant differences were detected in the lymphocyte count, monocyte count, platelet-to-lymphocyte ratio, and monocyte–lymphocyte ratio.…”

Section: Resultsmentioning

confidence: 99%

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Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review

Ding¹,

Zheng²,

Jin³

2023

CCID

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Isotretinoin (ISO) is a powerful vitamin A derivative that offers the potential for treatment of permanent remission of acne; however, its potential side effects on both physiological and psychological aspects limit its application. This article reviews the side effects of ISO from physiological and psychological aspects in detail, to better screen the suitable population of ISO and improve the efficiency of clinical treatment. Our findings indicate that ISO may cause teratogenicity, skin reactions, ocular reactions, changes in blood indicators, and occasional acne fulminans. To optimize clinical treatment, more attention should be paid to identifying the specific conditions under which these reactions occur, how severe they are, and how they subside to alleviate patient concerns. Regarding the controversial issue of psychological side effects caused by ISO, researchers should shift their focus to the psychological problems that acne itself may cause.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review

Ding¹,

Zheng²,

Jin³

2023

CCID

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“…Currently, the use of SIRI and SII in clinical prognosis remains limited. A few studies have shown that SIRI and SII can reliably predict the efficacy of anti-inflammatory therapies in treating specific inflammation-related disorders such as chronic spontaneous urticaria and acne vulgaris [ 71 , 72 ]. However, broader investigations are necessary to validate the potential roles of these novel inflammatory markers in the prognosis of conditions like obesity and CVD.…”

Section: Discussionmentioning

confidence: 99%

System inflammation response index: a novel inflammatory indicator to predict all-cause and cardiovascular disease mortality in the obese population

Kong,

Huang,

et al. 2023

Diabetol Metab Syndr

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Aim This study aims to investigate the relationship between two novel inflammatory markers, namely, the Systemic Inflammatory Response Index (SIRI) and the Systemic Immune Inflammatory Index (SII), as well as the all-cause and cardiovascular disease (CVD) mortality in the obese population. Materials and methods We conducted a prospective cohort study based on the data of 13,026 obese adults (age ≥ 18 years) from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014 and followed until December 2019. SIRI was calculated by the formula: (neutrophil count × monocyte count) / lymphocyte count, while that of SII was: (platelet count × neutrophil count)/lymphocyte count. The association of SIRI and SII with all-cause and CVD mortality was evaluated using Cox regression. In addition, the nomogram was performed to predict 10-year survival probability. Results During a median follow-up of 137 months, 1959 and 553 all-cause and CVD deaths were recorded, respectively. Spearman correlation analysis indicated that SIRI and SII were unrelated to almost all baseline characteristics (r < 0.15). Multivariate Cox regression models displayed that each standard deviation (SD) increase in SIRI was associated with a 16% (HR 1.16; 95% CI 1.09–1.24) and 22% (HR 1.22; 95% CI 1.10–1.36) increase in the risk of all-cause and CVD mortality, respectively. Likewise, every SD increase in SII was correlated with a 9% (HR 1.09; 95% CI 1.02–1.16) and 14% (HR 1.14; 95% CI 1.04–1.26) increase in the risk of all-cause and CVD mortality, respectively. The predictive value of SIRI for all-cause and CVD mortality (AUC = 0.601 and 0.624) exceeded that of SII (AUC = 0.528 and 0.539). Moreover, the nomogram displayed a substantial predictive value for 10-year survival (AUC = 0.847) with sensitivity and specificity exceeding 75%. Conclusions In the obese population, SIRI and SII are independent risk factors for all-cause and CVD mortality. Notably, the predictive ability of SIRI for both all-cause and CVD mortality significantly outperforms that of SII, suggesting that SIRI is a more valuable marker of inflammation.

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“…The study carried out by Cağri Turan et al 23 investigated the differences in some inflammatory markers in patients with acne vulgaris after oral isotretinoin treatment compared with healthy controls and themselves, and found that NLR did not substantively differ from controls before and after treatment, while SII can be used as the indicator of anti‐inflammatory effect of isotretinoin. Nur Cihan Cosansu et al 24 assessed the effectiveness of SII, systemic inflammatory response index (SIRI), and other inflammatory markers in patients with acne vulgaris treated with isotretinoin, and indicated that SII and SIRI were superior in being anti‐inflammatory indicators for the effects of isotretinoin. Similar experiments have been done by Omer Kutlu et al 25 on the effect of ISO treatment on MHR and other inflammatory markers in patients with acne vulgaris.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hematological parameters in patients with acnes

Chen

Shao

et al. 2023

J of Cosmetic Dermatology

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Investigation of systemic immune-inflammation index and systemic inflammation response index as an indicator of the anti-inflammatuary effect of isotretinoin in patients with acne vulgaris

Cited by 11 publications

References 26 publications

Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review

Physiological and Psychological Effects of Isotretinoin in the Treatment of Patients with Acne: A Narrative Review

System inflammation response index: a novel inflammatory indicator to predict all-cause and cardiovascular disease mortality in the obese population

Hematological parameters in patients with acnes

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