Assessment of a novel activity of Acacia nilotica leaf extract for chondrogenesis induction of Mesenchymal stem cells for dental applications

Fadhil, Yasir B.; Jaber, Mohammed Hadi; Ahmed, H.

doi:10.1016/j.phyplu.2021.100087

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Similarly, pre-treatment with resveratrol with SCAPs resulted in the induction of neural progenitor marker gene expression, ultimately enhancing the induction of neural progenitor-like cells via a synergistic mechanism when provided with a suitable neuronal induction medium [ 228 ]. The aqueous leaves extract of Acacia nilotica promoted chondrogenesis induction in DPSCs by upregulating the expression of various proteins in the cellular matrix, such as aggrecan, sox9, glycosaminoglycan (GAG), and collagen 2α1 (Col2α1) that are crucial for the formation of cartilage tissue [ 231 ].…”

Section: Botanicals In Oral Stem Cell-mediated Regenerationmentioning

confidence: 99%

Botanicals and Oral Stem Cell Mediated Regeneration: A Paradigm Shift from Artificial to Biological Replacement

Ahuja

Tyagi

Kumar

et al. 2022

Cells

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Stem cells are a well-known autologous pluripotent cell source, having excellent potential to develop into specialized cells, such as brain, skin, and bone marrow cells. The oral cavity is reported to be a rich source of multiple types of oral stem cells, including the dental pulp, mucosal soft tissues, periodontal ligament, and apical papilla. Oral stem cells were useful for both the regeneration of soft tissue components in the dental pulp and mineralized structure regeneration, such as bone or dentin, and can be a viable substitute for traditionally used bone marrow stem cells. In recent years, several studies have reported that plant extracts or compounds promoted the proliferation, differentiation, and survival of different oral stem cells. This review is carried out by following the PRISMA guidelines and focusing mainly on the effects of bioactive compounds on oral stem cell-mediated dental, bone, and neural regeneration. It is observed that in recent years studies were mainly focused on the utilization of oral stem cell-mediated regeneration of bone or dental mesenchymal cells, however, the utility of bioactive compounds on oral stem cell-mediated regeneration requires additional assessment beyond in vitro and in vivo studies, and requires more randomized clinical trials and case studies.

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Section: Botanicals In Oral Stem Cell-mediated Regenerationmentioning

confidence: 99%

Botanicals and Oral Stem Cell Mediated Regeneration: A Paradigm Shift from Artificial to Biological Replacement

Ahuja

Tyagi

Kumar

et al. 2022

Cells

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“…The decoction acquired from the bark is applied in mitigating sore throat complaints. Also, the bark is extensively employed as a mouth cleaner in commercially available toothpaste (Fadhil et al, 2021). Previously, scrutinized pharmacological outcomes had authenticated anti-inflammatory, antimicrobial, antidiuretic and antipyretic traits in the various organs of this tree (Ali, 2012;Roozbeh et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antifungal and Cytotoxic Impact of Acacia nilotica Bark Aqueous Extract

Janani¹,

Anbumani²,

Vizhi³

et al. 2022

IJZI

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The medicative plants were copiously applied in the healing of health complications. Traditionally implemented, medicative-worthy Acacia nilotica (Fabaceae family), is applied globe-wide in customary healing practices. Here, we have tried to unravel the antioxidant, fungicidal, antibacterial and cytotoxic trait of A. nilotica bark aqueous extract. Phyto-content testing revealed presence of flavonoids, tannins, alkaloids, phenols, carbohydrates, proteins, and amino acids. The antioxidant efficacies were 39.12 µg/ml (for DPPH assay) and 42.64 µg/ml (for NO assay) as IC50 ranges, respectively. The bark aqueous extract manifested fungicidal impact on all the screened fungal strains with the highest inhibitory zone against A. fumigatus (19.5 ± 0.45 mm). The MTT assay of bark aqueous extract registered a dose-related cytotoxic impression with 39.05 µg/ml (IC50 outcome). Hence, it emphasizes strongly that A. nilotica bark aqueous extract is a prospective therapeutic source and it is indispensable to further scrutinize its therapeutic and curative properties.

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Biological evaluation of Acacia nilotica (L.) Willd. ex Delile: a systematic review

Abdulrahman

Hama

Özdemir

2023

ADV TRADIT MED (ADTM)

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Assessment of a novel activity of Acacia nilotica leaf extract for chondrogenesis induction of Mesenchymal stem cells for dental applications

Cited by 3 publications

References 15 publications

Botanicals and Oral Stem Cell Mediated Regeneration: A Paradigm Shift from Artificial to Biological Replacement

Botanicals and Oral Stem Cell Mediated Regeneration: A Paradigm Shift from Artificial to Biological Replacement

Antioxidant, Antifungal and Cytotoxic Impact of Acacia nilotica Bark Aqueous Extract

Biological evaluation of Acacia nilotica (L.) Willd. ex Delile: a systematic review

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