Aspectos históricos de la esclerosis múltiple

Moreira, Marcos Aurélio; Tilbery, Charles Peter; Lana-Peixoto, M. A.; Mendes, Maria Fernanda; Kaimen-Maciel, Damacio Ramón; Callegaro, D.

doi:10.33588/rn.3404.2001313

Cited by 11 publications

(8 citation statements)

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“…Multiple sclerosis (MS) is a chronic demyelinating central nervous system disease with time and space disseminated lesions that usually have a relapsing remitting course and affect the periventricular region, optical nerves, and spinal cord [1]. It affects around 2.5 million people worldwide and it is one of the most frequent neurological illnesses and cause of disability among young adults, especially in Europe and North America [2].…”

Section: Introduction: Rationale and Objectivesmentioning

confidence: 99%

Suicide risk in multiple sclerosis: A systematic review of current literature

Pompili

Forte

Palermo

et al. 2012

Journal of Psychosomatic Research

145

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Section: Introduction: Rationale and Objectivesmentioning

confidence: 99%

Suicide risk in multiple sclerosis: A systematic review of current literature

Pompili

Forte

Palermo

et al. 2012

Journal of Psychosomatic Research

145

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“…Taken together, the results of bioinformatics screening provide strong tools for prediction of unexpected candidates. There are, however, many coding and noncoding loci that seems to be related with MS due to several clinical symptoms, including demyelination, inflammatory wounds, exocytopenia, inappropriate cell activation of Th1‐producing IFNγ, an inadequate activation of Th17‐producing IL‐17 cells, as well as the over‐activation of intrinsic immune cells; macrophages, microglia, neutrophils, and dendritic cells (Y. Chen et al, ; Moreira et al, ; Tabarkiewicz, Pogoda, Karczmarczyk, Pozarowski, & Giannopoulos, ).…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis of OIP5‐AS1/HUR1 to discover new potential biomarkers and therapeutic targets in multiple sclerosis

Gharesouran

Taheri

Sayad

et al. 2019

Journal Cellular Physiology

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Multiple sclerosis (MS) is a devastating autoimmune disease of the central nervous system associated with demyelination and axonal injury. This study was designed to find potential lncRNAs and their targets that are associated with the molecular basis of MS pathogenesis. In this study, peripheral blood samples were obtained from 50 relapsing‐remitting MS (RR‐MS) patients and 50 healthy controls. lncRNAs and their target were selected for validation using TaqMan Real‐Time PCR. Interactions were studied based on approaches that used to investigation biological functions and signaling pathways affected by differentially expressed messenger RNAs (mRNAs). The results of this study indicate an increase in the expression of HUR1 (p = 0.0001), CPSF7 (p = 0.02), and reduction of CSTF2 expression (p = 0.04). Also, an increase in the expression of OIP5‐AS1 (p = 0.01) was observed in men less than 30 years old. We performed a comparative analysis of the long noncoding RNAs (lncRNAs), and then we ranked them as candidate biomarkers according to a decreasing area under the receiver operating characteristic (ROC) curve (AUC) and plotted the results. Dysregulation of lncRNA expression has been linked to diseases. Further studies on the HUR1 gene can be used as diagnostic tools for the identification of high‐risk individuals in families with a history of disease before, during, and even after treatment. Our data uncovered the expression profiles of lncRNAs and mRNAs in MS patients, which will help delineate the molecular mechanisms in MS pathogenesis. However, further studies need to determine the precise role of these genes in the pathological process in MS.

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“…However, Clymer's report could have had a scarce diffusion; the uncertain place of mental disorders caused by diseases such as MS, of proven "organic" origin [35] in the American medical world, could also have had a role. Another pioneer of the recognition of MS as a specific disease in the USA was Edward Seguin (1878), who is also credited with the first use of the name "multiple sclerosis" [36,37].…”

Section: The Era Of Charcot and Contemporary Cliniciansmentioning

confidence: 99%

Focus or Neglect on Cognitive Impairment Following the History of Multiple Sclerosis

Nocentini

2023

NeuroSci

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Cognitive disorders are now considered an integral part of the picture of multiple sclerosis. If we trace the history of the accounts of this disease, from the early descriptions by Jean-Martin Charcot, the first to provide systematic characteristics of multiple sclerosis, to present-day accounts, reports of cognitive disturbances have demonstrated an alternating trend. Cognitive disturbances were identified in the beginning, quite clearly for the times. Then, for a long time, they were considered infrequent or attributed to other factors. Finally, since the 1980s, cognitive disturbances have been the subject of increasingly in-depth studies, and are currently assumed to be a very important consequence of multiple sclerosis. In this work, the history of the description of cognitive disorders of multiple sclerosis will be retraced by analyzing the possible reasons for the differences in attention they have received over time. It emerged from the analysis that, as in the case of other pathologies, various factors have influenced how cognitive disorders have been taken into consideration. Some of these factors are inherent to the very nature of the cognitive impairments present in multiple sclerosis; others are linked to historical periods, or to the different ways of approaching the analysis of the phenomena caused by a disease. The reflections made on these topics should, among other things, increase our awareness of how scientific investigation is invariably placed in the historical context in which it is carried out.

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Aspectos históricos de la esclerosis múltiple

Cited by 11 publications

References 0 publications

Suicide risk in multiple sclerosis: A systematic review of current literature

Suicide risk in multiple sclerosis: A systematic review of current literature

Integrative analysis of OIP5‐AS1/HUR1 to discover new potential biomarkers and therapeutic targets in multiple sclerosis

Focus or Neglect on Cognitive Impairment Following the History of Multiple Sclerosis

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