Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice

Shi, Qiong; Song, Xiufang; Fu, Juanli; Su, Chuanyang; Xia, Xiaomin; Song, Erqun; Song, Yang

doi:10.1016/j.intimp.2015.09.003

Cited by 49 publications

(39 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…T‐AOC refers to the total antioxidant capacity of all the endogenous and exogenous antioxidants such as uric acid, Trolox, vitamin C, glutathione (GSH), bilirubin, and (±)‐catechin (Baltacioglu et al, ). In the present study, a slightly increased plasma T‐AOC activity was observed as compared to the control group (Table ), which was in accordance with the findings by Shi et al (), who reported that the paraquat group had significantly lower T‐AOC as compared to the control group ( p < .01); whereas, the neohesperidin dihydrochalcone‐treated group showed only slightly increased T‐AOC activity as compared to the paraquat group.…”

Section: Discussionsupporting

confidence: 92%

“…In order to defend the oxidative injuries, the body possesses antioxidant enzymes, including SOD, CAT, and GSH‐Px and antioxidants such as glutathione and some vitamins were estimated (Huangfu et al, ; Shi et al, ). In this study, the activities of SOD, CAT, and GSH‐Px were enhanced by a diet supplemented with phlorizin during high‐fat consumption (Table ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Apple phlorizin supplementation attenuates oxidative stress in hamsters fed a high-fat diet

et al. 2017

View full text Add to dashboard Cite

Phlorizin from apple peel has been used as a nutrient for more than 100 years. The present study investigated the effects of phlorizin on the antioxidant capacity and the antioxidative mechanisms in hamsters fed high-fat diet supplemented with phlorizin (0.3, 0.6, and 0.9%). Results showed that phlorizin increased the antioxidant enzyme activities and reduced the malondialdehyde content in plasma, liver, heart, and kidney that might arise from the higher mRNA levels of CuZn-superoxide dismutase, Mn-superoxide dismutase (Mn-SOD), catalase, glutathione peroxidase, nuclear factor erythroid 2-related factor 2-like (Nrf2), and the protein expression of Mn-SOD (p < .05). Diet supplemented with phlorizin also significantly decreased the total cholesterol and triglycerides levels in plasma. The present study demonstrated that phlorizin might reduce lipid peroxidation and protect against cardiovascular issues in vivo. Practical applicationsPhlorizin, from apple peel, has been used as a nutrient for over 100 years. To date, despite extensive research on phlorizin, a report on its effect on lipid peroxidation, the antioxidant system in plasma, heart, liver, and kidney of hamsters fed high-fat diet is yet lacking. This report demonstrates that phlorizin can reduce lipid peroxidation and exert a protective effect on cardiovascular issues in vivo, which is valuable in the rational utilization of phlorizin in functional foods. K E Y W O R D Santioxidant capacity, cholesterol, hamsters, phlorizin

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Apple phlorizin supplementation attenuates oxidative stress in hamsters fed a high-fat diet

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Apart from the inflammatory response and oxidative stress, apoptosis may be another culprit in the hepatotoxic events of PQ poisoning [ 46 ]. In the current study, three apoptosis-related genes, Bax, Bcl-2, and p53, were investigated.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol and Montelukast Alleviate Paraquat‐Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis

El-Boghdady

Abdeltawab

Nooh

2017

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Paraquat (PQ) is one of the most used herbicide worldwide. Its cytotoxicity is attributed to reactive radical generation. Resveratrol (Res) and montelukast (MK) have anti-inflammatory and antioxidant properties. The protective effects of Res, MK, or their combination against PQ-induced acute liver injury have not been investigated before. Therefore, we explored the protective potential of Res and/or MK against PQ hepatic toxicity in a mouse model. Mice were randomly assigned to five groups: group I served as the normal control and group II received a single dose of PQ (50 mg/kg, i.p.). Groups III, IV, and V received PQ plus oral Res (5 mg/kg/day), MK (10 mg/kg/day), and Res/MK combination, respectively. Res and/or MK reduced PQ-induced liver injury, evidenced by normalization of serum total protein, ALT, and AST. Res and/or MK significantly reversed PQ-induced oxidative stress markers glutathione and malondialdehyde. Res and/or MK significantly reduced PQ-induced inflammation reflected in TNF-α levels. Furthermore, Res and/or MK reversed PQ-induced apoptosis assessed by differential expression of p53, Bax, and Bcl-2. Histopathologic examination supported the biochemical findings. Although Res and MK displayed antioxidative, anti-inflammatory, and antiapoptotic activities, their combination was not always synergistic.

show abstract

“…In this study, we aimed to study the anti-inflammatory activities of QFAE in vitro and in vivo . Previous studies have shown that FA contains naringin, hesperidin, synephrine, narirutin, neohesperidin, didymin, nobiletin, tangeretin, auraptene, neoeriocitrin, poncirin, and other substances 19 – 21 , which have anti-inflammatory effects because of its components, such as naringin 22 – 24 , hesperidin 23 , 24 , synephrine 25 , narirutin 26 , neohesperidin 27 , and nobiletin 28 . In our experiment, we detected the content of naringin in QFAE, which was used as a criterion for the quality control and quantification of QFAE.…”

Section: Discussionmentioning

confidence: 99%

Role of Quzhou Fructus Aurantii Extract in Preventing and Treating Acute Lung Injury and Inflammation

Zhang

Xin

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Quzhou Fructus Aurantii (QFA) is an authentic herb of local varieties in Zhejiang, China, which is usually used to treat gastrointestinal illnesses, but its effects on respiratory inflammation have not been reported yet. In our study, the anti-inflammatory activity of QFA extract (QFAE) was evaluated on copper sulfate pentahydrate (CuSO4·5H2O)-induced transgenic neutrophil fluorescent zebrafish model. QFAE showed a significant effect of anti-inflammation in CuSO4·5H2O-induced zebrafish by reducing the neutrophil number in the inflammatory site. We investigated the anti-inflammatory activity of QFAE on lipopolysaccharide (LPS)-induced acute lung injury (ALI) mice models and RAW 264.7 cells. QFAE had an anti-inflammatory effect on reducing total cells, neutrophils, and macrophages in BALF and attenuated alveolus collapse, neutrophils infiltration, lung W/D ratio, myeloperoxidase (MPO) protein expression and other pulmonary histological changes in lung tissues, as well as hematological changes. Levels of pro-inflammatory cytokines, including TNF, IL-6, IFN-γ, MCP-1, and IL-12p70, were decreased, whereas anti-inflammatory cytokine IL-10 was increased after treatment with QFAE both in vivo and in vitro. In summary, our results suggested that QFAE had apparent anti-inflammatory effects on CuSO4·5H2O-induced zebrafish, LPS-induced ALI mice, and RAW 264.7 cells. Furthermore, QFAE may be a therapeutic drug to treat ALI/ARDS and other respiratory inflammations.

show abstract

Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice

Cited by 49 publications

References 29 publications

Apple phlorizin supplementation attenuates oxidative stress in hamsters fed a high-fat diet

Apple phlorizin supplementation attenuates oxidative stress in hamsters fed a high-fat diet

Resveratrol and Montelukast Alleviate Paraquat‐Induced Hepatic Injury in Mice: Modulation of Oxidative Stress, Inflammation, and Apoptosis

Role of Quzhou Fructus Aurantii Extract in Preventing and Treating Acute Lung Injury and Inflammation

Contact Info

Product

Resources

About