Assessment of Dietary Supplementation in the Treatment of Vitiligo

Smith, M. K.; Mohammad, Tasneem F.; Hamzavi, Iltefat

doi:10.2174/1874372201711010012

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…An increase in the number of circulating CD8+ lymphocytes that are reactive to Melan-A/Mart-1 (a melanoma antigen recognized by T cells), glycoprotein 100 (gp100), and tyrosinase. Activated CD8+ cells can be found in the skin around vitiligo lesions [25,26].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of adjuvant therapy gingko biloba extract on vitiligo treated by topical desoximetasone to melanin index and vasi score

Mulianto

Kariosentono

Purwanto

et al. 2022

ijhs

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Ginkgo biloba (GB) has anxiolytic properties, which can help to prevent the spread of vitiligo lesions. The purpose of this study was to examine the efficacy of adding orally and placebo GB extract as adjuvant therapy in treating depigmented lesions in vitiligo patients. This research is an experimental study with samples of vitiligo patients at the Dermatology and Venereology Polyclinic, RSUD Dr. Moewardi, Surakarta, Central Java, Indonesia. This study involved 23 patients aged 18-60 years. The sample met the inclusion criteria: routine control patients with stable non-segmental vitiligo with less than 20% lesions and not receiving therapy for the past four weeks. Research subjects were divided into two groups using a capsule containing 60 mg of GB extract and a placebo. The data were processed by statistical analysis using the SPSS and the Mann-Whitney test with a significance P-value <0.05. The results showed that the administration of GB was able to significantly reduce the melanin index in vitiligo patients at week 12 (p = 0.003 < 0.05).

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Section: Discussionmentioning

confidence: 99%

Efficacy of adjuvant therapy gingko biloba extract on vitiligo treated by topical desoximetasone to melanin index and vasi score

Mulianto

Kariosentono

Purwanto

et al. 2022

ijhs

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“…It has been suggested that melanocytes degeneration and lower melanin biosynthesis in vitiligo patients may result in increased serum Cu and Zn levels. Hence, the high serum levels of these elements in vitiligo are the result of the disease rather than its underlying cause [25]. Several other studies have reported significantly decreased serum levels of Cu and/or Zn among vitiligo patients [21,[26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Serum Copper and Zinc levels among Iranian vitiligo patients

Khoshdel

Gholijani

Niknam

et al. 2022

Dermatol Pract Concept

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Introduction: Vitiligo is a chronic skin disease, which its etiopathogenesis is not fully understood. Numerous studies have suggested that oxidative stress may play a role in the pathophysiology of vitiligo. There are controversial reports as to the changes of serum trace elements, copper and zinc levels in vitiligo patients. Objective: In this study, we evaluated the alterations in the level of serum Cu and Zn among a group of Iranian vitiligo patients. Methods: The levels of serum Cu and Zn were compared between 117 vitiligo patients and 137 healthy controls using atomic absorption spectrophotometry. Results: The mean Cu and Zn levels in the case group (113.57 ± 59.43 and 95.01 ± 58.95 μg/dl, respectively) were significantly lower than those of the control group (138.90 ± 38.14 and 121.83 ± 33.80 μg/dl, respectively) (p= 0.00). We also observed significantly lower serum Cu and Zn concentrations in young (<50 years) than the elderly (≥50 years) patients (p=0.00). The mean Cu and Zn levels in the patients with generalized vitiligo (111.63±54.18 and 93.11±59.33 μg/dl, respectively) were significantly lower than patients with localized vitiligo (120.74 ±71.64 and 98.69±58.63 μg/dl, respectively) and those in the control group (p = 0.00). The serum Cu/Zn ratio obtained in the young and male patients was higher than those in their matched control counterparts (p=0.01). Conclusions: The current study has shown that the disturbance of serum Cu and Zn levels is associated with vitiligo, and may play an important role in the disease development of Iranian vitiligo patients.

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“…However, more than 90% of vitamin D which is powerful antioxidant is formed after the body is exposed to sunlight. [14,15]. In vitiligo, Rathore et al [16] revealed substantial improvement in CAT and SOD activity after oral antioxidants and NB-UVB phototherapy.…”

Section: Introductionmentioning

confidence: 99%

Estimation of serum levels of vitamin D, Calcium, Phosphorous, matrix metalloproteinases 1, 2, and tissue inhibitor matrix metalloproteinase -1 in patients with acrofacial vitiligo during COVID-19

Youness¹,

Hussein

Aly

et al. 2021

Egypt. J. Chem.

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Vitiligo is the loss of functional melanocytes from epidermis. Acrofacial type occurs when depigmentation affects parts apart from the body centers as face, head, hands and feet. Vitamin D may have a role in both acrofacial vitiligo and Covid 19. The present study designed to investigate the role of serum levels of vitamin D, Calcium (Ca), phosphorous (Ph), matrix metalloproteinases 1 and 2 (MMPs 1, 2) and tissue inhibitor matrix metalloproteinase -1 (TIMP1) in acrofacial vitiligo during Covid-19. Activity of MMP1, MMP2 and TIMP1 calcium and phosphorous levels were measured in serum. 40 control subjects and 40 patients' suffering acrofacial vitiligo, whose ages ranged from 17-36 years with matching sex and skin phototype all were examined. Vitamin D and Ca levels showed significant decline in their levels in acrofacial vitiligo patients when compared to controls. Additionally, TIMP1 and MMP2 levels displayed significant decrease compared to control subjects, while elevation in MMP1 level was recognized. However, Phosphorous showed no significant difference between controls and cases. No significant alteration between patients and control in terms of sex & age was detected in the present study. We concluded that the selected measured parameters were suggested to participate in controlling and regulating the processes of melanocyte activity and migration in acrofacial vitiligo. These parameters were correlated to each other, since significant reduction in vitamin D & Ca was associated with the decrease in MMP2 and TIMP1 as well as significant increase in MMP1 in vitiligo patients. However, no significant differences were noticed in phosphorous levels in acrofacial vitiligo when compared to control subjects. Significant reduction in vitamin D was also correlated to Covid-19.

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Assessment of Dietary Supplementation in the Treatment of Vitiligo

Cited by 3 publications

References 38 publications

Efficacy of adjuvant therapy gingko biloba extract on vitiligo treated by topical desoximetasone to melanin index and vasi score

Efficacy of adjuvant therapy gingko biloba extract on vitiligo treated by topical desoximetasone to melanin index and vasi score

Serum Copper and Zinc levels among Iranian vitiligo patients

Estimation of serum levels of vitamin D, Calcium, Phosphorous, matrix metalloproteinases 1, 2, and tissue inhibitor matrix metalloproteinase -1 in patients with acrofacial vitiligo during COVID-19

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