Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables

Dai, Yunliang; Row, Kyung Ho

doi:10.3390/molecules24122300

Cited by 52 publications

(29 citation statements)

References 36 publications

(36 reference statements)

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“…The recent incorporation of natural extracts of plants, fruits, and spices represents a promising approach for the development of active edible films, due to their high quantities of polyphenols, such as flavonoids, phenolic acids, and anthocyanins, which can improve the functionality of the film based on the antioxidant and antibacterial capacity of these compounds [ 6 , 7 ]. For this reason, there is currently a need to extract large amounts of bioactive compounds from plant resources using non-harmful and environmentally friendly solvents such as natural deep eutectic solvents (NADES) [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Anthocyanins Using Natural Deep Eutectic Solvents and Their Incorporation in Edible Films

et al. 2021

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Extracts rich in bioactive compounds added to edible films have allowed the development of active packaging that increases the shelf life of food. However, it is necessary to search for solvents that are nontoxic and not harmful to the environment, with natural deep eutectic solvents (NADES) being an attractive and easily synthesized alternative. This research aimed to design NADES by lyophilization to be used in the extraction of anthocyanins from the Chilean Luma chequen (Molina) A. Gray berry, and subsequently adding them to the matrix of edible ƙ-carrageenan films. For this purpose, ultrasound-assisted extraction (UAE) was used and the anthocyanin content was evaluated with the pH differential method. The antioxidant capacity of extracts was determined by DPPH assay and the antibacterial capacity by diffusion agar tests. The results obtained indicate that the designed NADES are efficient at extracting anthocyanins, reaching concentrations between 81.1 and 327.6 mg eq cyanidin 3-glucoside/100 g dw of L. chequen (Molina) A. Gray. The extracts reached inhibition diameters between 5 and 34 mm against Escherichia coli, Staphylococcus aureus, and Salmonella typhi strains. Once the extracts were incorporated into ƙ-carrageenan films, active edible films with antioxidant and antibacterial capacities were obtained.

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Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Extraction of Anthocyanins Using Natural Deep Eutectic Solvents and Their Incorporation in Edible Films

et al. 2021

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“…The interest in NADES is growing gradually. NADESs have been reported to be suitable for the extraction of anthocyanins [33][34][35], anthraquinones [36], catehins [37], flavonoids [38][39][40], phlorotannins [41], polysaccharides [42], etc. Rhizomes of R. rosea are used in traditional and officinal medicine in the form of aqueous infusion/decoctions or as ethanol-based tincture/extract [2,3,5,7].…”

Section: Introductionmentioning

confidence: 99%

Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.

Shikov

Косман²,

Flissyuk

et al. 2020

Molecules

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The extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett-Burman design with five variables, followed by the steepest ascent method, was undertaken to determine the optimal extraction conditions. Among the five parameters tested, particle size, extraction modulus, and water content were found to have the highest impact on the extrability of phenyletanes and phenylpropanoids. The concentration of active compounds was analyzed by HPLC. The predicted results showed that the extraction yield of the total phenyletanes and phenylpropanoids (25.62 mg/g) could be obtained under the following conditions: extraction time of 154 min, extraction temperature of 22 • C, extraction modulus of 40, molar water content of 5:1:11 (L-lactic acid:fructose:water, mol/mol), and a particle size of rhizomes of 0.5-1 mm. These predicted values were further verified by validation experiments in predicted conditions. The experimental yields of salidroside, tyrosol, rosavin, rosin, cinnamyl alcohol and total markers (sum of phenyletanes and phenylpropanoids in mg/g) were 11.90 ± 0.02, 0.36 ± 0.02, 12.23 ± 0.21, 1.41 ± 0.01, 0.20 ± 0.01, and 26.10 ± 0.27 mg/g, respectively, which corresponded well with the predicted values from the models.

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“…Moreover, the use of a high temperature in extraction may increase the energy consumption, which is contradictive to the green extraction principle [ 28 ]. A study conducted by Dai et al [ 29 ] highlighted that the extraction of flavonoid compounds can be carried out at ambient temperatures and provide the maximum extraction recovery for flavonoid compounds. Therefore, in this study, we decided to carry out the extraction process at room temperature, unlike our previous studies.…”

Section: Resultsmentioning

confidence: 99%

A green extraction design for enhancing flavonoid compounds from Ixora javanica flowers using a deep eutectic solvent

et al. 2020

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In this study, an environmentally friendly extraction method for flavonoid compound from Ixora javanica , as a new raw material candidate for herbal medicine and cosmetics, was developed. The objectives of the present work were to provide recommendations for the optimal extraction conditions and to investigate the effects of any extraction parameters on flavonoid yields from the I. javanica flower. The extraction process was performed using deep eutectic solvent (DES) (choline chloride and propylene glycol at molar ratio of 1 : 1) and the ultrasound-assisted extraction method. Both single-factor and response surface analyses using three-level and three-factor Box Behnken designs were conducted to obtain the optimum flavonoid concentrations. The results showed that the optimum extraction conditions for total flavonoids featured an extraction time of 40 min, 25% water content in DES and a solid-to-liquid ratio of 1 : 25 g ml −1 . An extract obtained under optimum extraction conditions showed higher total flavonoid yields than an ethanolic extract which was used for comparison. Scanning electron microscope images demonstrated that both of the solvents also showed different effects on the outer surface of the I. javanica flower during the extraction process. In summary, our work succeeded in determining the optimum conditions for total flavonoids in the I. javanica flower using a green extraction method.

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Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables

Cited by 52 publications

References 36 publications

Ultrasound-Assisted Extraction of Anthocyanins Using Natural Deep Eutectic Solvents and Their Incorporation in Edible Films

Ultrasound-Assisted Extraction of Anthocyanins Using Natural Deep Eutectic Solvents and Their Incorporation in Edible Films

Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.

A green extraction design for enhancing flavonoid compounds from Ixora javanica flowers using a deep eutectic solvent

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