Ascorbic Acid Metabolism in Swine. Interrelationships Between the Level of Energy Intake and Serum Ascorbate Levels

Brown, R. G.; Sharma, Vineet; Young, L. G.

doi:10.4141/cjas70-082

Cited by 11 publications

(7 citation statements)

References 4 publications

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“…The pigs in this study were exposed to a high environmental temperature due to problems with the ventilation during early spring, which may have contributed to the variations in the vitamin C plasma levels. It has also been suggested that the requirements of vitamin C synthesis are not met during the fast growth of the pigs, and that the level of plasma amino acid is affected by the amount of dietary energy (Brown et al., 1970, 1975; Dvorak, 1974). However, we did not find a significant association between the plasma vitamin C levels and growth rate.…”

Section: Discussionmentioning

confidence: 99%

Vitamin C Plasma Concentrations and Leg Weakness in the Forelegs of Growing Pigs

Armocida¹,

Beskow²,

Amcoff³

et al. 2001

Journal of Veterinary Medicine Series A

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Four litters (41 pigs) of cross-bred pigs were studied from 6 to 26 weeks of age. Blood samples were collected at 6, 13, 21 and 26 weeks of age and analysed for contents of vitamin C, calcium (Ca), inorganic phosphorus (P) and alkaline phosphatase (ALP). The pigs were examined clinically for foreleg weakness at the ages of 21 and 26 weeks. At the age of 26 weeks the pigs were slaughtered and the right forelegs were examined macroscopically and selected samples were collected for radiological, histological and ultrastructural examination. The prevalence of foreleg lesions was high, with lesions of dyschondroplasia of the distal growth plate of the ulna in 30 pigs, synovitis of the elbow joint in 24 pigs and osteochondritis dissecans of the elbow joint in 25 pigs. At the ages of 21 and 26 weeks, five pigs had evidently crooked forelegs and 14 pigs (age 21 weeks) and 25 pigs (age 26 weeks) had mildly deformed forelegs. The serum levels of Ca, P and ALP were within normal values for growing-finishing pigs. The range of vitamin C concentrations in plasma showed a wide difference (7.1-49.8 mumol/l) but was not associated with deformed forelegs. The serum concentrations of Ca, P and ALP and the plasma concentration of vitamin C differed significantly (P = 0.05) between age groups and there was a significant (P = 0.001) positive correlation between the levels of vitamin C in plasma and the serum levels of ALP at 6 weeks of age. The aim of the present study was to determine if there was any association between the plasma levels of vitamin C and the extent of crooked or deviated forelegs in growing-finishing pigs. We could not find a vitamin C deficiency during the study and no association between low levels of vitamin C in plasma and the presence of deformed forelegs of these 40 pigs.

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Section: Discussionmentioning

confidence: 99%

Vitamin C Plasma Concentrations and Leg Weakness in the Forelegs of Growing Pigs

Armocida¹,

Beskow²,

Amcoff³

et al. 2001

Journal of Veterinary Medicine Series A

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“…It seems reasonable to suggest that administration of glucose had a favourable effect on A A synthesis in the liver by securing a sufficient supply of the basic pre cursor. In this connection, one may do well to recall the observation of Brown et al [1970] who found a correlation between energy intake and blood serum AA levels in piglets aged 85-95 days. The results obtained in fasted piglets have confirmed that the level of the substrate is an important factor determining the degree of endogenous synthesis of AA.…”

Section: Discussionmentioning

confidence: 99%

“…The endogenous synthesis of AA can no doubt be affected by a number of factors in either a positive or negative sense [Chaterjee et al, 1961;Touster and Hollann, 1961;K linger and Ankerman, 1965;DvoftAic, 1967b;Brown et al, 1970]. In this connexion, much consideration has been given to stress [Van Koetsveld, 1968;Coates, 1968].…”

Section: Introductionmentioning

confidence: 99%

Effects of Corticotrophin, Starvation and Glucose on Ascorbic Acid Levels in the Blood Plasma and Liver of Piglets

Dvořák¹

1974

Ann Nutr Metab

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Total fasting and thirsting of piglets for 48 h produced a decrease in the ascorbic acid (AA) content of the liver, while the blood plasma AA levels remained unchanged or were increased. The changes were more marked in piglets less than 1 week old than in piglets aged 6–7 weeks. Administration of glucose to newborn fasted piglets restricted the decrease in AA levels in the liver. Administration of ACTH to conventionally fed piglets produced no adverse effects on their AA metabolism. It is concluded that the level of glucose is an important positive factor determining the degree of endogenous synthesis of AA. Possible effects of stress are discussed.

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“…( I 970) reported that supplementary ascorbic acid at levels up to 440 mg/kg of diet did not produce consistent responses in growth rate or ieed efficiency of swine. On the other hand, stress such as increased environmental temperatures (Riker et al 1967) or decreased energy intake (Brown et al 1970) resulted in depressed serum ascorbic acid levels in swine. Evidence has been presented (Brown et al 1970) to indicate that energy deprivation during the early growth phase prevented a rise in serum ascorbic acid values found in animals fed adequate levels of energy.…”

mentioning

confidence: 99%

“…On the other hand, stress such as increased environmental temperatures (Riker et al 1967) or decreased energy intake (Brown et al 1970) resulted in depressed serum ascorbic acid levels in swine. Evidence has been presented (Brown et al 1970) to indicate that energy deprivation during the early growth phase prevented a rise in serum ascorbic acid values found in animals fed adequate levels of energy. More recently, Dvoi:ik (1974) de-monstrated that ascorbic acid synthesis in young swine was a function of available glucose.…”

mentioning

confidence: 99%

Ascorbic Acid Metabolism in Swine. The Effects of Frequency of Feeding and Level of Supplementary Ascorbic Acid on Swine Fed Various Energy Levels

Brown¹,

Buchanan-Smith²,

Sharma³

1975

Can. J. Anim. Sci.

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of metabolizable energy (ME) was investigated using a 3 x 3 x 2 factorial experiment. Frequency of feeding had no influence on the growth rate within any one energy group. Supplementary ascorbic acid up to the level of 1,000 mg per day produced improvement in growth rates at all levels of ME intake. The improvement in rate of growth appeared not to be due to water retention because there were no differences in creatinine excretion rates (per kg ofbody weight per day) between any of the groups. Ascorbic acid supplementation at the rate of I ,000 mglday resulted in an increased proportion of the label from glucose-U-raC incorporated into the saponifiable fraction of an adipose tissue biopsy from the group fed a daily ration of 140 kcal ME/kg gyro zs in five equal amounrs during the day. Supplementary ascorbic acid appeared to have no other effects on lipid metabolism. Excretion of ascorbic acid was significantly increased when there was an increased ME intake and an tncreased level of vitamin supplementation. These observations confirm an earlier repoft that the ascorbic acid available to the swine is a function ofthe energy level in the diet. It is suggested that observations (vide supra) made in ME-deprived animals may be due to decreased amounts of ascorbic aiid physiologically available to the prg.

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Ascorbic Acid Metabolism in Swine. Interrelationships Between the Level of Energy Intake and Serum Ascorbate Levels

Cited by 11 publications

References 4 publications

Vitamin C Plasma Concentrations and Leg Weakness in the Forelegs of Growing Pigs

Vitamin C Plasma Concentrations and Leg Weakness in the Forelegs of Growing Pigs

Effects of Corticotrophin, Starvation and Glucose on Ascorbic Acid Levels in the Blood Plasma and Liver of Piglets

Ascorbic Acid Metabolism in Swine. The Effects of Frequency of Feeding and Level of Supplementary Ascorbic Acid on Swine Fed Various Energy Levels

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