Effects of vitamins A and D on the biosynthesis of <scp>l</scp>-ascorbic acid by rat-liver microsomes

Ghosh, Nilabja; Chatterjee, I. B.; Chatterjee, Gaurav

doi:10.1042/bj0970247

Cited by 12 publications

(3 citation statements)

References 17 publications

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“…Because ascorbic acid is synthesised in the yolk sac membrane during embryonic development (Yew, 1985) it is possible to suggest a regulating role for vitamin A in this process. For example, in rats excess vitamin A supplementation was associated with decreased ascorbic acid synthesis (Ghosh et al, 1965). On the other hand the effect may be indirect by changing the concentration of vitamin E which is considered to stimulate ascorbic acid synthesis in chicken tissues (Nagorna-Stasiak et al, 1997).…”

Section: Discussionmentioning

confidence: 98%

Effect of supplementing the hen's diet with vitamin A on the accumulation of vitamins A and E, ascorbic acid and carotenoids in the egg yolk and in the embryonic liver

Surai¹,

Іонов²,

Kuklenko³

et al. 1998

British Poultry Science

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1. The effect of a range of supplementations of vitamin A to the laying hen on the concentration of vitamins A, E, ascorbic acid and carotenoids in the maternal liver, the egg yolk and the embryonic liver were investigated. 2. Four groups of 25 Rhode Island Red hens were fed on standard layer-breeder diets with concentrations of supplemented vitamin A ranging from 0 to 120 micrograms/g retinol equivalents from 28 weeks of age. After 3 months, the concentration of vitamin A in the maternal liver was found to be greatly enhanced in proportion to the increasing rates of supplementation with the vitamin. However, the concentration of vitamin E in the maternal liver was markedly reduced by high dietary contents of vitamin A. 3. The concentration of vitamin A in the yolk of the hens' eggs was markedly increased by the dietary supplementation. However, the concentration of both vitamin E and carotenoids in the yolks were significantly reduced by high dietary contents of vitamin A. 4. The concentration of vitamin A in the liver of the embryo and the day old chick was greatly increased by the high concentrations of maternal vitamin A provision. However, the concentration of vitamin E, carotenoids and ascorbic acid in the embryonic/neonatal liver were significantly reduced by high contents of vitamin A in the maternal diet. 5. The susceptibility of the embryonic/neonatal liver to lipid peroxidation was significantly increased as a result of high provisions of maternal vitamin A. 6. It is concluded that excessive provision of vitamin A to the laying hen results in an adverse effect on vitamin E, carotenoids and ascorbic acid in the embryonic/neonatal liver and can compromise the antioxidant status of the progeny.

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Section: Discussionmentioning

confidence: 98%

Effect of supplementing the hen's diet with vitamin A on the accumulation of vitamins A and E, ascorbic acid and carotenoids in the egg yolk and in the embryonic liver

Surai¹,

Іонов²,

Kuklenko³

et al. 1998

British Poultry Science

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show abstract

“…Various workers have also reported a direct association between vitamin A deficiency and ascorbic acid synthesis. In 1965, Ghosh et al (31) reported that microsomal conversion of L-gulonolactone into L-ascorbic acid was impaired in the liver tissue of rats made deficient with respect to vitamin A. In our studies, we found that the protein status of the animals had a significant effect on the levels of vitamins A and C. As compared to the Std diet, in SHP there was a significant increase in the levels of vitamins A and C, while in the SLP diet there was a significant decrease in their levels.…”

Section: Discussionmentioning

confidence: 98%

Modulations in the biotransformation of tobacco extract and N′‐nitrosonornicotine under differential dietary protein status

Ammigan

Nair

Amonkar

et al. 1989

J. Biochem. Toxicol.

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The modulation of the phase I and phase II biotransformation enzymes upon treatment with tobacco extract (TE) and N'-nitrosonornicotine (NNN) was investigated using male Sprague-Dawley rats fed differential protein diets. It was observed that the animals fed a low protein diet showed an overall decrease in the basal levels of hepatic and pulmonary phase I and II enzymes. TE and NNN significantly decreased the detoxifying system in the low-protein-fed animals. Animals fed 20% protein, however, showed significant increases in glutathione and glutathione S-transferase upon treatment. Furthermore, TE and NNN treatment brought about a significant depletion in the hepatic pool of vitamin A with a concomitant increase in the vitamin C levels.

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“…Decreases in blood plasma ascorbic acid levels were reported to accompany vitamin A depletion of calves (Moore and Cotter, 1945) and chicks ). Malathi and Ganguly (1964) and Ghosh ^ (1967) have reported that activity of L-gulono-y-lactone oxidase is reduced in vitamin Adeficient rats. Rogers (1969), however, noted that the loss in enzymatic activity may be a result of reduced nutrient intake.…”

Section: Vitamin a By Ascorbic Acid Interactionmentioning

confidence: 99%

Effect of dietary vitamin A, ascorbic acid and their interaction on turkey bone mineralization

Dorr

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Effects of vitamins A and D on the biosynthesis of l-ascorbic acid by rat-liver microsomes

Cited by 12 publications

References 17 publications

Effect of supplementing the hen's diet with vitamin A on the accumulation of vitamins A and E, ascorbic acid and carotenoids in the egg yolk and in the embryonic liver

Effect of supplementing the hen's diet with vitamin A on the accumulation of vitamins A and E, ascorbic acid and carotenoids in the egg yolk and in the embryonic liver

Modulations in the biotransformation of tobacco extract and N′‐nitrosonornicotine under differential dietary protein status

Effect of dietary vitamin A, ascorbic acid and their interaction on turkey bone mineralization

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