Aspects of Ascorbic Acid Biosynthesis in Animals*

Chatterjee, I. B.; Kar, Nirmal C.; Ghosh, Nilabja; Guha, B. C.

doi:10.1111/j.1749-6632.1961.tb46105.x

Cited by 97 publications

(33 citation statements)

References 17 publications

(3 reference statements)

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“…The animals which must synthesize vitamin C do so from glucose via gulonic acid (3,5 to expect animals with a greater supply of substrate to exhibit a greater capacity to synthesize ascorbic acid, which in turn would be reflected in the blood levels.…”

Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Metabolism in Swine. Interrelationships Between the Level of Energy Intake and Serum Ascorbate Levels

Brown¹,

Sharma²,

Young³

1970

Can. J. Anim. Sci.

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The influence of energy intake on serum the serum increased significantly with time in ascorbate levels in swine has been studied. animals fed higher levels of energy, but Dot in There was a significant correlation between animals which recoived lower levels of energy. energy intake and serum ascorbate levels at Th's suggested that energy restriction inage 85-95 days, as well as a significant cor-hibited the development of the capacity to relation between terminal weights and serum synthesize ascorbate. A hypothesis was adascorbate level. The level of ascorbic acid in vanced to explain the findings.

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Section: Discussionmentioning

confidence: 99%

Ascorbic Acid Metabolism in Swine. Interrelationships Between the Level of Energy Intake and Serum Ascorbate Levels

Brown¹,

Sharma²,

Young³

1970

Can. J. Anim. Sci.

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“…However, the rat is not a suitable animal model for the investigation of effects which may occur in man under the influence of a toxic substance, particularly if these effects are mediated through oxido-redox alterations of the relevant enzymes. Ascorbic acid (a "vitamin" for man but not for rat), an important redox catalyzer, is a good example of this situation (3). The other example is glutathione.…”

Section: Discussionmentioning

confidence: 99%

In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man.

Prpı́c-Majı́c¹,

Telišman²,

Kežić³

1984

Scand J Work Environ Health

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In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man. by Prpic-Majic D, Telisman S, Kezic S This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/6494843 Scand J Work Environ Health 10 (1984) [235][236][237][238] In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man1by Danica PrpiC-Majid, PhD, Spomenka eli ism an, DSc, Sanja ~e i i C , MSc2PRPIC-MAJIC D, TELI~MAN S, K E~I C S. In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man. Scand J Work Environ Health 10 (1984) 235-238. The effect of lead (Pb) and ethanol (EtOH) interaction on the inhibition of erythrocyte 6-aminolevulinic acid dehydratase (ALAD) was investigated in human blood in vitro. Two different doses of ethanol (equivalent to 16.28 mmol of EtOH/l of blood and 108.53 mmol of EtOH/l of blood) and lead (equivalent to 2.17 pmol of Pb/l of blood and 4.34 pmol of Pb/l of blood) were examined separately and in combination. The dose-effect (EtOH-ALAD) relationship for a wide range of ethanol concentrations (0-217.06 mmol of EtOH/l of blood) was also investigated. The results obtained indicate that ethanol by itself does not inhibit ALAD, while lead does it readily. Neither ethanol concentrations signifi-' cantly altered ALAD activity. The dose-effect (EtOH-ALAD) relationship did not reveal any inhibitory effect of ethanol on ALAD either; however, a weak trend towards increased ALAD activity was found. The effect of ethanol combined with lead indicated no significant difference as compared to the effect of the same dose of lead per se; however, a weak trend towards decreased ALAD activity was found. These findings support the hypothesis that the effect of ethanol on the transient inhibition of ALAD activity in vivo does not occur directly, but possibly through the intermediary action of lead from the body lead pool.

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“…Rats were killed by decapitation and microsomes were prepared from the livers by the method of Chatterjee et al (1960a The experiments were performed in the presence of pyrophosphate, pH7-4 (20mm), since in its absence there is a diminished formation of L-ascorbic acid from L-gulonolactone by rat-liver microsomes (Chatterjee, Kar, Ghosh & Guha, 1961). Ascorbic acid and protein in the microsomal preparations were estimated as described by Chatterjee et al (1960a RESULTS Effects of hypervitaminosis A and hypervitaminosis D on the conversion of D-glucuronolactone and Lgulonolactone into L-ascorbic acid by rat-liver microsomes.…”

Section: Methodsmentioning

confidence: 99%

Effects of vitamins A and D on the biosynthesis of l-ascorbic acid by rat-liver microsomes

Ghosh

Chatterjee

1965

Biochemical Journal

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1. The synthesis of L-ascorbic acid from either D-glucuronolactone or L-gulonolactone by liver microsomes ofrats is decreased under conditions ofhypervitaminosis A; under hypervitaminosis D the synthesis from D-glucuronolactone is increased and that from L-gulonolactone is not affected. 2. The microsomal conversion of L-gulonolactone into L-ascorbic acid is impaired in liver tissues of rats made deficient with respect to either vitamin A or vitamin D when compared with the controls maintained on stock diet.

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Aspects of Ascorbic Acid Biosynthesis in Animals*

Cited by 97 publications

References 17 publications

Ascorbic Acid Metabolism in Swine. Interrelationships Between the Level of Energy Intake and Serum Ascorbate Levels

Ascorbic Acid Metabolism in Swine. Interrelationships Between the Level of Energy Intake and Serum Ascorbate Levels

In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man.

Effects of vitamins A and D on the biosynthesis of l-ascorbic acid by rat-liver microsomes

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