Aptamer-Based Biosensors for Antibiotic Detection: A Review

Mehlhorn, Asol; Rahimi, Parvaneh; Joseph, Yvonne

doi:10.3390/bios8020054

Cited by 207 publications

(118 citation statements)

References 240 publications

(323 reference statements)

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“…Aptamer-based biosensors have been used for accurate and rapid detection of disease markers, pathogens, antibiotics, toxins, pollutes, and other chemicals or biomolecules. [30][31][32][33][34]…”

Section: Aptamer-based Biosensorsmentioning

confidence: 99%

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Guan¹,

Zhang²

2020

IJN

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Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery.

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Section: Aptamer-based Biosensorsmentioning

confidence: 99%

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Guan¹,

Zhang²

2020

IJN

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“…With regard to the possible adverse effects of human and veterinary antibiotics in the environment and food, the rapid and effective detection of antibiotics is particularly important. At present, the usual methods for the antibiotics detection mainly include high performance liquid chromatography (HPLC) [159], liquid chromatography-mass spectrometry (LC-MS/MS) [160], capillary electrophoresis (CE) [161], enzyme-linked immunosorbent assay (ELISA) [162] and photoelectric/colorimetric sensors [163]. MOFs can be used as a solid-phase microextraction adsorption material to enrich antibiotics in food [164] or water [165].…”

Section: Antibiotic Detectionmentioning

confidence: 99%

Recent Progress on Luminescent Metal-Organic Framework-Involved Hybrid Materials for Rapid Determination of Contaminants in Environment and Food

et al. 2020

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The high speed of contaminants growth needs the burgeoning of new analytical techniques to keep up with the continuous demand for monitoring and legislation on food safety and environmental pollution control. Metal-organic frameworks (MOFs) are a kind of advanced crystal porous materials with controllable apertures, which are self-assembled by organic ligands and inorganic metal nodes. They have the merits of large specific surface areas, high porosity and the diversity of structures and functions. Latterly, the utilization of metal-organic frameworks has attracted much attention in environmental protection and the food industry. MOFs have exhibited great value as sensing materials for many targets. Among many sensing methods, fluorometric sensing is one of the widely studied methods in the detection of harmful substances in food and environmental samples. Fluorometric detection based on MOFs and its functional materials is currently one of the most key research subjects in the food and environmental fields. It has gradually become a hot research direction to construct the highly sensitive rapid sensors to detect harmful substances in the food matrix based on metal-organic frameworks. In this paper, we introduced the synthesis and detection application characteristics (absorption, fluorescence, etc.) of metal-organic frameworks. We summarized their applications in the MOFs-based fluorometric detection of harmful substances in food and water over the past few years. The harmful substances mainly include heavy metals, organic pollutants and other small molecules, etc. On this basis, the future development and possible application of the MOFs have prospected in this review paper.

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“…For example, transport needs to be refrigerated and antibodies/nanobodies need to be kept cool to ensure they remain functional, whereas aptamers are stable at higher temperatures [53,100]. Additionally, while aptamers have been used to replace antibodies in typical laboratory tests, they have also come into their own in a number of in vitro diagnostic assays that would be easily adapted to in field or POCT [101][102][103][104].…”

Section: In Vitro Applications: Which Is Best?mentioning

confidence: 99%

Antibodies, Nanobodies, or Aptamers—Which Is Best for Deciphering the Proteomes of Non-Model Species?

Dhar

Samarasinghe

Shigdar

2020

IJMS

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This planet is home to countless species, some more well-known than the others. While we have developed many techniques to be able to interrogate some of the “omics”, proteomics is becoming recognized as a very important part of the puzzle, given how important the protein is as a functional part of the cell. Within human health, the proteome is fairly well-established, with numerous reagents being available to decipher cellular pathways. Recent research advancements have assisted in characterizing the proteomes of some model (non-human) species, however, in many other species, we are only just touching the surface. This review considers three main reagent classes—antibodies, aptamers, and nanobodies—as a means of continuing to investigate the proteomes of non-model species without the complications of understanding the full protein signature of a species. Considerations of ease of production, potential applications, and the necessity for producing a new reagent depending on homology are presented.

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Aptamer-Based Biosensors for Antibiotic Detection: A Review

Cited by 207 publications

References 240 publications

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Recent Progress on Luminescent Metal-Organic Framework-Involved Hybrid Materials for Rapid Determination of Contaminants in Environment and Food

Antibodies, Nanobodies, or Aptamers—Which Is Best for Deciphering the Proteomes of Non-Model Species?

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