Suicide risk in multiple sclerosis: A systematic review of current literature

Pompili, Maurizio; Forte, Alberto; Palermo, Mario; Stefani, Henry; Lamis, Dorian A.; Serafini, Gianluca; Amore, Mario; Girardi, Paolo

doi:10.1016/j.jpsychores.2012.09.011

Cited by 145 publications

(104 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study we used the Patient Health Questionnaire depression module short version (PHQ-2). The PHQ-2 is scored in response to the question: 'Over the past 2 weeks, how often have you been bothered by any of the following problems: Little interest or pleasure in doing things; Feeling down, depressed, or hopeless' as follows: Not at all [0], Several days [1], More than half the days [2], Nearly every day [3]. The PHQ-2 is a shortened form of the PHQ-9 which has shown good criterion and construct validity.…”

Section: Depressionmentioning

confidence: 99%

See 1 more Smart Citation

Lifestyle factors, demographics and medications associated with depression risk in an international sample of people with multiple sclerosis

et al. 2014

View full text Add to dashboard Cite

Background: Depression is the most common co-morbidity for people with Multiple Sclerosis (MS); irrespective of disease severity, depression has the greatest impact on quality of life. An emerging paradigm in the treatment of depression is lifestyle medicine. There is significant potential to prevent and treat depression through modification of lifestyle risk factors for people with MS. This study sought to understand the association between lifestyle risk factors, medication and depression risk through the analysis of self-reported data from a large international sample of people with MS. Methods: This cross-sectional analysis recruited a total of 2459 participants via Web 2.0 platforms. Survey data included socio-demographics; a range of lifestyle risk factors; medication; disease variables and depression risk using the Patient Health Questionnaire-2 (PHQ-2). Results: In total approximately one fifth (19.3%) of our sample screened positive for depression (PHQ-2 score ≥3). Several demographic factors were significantly associated with this depression risk in bivariate analysis. Regression analyses showed that poor diet, low levels of exercise, obesity, smoking, marked social isolation and taking interferon were associated with greater depression risk. Participants who supplemented with omega 3s, particularly flaxseed oil, had frequent fish consumption, supplemented with vitamin D, meditated, and had moderate alcohol consumption had significantly reduced depression risk. Conclusions: This study demonstrates a significant association between modifiable lifestyle factors and depression risk. Planned longitudinal follow up may clarify causality. Clinicians and people with MS should be aware of the wide range of modifiable lifestyle factors that may reduce depression risk as part of a comprehensive secondary and tertiary preventive medical approach to managing MS.

show abstract

Section: Depressionmentioning

confidence: 99%

“…Depression is the most common psychiatric illness and co-morbidity for people with MS, who are also at higher risk of suicide and self-harm than others in the population [2]. Severity of depression is a risk factor associated with suicide risk.…”

Section: Introductionmentioning

confidence: 99%

Lifestyle factors, demographics and medications associated with depression risk in an international sample of people with multiple sclerosis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Chronic illnesses like cancer, asthma, musculoskeletal and cardiovascular disease may play a role in the development of suicidal behaviours, varying as a function of the presence of subsequent mental disorder (Bolton et al, 2015;Webb et al, 2012). Perhaps unsurprisingly, numerous studies have found depression to be the most common psychiatric diagnosis among chronic physically ill patients, being associated with a higher suicide risk (Anguiano et al, 2012;Pompili et al, 2012;Pompili et al, 2014;Webb et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The role of physical and mental health multimorbidity in suicidal ideation

Kavalidou

Smith

O’Connor

2017

Journal of Affective Disorders

View full text Add to dashboard Cite

show abstract

“…Está demostrado, sin embargo, que existe una alta correlación entre el suicidio y los trastornos mentales 14,15 , cuyo tratamiento realizan médicos, y de aquí la progresiva medicalización del problema 3,4 . Pese a esta asociación es importante no perder de vista que el suicidio es un fenómeno mucho más complejo, que trasciende los límites de la enfermedad mental y la medicina, siendo conocidos los ejemplos de conductas suicidas en otros contextos como ocurre en una serie de situaciones sociales, como manifestación de descontento social, como opción de honorabilidad, como una muerte altruista o ante enfermedades somáticas terminales o que involucran dolor o limitaciones crónicas 16,17 .…”

Section: Medicalización Del Suicidiounclassified