In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man.

Abstract

In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man. by Prpic-Majic D, Telisman S, Kezic S This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/6494843 Scand J Work Environ Health 10 (1984) [235][236][237][238] In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man1by Danica PrpiC-Majid, PhD, Spomenka eli ism an, DSc, Sanja ~e i i C , MSc2PRPIC-MAJIC D, TELI~MAN S, K E~I C S. In vitro study on lead and alcohol interaction and the inhibition of erythrocyte delta-aminolevulinic acid dehydratase in man. Scand J Work Environ Health 10 (1984) 235-238. The effect of lead (Pb) and ethanol (EtOH) interaction on the inhibition of erythrocyte 6-aminolevulinic acid dehydratase (ALAD) was investigated in human blood in vitro. Two different doses of ethanol (equivalent to 16.28 mmol of EtOH/l of blood and 108.53 mmol of EtOH/l of blood) and lead (equivalent to 2.17 pmol of Pb/l of blood and 4.34 pmol of Pb/l of blood) were examined separately and in combination. The dose-effect (EtOH-ALAD) relationship for a wide range of ethanol concentrations (0-217.06 mmol of EtOH/l of blood) was also investigated. The results obtained indicate that ethanol by itself does not inhibit ALAD, while lead does it readily. Neither ethanol concentrations signifi-' cantly altered ALAD activity. The dose-effect (EtOH-ALAD) relationship did not reveal any inhibitory effect of ethanol on ALAD either; however, a weak trend towards increased ALAD activity was found. The effect of ethanol combined with lead indicated no significant difference as compared to the effect of the same dose of lead per se; however, a weak trend towards decreased ALAD activity was found. These findings support the hypothesis that the effect of ethanol on the transient inhibition of ALAD activity in vivo does not occur directly, but possibly through the intermediary action of lead from the body lead pool.

Semen quality and reproductive endocrine function in relation to biomarkers of lead, cadmium, zinc, and copper in men.

“…Apart from numerous sources of occupational exposure to each of the metals, the most important nonoccupational sources are food (especially seafood from metal-polluted areas), water (Pb, mostly from Pb pipes in contact with soft and acidic water), air (especially Pb from gasoline in dense traffic areas), Pb-based paints of housing, smoking habits [Cd and (to a lesser extent) Pb from tobacco], and alcohol consumption (Pb-contaminated alcoholic beverages). There is also some evidence of the possible interaction of Pb and alcohol in humans, that is, an ethanolinduced increase in the biologically active or mobile fraction of Pb accumulated in the body (6)(7)(8).…”