Application of adipose-derived stem cells in photoaging: basic science and literature review

Chen, Shidie; He, Zhigang; Xu, Jinghong

doi:10.1186/s13287-020-01994-z

Cited by 40 publications

(43 citation statements)

References 173 publications

(174 reference statements)

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“…Several findings have shown that F-GRF and related AD-MSCs/SVF are effective in treating soft tissue defects and wrinkles [ 11 , 20 , 21 , 22 , 23 ], and previous studies have emphasized their application in wound healing (WH), scars treatment (ST), and also in the treatment of radiotherapy damage [ 24 ]. Thanks to the therapeutic effects of AD-MSCs and SVF in WH and ST, great attention has been paid to utilizing AD-MSCs in the treatment of photoaging damage.…”

Section: The Protective Role Of Ad-mscs In Skin Photoaging: In Vitro and In Vivo Analysismentioning

confidence: 99%

Adipose-Derived Mesenchymal Stem Cells (AD-MSCs) against Ultraviolet (UV) Radiation Effects and the Skin Photoaging

Gentile

Garcovich

2021

Biomedicines

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The skin is a natural barrier against the ultraviolet (UV) radiation of sunlight. The long-term and/or repetitive exposure to the sunlight and related UV radiation may change the skin structure, decreasing collagen production, promoting premature skin aging, which is termed “photoaging”. The signs of photoaging include wrinkle formation, mottled pigmentation, and/or cancerous changes. For many years, adipose-derived mesenchymal stem cells (AD-MSCs) and fat grafting (F-GRF) have been used to combat photoaging signs, wrinkles, loss of elasticity, and face soft tissue defects. Several studies have analyzed in vitro actions of AD-MSCs against photoaging’s effects, thanks to their migratory activity, paracrine actions, and related in vivo–ex vivo outcomes. In fact, AD-MSCs act against skin photoaging in vitro via activation of dermal fibroblast proliferation, antioxidant effect, and matrix metalloproteinases (MMPs) reduction. In vivo and ex vivo outcomes regard the local injection of AD-MSCs, F-GRF, and/or enriched-F-GRF with AD-MSCs directly in the wrinkles and the face’s soft tissue defects. This concise review summarizes the most recent in vitro, in vivo and ex vivo outcomes and developments on the effects of AD-MSCs and F-GRF against photoaging.

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Section: The Protective Role Of Ad-mscs In Skin Photoaging: In Vitro and In Vivo Analysismentioning

confidence: 99%

Adipose-Derived Mesenchymal Stem Cells (AD-MSCs) against Ultraviolet (UV) Radiation Effects and the Skin Photoaging

Gentile

Garcovich

2021

Biomedicines

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“…Pajanan radiasi ultraviolet dari matahari merupakan faktor utama penuaan ekstrinsik sehingga disebut photo aging yang mengacu pada efek pajanan sinar ultraviolet dalam waktu lama. 3 Pada penuaan ekstrinsik lapisan epidermis menebal, sedangkan pada penuaan intrinsik, lapisan epidermis menipis. Stratum korneum menebal karena kegagalan degradasi korneosit dari desmosom.…”

Section: Penuaan Ekstrinsikunclassified

Mekanisme Penuaan Kulit sebagai Dasar Pencegahan dan Pengobatan Kulit Menua

Yusharyahya¹

2021

ejki

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Seiring dengan meningkatnya populasi geriatri di Indonesia, masalah penuaan kulit juga turut meningkat. Pada populasi tersebut terjadi berbagai perubahan kulit sehingga kelainan yang ditimbulkan juga berbeda. Stres oksidatif merupakan mekanisme yang diduga kuat sebagai penyebab utama penuaan kulit. Penuaan kulit merupakan proses kompleks yang melibatkan faktor intrinsik dan ekstrinsik. Faktor intrinsik yang berperan adalah genetik, metabolisme sel, dan perubahan hormonal. Selain itu, terdapat faktor ekstrinsik seperti radiasi ultraviolet, inframerah, dan karsinogen lingkungan yang turut berperan pada penuaan kulit. Kedua faktor tersebut menyebabkan perubahan di seluruh lapisan kulit. Untuk mengatasi penuaan kulit, kini telah tersedia berbagai modalitas terapi, namun untuk menentukan terapi yang paling sesuai perlu diketahui fisiologi kulit menua, mekanisme penuaan kulit, dan manifestasi kelainan klinis kulit menua. Secara fisiologi terjadi perubahan permeabilitas, biokimia, vaskularisasi, termoregulasi, respons terhadap iritan, respons imunitas, kapasitas regenerasi, respons terhadap cedera, persepsi neurosensori dan pada tingkat genom. Jumlah sel epidermal dan laju pergantian epidermal menurun sedangkan di adneksa terjadi penurunan jumlah kelenjar sebasea yang mengakibatkan kulit kering dan mudah pecah. Penurunan jumlah melanosit menyebabkan warna rambut menjadi abu-abu keputihan dan muncul pigmentasi atipik di kulit. Folikel rambut kurang aktif sehingga meningkatkan kerontokan dan kebotakan. Di lapisan basal ukuran sel berkurang dan rerata ukuran sel bertambah. Sel keratinosit menjadi lebih pendek dan besar di kulit yang menua. Kata kunci: geriatri, mekanisme penuaan kulit, patofisiologi. Skin Aging Mechanism as A Basic Prevention and Treatment of Skin Aging Abstract Growing geriatric population generates a rise of aging issues. Process of aging develops multiple skin changes that further emerge other related skin problems. Oxidative stress is believed playing vital role related to aging. The aging process in the skin is complex and influenced by intrinsic and extrinsic factors. Intrinsic factors can be in the form of genetics, cell metabolism, and hormonal changes. Meanwhile, for extrinsic factors, such as exposure to ultraviolet, infrared, and carcinogenic agent also have crucial part in aging process. These factors contribute to all layers of the skin. Nowadays, many treatment modalities available to reverse skin aging, however, better understanding on skin aging mechanism, the pathophysiology, and clinical manifestations of aging skin is important to choose the appropriate treatment for patients. In aging, there are physiological changes in permeability, biochemical structures, vascularisation, thermoregulation, irritative response, immunity response, regenerative capability, inflammatory response, neurosensory perception and in genom level. The number of epidermal cells and epidermal overturn rate decline while there is also reduction of sebaseous glands at adnexa which both are accounted for skin xerosis. Decreasing melanocytes can caused gray hair and atypical pigmentation. Hair follicles also show less activity resulting in hair loss. Basal layer cells are downsizing and rise of average cells size are occured. Keratinocyte becomes shorter and bigger in aging skin. Keywords: geriatric, mechanism, skin aging, pathophysiology.

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“…In several reports, stem cell therapy has been proven to accelerate skin repair and the wound healing process. Out of all stem cell agents, ADSCs are the most commonly used stem cell therapeutics, and their use in tissue regeneration and skin rejuvenation has been extensively studied [97,98]. Although ADSCs' ability to multi-differentiate contributes to their therapeutic efficacy, paracrine effects of ADSCs are noted as the key mechanisms in tissue repair by modulating the local microenvironment.…”

Section: Theranostic/cosmetic Applications Of Extracellular Vesicles For Skin Agingmentioning

confidence: 99%

Extracellular Vesicles as Potential Theranostic Platforms for Skin Diseases and Aging

et al. 2021

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Extracellular vesicles (EVs), naturally secreted by cells, act as mediators for communication between cells. They are transported to the recipient cells along with cargoes such as nucleic acids, proteins, and lipids that reflect the changes occurring within the parent cells. Thus, EVs have been recognized as potential theranostic agents for diagnosis, treatment, and prognosis. In particular, the evidence accumulated to date suggests an important role of EVs in the initiation and progression of skin aging and various skin diseases, including psoriasis, systemic lupus erythematosus, vitiligo, and chronic wounds. This review highlights recent research that investigates the role of EVs and their potential as biomarkers and therapeutic agents for skin diseases and aging.

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Application of adipose-derived stem cells in photoaging: basic science and literature review

Cited by 40 publications

References 173 publications

Adipose-Derived Mesenchymal Stem Cells (AD-MSCs) against Ultraviolet (UV) Radiation Effects and the Skin Photoaging

Adipose-Derived Mesenchymal Stem Cells (AD-MSCs) against Ultraviolet (UV) Radiation Effects and the Skin Photoaging

Mekanisme Penuaan Kulit sebagai Dasar Pencegahan dan Pengobatan Kulit Menua

Extracellular Vesicles as Potential Theranostic Platforms for Skin Diseases and Aging

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