Applications of Carbon Nanotubes in Bone Regenerative Medicine

Tanaka, Manabu; Aoki, Katsumi; Haniu, Hisao; Kamanaka, Takayuki; Takizawa, Takashi; Sobajima, Atsushi; Yoshida, Kazuhide; Okamoto, Masato; Kato, Hiroyuki

doi:10.3390/nano10040659

Cited by 26 publications

(15 citation statements)

References 104 publications

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“…The mechanical properties of CNFs are inferior to those of MWNTs due to the presence of more crystalline defects. From biomedical perspective, carbonaceous nanomaterials promote the adhesion, growth and differentiation of bone cells [70][71][72][73][74][75][76][77][78][79][80][81]. For instance, MWNTs show potential applications as structural biomaterials and reinforcing nanofillers for degradable polymer scaffolds for bone tissue engineering (Figure 23) [191][192][193].…”

Section: Peek-cnt Nanocompositesmentioning

confidence: 99%

“…Thus, nHA is incorporated into both degradable and non-degradable polymers for enhancing osteoblastic adhesion and proliferation [60][61][62][63][64][65][66][67][68][69]. Apart from nHA, carbonaceous nanofillers of different dimensions such as carbon nanotubes (CNTs), carbon nanofibers (CNFs) and graphene oxide sheets also promote the adhesion, growth and differentiation of osteoblasts [70][71][72][73][74][75][76][77][78][79][80][81]. As a result, carbon-based nanomaterials are also incorporated into polymers for enhancing their biocompatibility in many tissue engineering applications [61][62][63][82][83][84][85][86].…”

Section: Introductionmentioning

confidence: 99%

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Polyetheretherketone and Its Composites for Bone Replacement and Regeneration

Liao

Tjong

2020

Polymers

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In this article, recent advances in the development, preparation, biocompatibility and mechanical properties of polyetheretherketone (PEEK) and its composites for hard and soft tissue engineering are reviewed. PEEK has been widely employed for fabricating spinal fusions due to its radiolucency, chemical stability and superior sterilization resistance at high temperatures. PEEK can also be tailored into patient-specific implants for treating orbital and craniofacial defects in combination with additive manufacturing process. However, PEEK is bioinert, lacking osseointegration after implantation. Accordingly, several approaches including surface roughening, thin film coating technology, and addition of bioactive hydroxyapatite (HA) micro-/nanofillers have been adopted to improve osseointegration performance. The elastic modulus of PEEK is 3.7–4.0 GPa, being considerably lower than that of human cortical bone ranging from 7–30 GPa. Thus, PEEK is not stiff enough to sustain applied stress in load-bearing orthopedic implants. Therefore, HA micro-/nanofillers, continuous and discontinuous carbon fibers are incorporated into PEEK for enhancing its stiffness for load-bearing applications. Among these, carbon fibers are more effective than HA micro-/nanofillers in providing additional stiffness and load-bearing capabilities. In particular, the tensile properties of PEEK composite with 30wt% short carbon fibers resemble those of cortical bone. Hydrophobic PEEK shows no degradation behavior, thus hampering its use for making porous bone scaffolds. PEEK can be blended with hydrophilic polymers such as polyglycolic acid and polyvinyl alcohol to produce biodegradable scaffolds for bone tissue engineering applications.

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Section: Peek-cnt Nanocompositesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polyetheretherketone and Its Composites for Bone Replacement and Regeneration

Liao

Tjong

2020

Polymers

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“…If CNTs are incorporated into composite materials for medical applications, evidence of their bioactivity and toxicity is essential. The presence of CNTs in the composite may have no detrimental effects and could even enhance its bioactive properties [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. A study by Georg et al [38] tested the response of MWCNTs to human lung epithelial cells, osteoblast-like cells and primary osteoblast cells.…”

Section: Introductionmentioning

confidence: 99%

Amino Acid Functionalization of Multi-Walled Carbon Nanotubes for Enhanced Apatite Formation and Biocompatibility

Haroun¹,

Gospodinova²,

Krasteva³

2021

Nano BioMed ENG

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The limitation in bone tissue engineering is the lack of available natural or synthetic biomaterials to replace bone tissue under need. Carbon nanotubes have great potential as bone tissue scaffolds because of their remarkable mechanical and electrical properties combined with high aspect ratio.In this work, we demonstrated for the first time a novel approach based on the sol-gel technique for functionalization of multi-walled carbon nanotubes (MWCNTs) with two amino acids: L-arginine, L(+) Arg and L-aspargine, L(+) Asp. We have examined the effect of both functionalities on physicochemical properties of MWCNTs, cytotoxicity in osteosarcoma MG63 and normal fibroblastic BJ cells and the ability to induce nucleation and growth of hydroxyapatite (HA) crystals in vitro under physiological concentrations of Ca 2+ and PO 4+ (SBF). The scaffolds were characterized using Fourier transform infrared spectroscopy (FTIR-ATR), dynamic light scattering technique (DLS), X-ray diffraction (XRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The results showed that both functionalized MWCNTs have a particle size of 269 and 411 nm, a zeta potential of -12.8 and -8.8 mV, respectively, high colloidal stability, enhanced biocompatibility, and enhanced formation of an apatite layer on the scaffolds surface in comparison to ox-MWCNTs. Altogether, the results confirmed the important role of the amino acids L(+) Arg and L(+) Asp in ox-MWCNTs-based composites for bone tissue engineering applications.

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“…[184][185][186] Both CNTs and the graphene family nanomaterials have also demonstrated some potential for regenerative medicine and tissue engineering. [187][188][189] The intrinsic fluorescent properties of NDs with high photostability may be exploited further for biomedical imaging and clinical diagnosis. [190,191] As previously mentioned, NDs are also being clinically evaluated for root canal therapy.…”

Section: Clinical Translation Of Carbon Nanomaterialsmentioning

confidence: 99%

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

Soltani

Guo

Bianco

et al. 2020

Advanced Therapeutics

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In the last decade, graphene‐based nanomaterials and carbon dots have joined the family of carbon materials mainly composed of graphite, diamond, fullerene, and carbon nanotubes. Carbon nanomaterials have been widely exploited in various fields from electronics and materials science to nanomedicine. The studies on their effect on the immune system have revealed that they possess intrinsic anti‐inflammatory properties, reducing the production of proinflammatory cytokines and modulating immune cell maturation. In addition, their large specific surface area associated with high biocompatibility allows their use as carriers for the delivery of anti‐inflammatory agents. They can also contribute to the diagnosis of inflammatory diseases as biosensors for low‐limit detection and quantification of inflammation‐related biomarkers in body fluids and tissues allowing to monitor the concentration of drugs in urine and guide personalized drug usage. Finally, they are used as adsorbents for blood plasma purification in the clinical treatment of sepsis through efficient removal of certain cytokines. This review focuses on the intrinsic anti‐inflammatory properties of carbon nanomaterials. An overview is provided on their use as carriers of anti‐inflammatory drugs, as biosensors, and for blood purification in the context of inflammatory diseases. The potential of carbon nanomaterials for clinical translation is also critically discussed.

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Applications of Carbon Nanotubes in Bone Regenerative Medicine

Cited by 26 publications

References 104 publications

Polyetheretherketone and Its Composites for Bone Replacement and Regeneration

Polyetheretherketone and Its Composites for Bone Replacement and Regeneration

Amino Acid Functionalization of Multi-Walled Carbon Nanotubes for Enhanced Apatite Formation and Biocompatibility

Carbon Nanomaterials Applied for the Treatment of Inflammatory Diseases: Preclinical Evidence

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