Are children with idiopathic nephrotic syndrome at risk for metabolic bone disease?

Gulati, Sanjeev; Godbole, Madan M.; Singh, Uttam; Gangarapu, Kiran; Srivastava, Arvind

doi:10.1016/s0272-6386(03)00348-2

Cited by 66 publications

(64 citation statements)

References 25 publications

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“…Nephrotic syndrome was defined as per the diagnostic criteria laid by International Study of Kidney Disease in Children (ISKDC) as mentioned in our earlier study [14].The NS in children was defined as proteinuria of 40 mg/m 2 /h or spot urine protein (mg)/creatinine (mg) ratio of 2 in first morning urine sample. The remission of NS was defined by urinary protein excretion \4 mg/m 2 /h or urine dipstix nil/trace for three consecutive days.…”

Section: Methodsmentioning

confidence: 99%

Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

et al. 2011

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Section: Methodsmentioning

confidence: 99%

Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

et al. 2011

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“…Their mean age at diagnosis was 4.8 ± 3.4 years (range, 1-18 years), They presented to the OPD at our hospital from January 2005 to January 2008. All patients were diagnosed according to the International Study of Kidney Disease in Children (ISKDC) criteria as deÞ ned in our earlier study, [6] and all of them had developed nephrotic syndrome before the age of 18 years. Patients with poor compliance and not on regular follow-up were excluded from the study.…”

Section: Patientsmentioning

confidence: 99%

Does cytokine gene polymorphism affect steroid responses in idiopathic nephrotic syndrome?

Tripathi¹,

Jafar²,

Mandal³

et al. 2008

Indian J Med Sci

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BACKGROUND: Immunological responses may be possibly involved in the pathogenesis of idiopathic nephrotic syndrome (INS). Cytokines act as a potent immunomodulator. Pathogenesis of INS is associated with Th1 and Th2 cytokines imbalance. AIMS, SETTINGS AND DESIGN:We have investigated the association of OR = 14.71, and P = 0.0386, OR = 7.29,). TNF-α revealed a strong association at genotypic level (P = 0.0121, OR = 14.71,, as well as at allelic level (P = 0.0433, OR = 2.251,

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“…The idiopathic nephrotic syndrome is accompanied by primary glomerular disease (1,2). These children show 3+ or 4+ proteinuria, and hematuria in microscopic level is shown in 20% of children.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Status in Children with Nephrotic Syndrome

et al. 2017

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Introduction: Children with nephrotic syndrome (NS) are treated for 12 weeks with prednisolone regarding the damage to the bones. Deficiency in the level of vitamin D damages the bones. Assessment of vitamin D status in children with NS is based on serum 25OHD3 level taking into consideration the type of steroid susceptible (SS), steroid dependent (SD), and steroid resistance (SR) nephrotic syndrome (NS). Methods: This study was a prospective study on children with the first visit of NS before treatment with prednisolone. The glomerular filtration rate (GFR) was calculated with Schwartz formula, and only sick people with normal GFR were included in the study. Analysis of 218 children aged 1-13 years, median 9.5 [108 with SSNS, 64 with SDNS, and 46 with SRNS] was performed. Serum concentrations of 1,25(OH)2 D3, calcium, phosphorus, and creatinine were measured. The correlation of 25OHD3 with the type of nephrotic syndrome, seasons, gender, and age was investigated. Results: A total of 218 children were examined. Vitamin D level was deficient (< 10 ng/mL) in 79% of SRNS, 83% of SDNS, and 17% of SSNS group (P value 0.0001), insufficient (10 -30 ng/mL) in 81% of SRNS, 73% of SDNS, and 9% of SSNS group (P value = 0.0003), and sufficient (30 -150 ng/mL) in 91% of SSNS, 17% of SDNS, and 7% of SRNS group (P value = 0.002). Conclusions: Our results suggest the necessity of developing new strategies in vitamin D supplementation in children with INS.

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Are children with idiopathic nephrotic syndrome at risk for metabolic bone disease?

Cited by 66 publications

References 25 publications

Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

Cytokine Gene Polymorphism in Idiopathic Nephrotic Syndrome Children

Does cytokine gene polymorphism affect steroid responses in idiopathic nephrotic syndrome?

Vitamin D Status in Children with Nephrotic Syndrome

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