Application of capsaicin as a potential new therapeutic drug in human cancers

Zhang, Shengping; Wang, Dian; Huang, Jingying; Hu, Yueming; Xu, Yafei

doi:10.1111/jcpt.13039

Cited by 90 publications

(69 citation statements)

References 109 publications

(175 reference statements)

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“…Capsaicin (Figure 4), an active element of chili peppers, exhibited strong anticancer properties in diverse cancer types [227][228][229]. Capsaicin also hindered IL6-induced STAT3 activation.…”

Section: Capsaicinmentioning

confidence: 99%

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Bose¹,

Banerjee²,

Mondal³

et al. 2020

Cells

128

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Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway promotes tumorigenesis. Natural agents, including phytochemicals, exhibit potent anticancer activities via various mechanisms. However, the therapeutic potency of phytoconstituents as inhibitors of JAK/STAT signaling against cancer has only come into focus in recent days. The current review highlights phytochemicals that can suppress the JAK/STAT pathway in order to impede cancer cell growth. Various databases, such as PubMed, ScienceDirect, Web of Science, SpringerLink, Scopus, and Google Scholar, were searched using relevant keywords. Once the authors were in agreement regarding the suitability of a study, a full-length form of the relevant article was obtained, and the information was gathered and cited. All the complete articles that were incorporated after the literature collection rejection criteria were applied were perused in-depth and material was extracted based on the importance, relevance, and advancement of the apprehending of the JAK/STAT pathway and their relation to phytochemicals. Based on the critical and comprehensive analysis of literature presented in this review, phytochemicals from diverse plant origins exert therapeutic and cancer preventive effects, at least in part, through regulation of the JAK/STAT pathway. Nevertheless, more preclinical and clinical research is necessary to completely comprehend the capability of modulating JAK/STAT signaling to achieve efficient cancer control and treatment.

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Section: Capsaicinmentioning

confidence: 99%

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Bose¹,

Banerjee²,

Mondal³

et al. 2020

Cells

128

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show abstract

“…Among the mineral constituents, Fe, Ca, K, Mg, P, S, Na, and Se can be found. Capsaicin or the extract of chilli fruits was reported to have antidiabetic, anticancer, antiulcer, anticoagulant, analgesic, antiarthritic activities, as well as immunomodulatory, cardiovascular, pain-relief effects and memory enhancing, respiratory, hepatoprotective, anthelmintic, antifungal and antiviral activity [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Open‐tubular capillary electrochromatographic application of a sol‐gel matrix with chilli peppers, garlic, or synthetic additives

Svobodová

Mikšı́k

2020

J of Separation Science

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This article describes a possible combination of two promising fields of analytical chemistry—the preparation of sol‐gel matrices with varying additives and their application in capillary electrochromatography. The inner surfaces of capillaries were coated with the sol‐gel solution containing either pure synthetic chemical additive—alliin or capsaicin—or an extract of their natural sources—garlic and chilli pepper, respectively. The modified capillaries were tested for interaction with two neurotransmitters, oligopeptides and nucleotides under conditions of open‐tubular capillary electrochromatography. Because both of the natural extracts also contain vitamin C and saccharose, the capillaries with sol‐gel modifiers containing each of these substances were also tested. The obtained results from the perspective of changes in the electrochromatograms and the effective mobilities of analytes are discussed with respect to mild conditions both in the preparation process of the sol‐gel matrix and during the separations.

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“…Unfortunately, despite the progress in medicine and science, the number of cancer cases is constantly growing, which is mainly explained by lifestyle and living conditions, the increase in the number of populations and, to some extent, the reduction in the incidence of other common diseases. On the one hand, the research related to the development of diagnostics and treatment of cancer diseases focuses on developing more effective methods of administering commercially available drugs to the patient, on the other, on the searching for new compounds with anticancer properties [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. The process of searching for new cancer compounds with strong activity while maintaining low general toxicity (towards healthy tissues) and determining the mechanism of their action is long and complex.…”

Section: Introductionmentioning

confidence: 99%

Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix

Kowalczyk

Kasprzak

Popławska

et al. 2020

IJMS

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This work presents a new look at the application of cyclodextrins (CD) as a drug nanocarrier. Two different cyclodextrins (αCD, βCD) were covalently conjugated to branched polyethylenimine (PEI), which was additionally functionalized with folic acid (PEI-βCD-αCD-FA). Here, we demonstrated that the combination of αCD and βCD enabled to load and control release of two anticancer drugs: doxorubicin (DOX) and beta-lapachone (beta-LP) (DOX in β-CD and beta-LP into α-CD) via host-guest inclusion. The PEI-βCD(DOX)-αCD-FA nanoconjugate was used to transport anticancer drugs into A549 lung cancer cells for estimation the cytotoxic and antitumor effect of this nanoconjugate. The presence of FA molecules should facilitate the penetration of studied nanoconjugate into the cell. Whereas, the non-cellular experiments proved that the drugs are released from the carrier mainly in the pH 4.0. The release mechanism is found to be anomalous in all studied cases.

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Application of capsaicin as a potential new therapeutic drug in human cancers

Cited by 90 publications

References 109 publications

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Open‐tubular capillary electrochromatographic application of a sol‐gel matrix with chilli peppers, garlic, or synthetic additives

Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix

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