Efficacy of adjuvant therapy gingko biloba extract on vitiligo treated by topical desoximetasone to melanin index and vasi score

Abstract

Ginkgo biloba (GB) has anxiolytic properties, which can help to prevent the spread of vitiligo lesions. The purpose of this study was to examine the efficacy of adding orally and placebo GB extract as adjuvant therapy in treating depigmented lesions in vitiligo patients. This research is an experimental study with samples of vitiligo patients at the Dermatology and Venereology Polyclinic, RSUD Dr. Moewardi, Surakarta, Central Java, Indonesia. This study involved 23 patients aged 18-60 years. The sample met the inclusion criteria: routine control patients with stable non-segmental vitiligo with less than 20% lesions and not receiving therapy for the past four weeks. Research subjects were divided into two groups using a capsule containing 60 mg of GB extract and a placebo. The data were processed by statistical analysis using the SPSS and the Mann-Whitney test with a significance P-value <0.05. The results showed that the administration of GB was able to significantly reduce the melanin index in vitiligo patients at week 12 (p = 0.003 < 0.05).