Application of Cell Therapy for Anti-Aging Facial Skin

Zarei, Farshad; Abbaszadeh, Abolfazl

doi:10.2174/1574888x13666181113113415

Cited by 38 publications

(22 citation statements)

References 51 publications

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“…Some evidence indicates that early expansion of MSCs is related to their stemness profile, while long-term expanded MSCs are stromal cells associated with a senescent phenotype [ 188 , 189 ]. Recent studies report increasing proliferation induced by younger MSC-derived secretome, probably due to the secretion of rejuvenating growth factors such as GDF11 [ 190 , 191 ]. Interestingly, other studies have suggested that the secretome of senescent MSCs has a biological effect on their microenvironment [ 103 , 189 , 192 , 193 ].…”

Section: Exosome Manufacturing Status and Challengesmentioning

confidence: 99%

Exosome: A New Player in Translational Nanomedicine

Aheget

Tristán‐Manzano

Mazini

et al. 2020

JCM

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Summary: Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions have been attributed to exosomes: their capacity to transport proteins, lipids and nucleic acids between cells and organs, as well as their potential to act as natural intercellular communicators in normal biological processes and in pathologies. From a clinical perspective, the majority of applications use exosomes as biomarkers of disease. A new approach uses exosomes as biologically active carriers to provide a platform for the enhanced delivery of cargo in vivo. One of the major limitations in developing exosome-based therapies is the difficulty of producing sufficient amounts of safe and efficient exosomes. The identification of potential proteins involved in exosome biogenesis is expected to directly cause a deliberate increase in exosome production. In this review, we summarize the current state of knowledge regarding exosomes, with particular emphasis on their structural features, biosynthesis pathways, production techniques and potential clinical applications.

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Section: Exosome Manufacturing Status and Challengesmentioning

confidence: 99%

Exosome: A New Player in Translational Nanomedicine

Aheget

Tristán‐Manzano

Mazini

et al. 2020

JCM

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“…Besides, studies have demonstrated that ADSCs may have multiple clinical therapeutic applications, such as tissue regeneration, anti-wrinkle, tumors, and depigmentation. ADSCs are thought to be “immuno-privileged” and reliable in culturing for a long time [ 176 ], thereby exerting an outstanding advantage in dermatological field. In conclusion, these promising consequences showed that ADSCs might be potential cosmo-therapeutic tools addressing photoaging problem.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Application of adipose-derived stem cells in photoaging: basic science and literature review

Chen

2020

Stem Cell Res Ther

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Photoaging is mainly induced by continuous exposure to sun light, causing multiple unwanted skin characters and accelerating skin aging. Adipose-derived stem cells(ADSCs) are promising in supporting skin repair because of their significant antioxidant capacity and strong proliferation, differentiation, and migration ability, as well as their enriched secretome containing various growth factors and cytokines. The identification of the mechanisms by which ADSCs perform these functions for photoaging has great potential to explore therapeutic applications and combat skin aging. We also review the basic mechanisms of UV-induced skin aging and recent improvement in pre-clinical applications of ADSCs associated with photoaging. Results showed that ADSCs are potential to address photoaging problem and might treat skin cancer. Compared with ADSCs alone, the secretome-based approaches and different preconditionings of ADSCs are more promising to overcome the current limitations and enhance the anti-photoaging capacity.

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“…UV can react with water molecules in the skin to produce reactive oxygen species (ROS) that cause cell apoptosis and gene mutations through oxidative damage to lipids, proteins, and DNA [5][6][7]. Up to date, many efforts have been made to apply stem cells to the development of novel therapeutic strategies to achieve skin regeneration and repair [8,9]. However, there are various challenges such as low engraftment rate of transplanted cells, and uncontrollable proliferation and differentiation of cells, etc.…”

Section: Introductionmentioning

confidence: 99%

The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells

Han

Kim

et al. 2022

Pharmaceutics

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In this study, we examined the potentially beneficial effects of bovine colostrum-derived exosomes on UV-induced aging and damage in three major resident skin cells including keratinocytes, melanocytes, and fibroblasts. The treatment with colostrum exosomes prevented the UV-induced generation of intracellular reactive oxygen species in epidermal keratinocytes. In UV-stimulated melanocytes, colostrum exosomes could also significantly reduce the production of the protective skin-darkening pigment melanin, which may help to reduce the risk of excessive melanin formation causing skin hyperpigmentation disorders. In the human dermal fibroblasts treated with colostrum exosomes, the expression of matrix metalloproteinases was suppressed, whereas increased cell proliferation was accompanied by enhanced production of collagen, a major extracellular matrix component of skin. Taken together, our findings indicate that bovine colostrum-derived exosomes having excellent structural and functional stability offer great potential as natural therapeutic agents to repair UV-irradiated skin aging and damage.

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Application of Cell Therapy for Anti-Aging Facial Skin

Cited by 38 publications

References 51 publications

Exosome: A New Player in Translational Nanomedicine

Exosome: A New Player in Translational Nanomedicine

Application of adipose-derived stem cells in photoaging: basic science and literature review

The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells

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