Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix

Kowalczyk, Agata; Kasprzak, Artur; Popławska, Magdalena; Ruzycka-Ayoush, Monika; Grudziński, Ireneusz P.; Nowicka, Anna M.

doi:10.3390/ijms21165832

Cited by 6 publications

(10 citation statements)

References 54 publications

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“…There are special phenomena such as color changes in the merging processes and the particularity of red-shift and bonding formations. When added DOX, the color changed from orange-red to blue-purple, and the UV absorption peak of the Au-Ag cluster @PEI-DOX shifted from 480 nm to 580 nm, which was due to the formation of hydrogen bond between the carbonyl group of DOX (as hydrogen acceptor) and the -NH 2 group of PEI (hydrogen donor) [ 60 ]. Amino groups interacted rapidly with the carbonyl groups on DOX to form hydrogen bonds in aqueous solution, and its morphological features can be seen in the TEM images as a striated structure with the appearance of a lattice ( Figure S5b,c ).…”

Section: Resultsmentioning

confidence: 99%

Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability

Yang

et al. 2022

IJMS

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In this work, we firstly report the preparation of heterogeneously assembled structures Au-Ag nanoclusters (NCs) as good drug carriers with high loading performance and biocompatible capability. As glutathione-protected Au and Ag clusters self-assembled into porous Au-Ag NCs, the size value is about 1.358 (±0.05) nm. The morphology characterization revealed that the diameter of Au-Ag NCs is approximately 120 nm, as well as the corresponding potential ability in loading performance of the metal cluster triggered-assembling process. Compared with individual components, the stability and loading performance of heterogeneous Au-Ag NCs were improved and exhibit that the relative biocompatibility was enhanced. The exact information about this is that cell viability was approximately to 98% when cells were incubated with 100 µg mL−1 particle solution for 3 days. The drug release of Adriamycin from Au-Ag NCs was carried out in PBS at pH = 7.4 and 5.8, respectively. By simulating in vivo and tumor microenvironment, the release efficiency could reach over 65% at pH = 5.8 but less than 30% at pH = 7.2. Using an ultrasound field as external environment can accelerate the assembling process while metal clusters triggered assembling Au-Ag NCs. The size and morphology of the assembled Au-Ag NCs can be controlled by using different power parameters (8 W, 13 W, 18 W) under ambient atmosphere. Overall, a novel approach is exhibited, which conveys assembling work for metal clusters triggers into heterogeneous structures with porous characteristic. Its existing properties such as water-solubility, stability, low toxicity and capsulation can be considered as dependable agents in various biomedical applications and drug carriers in immunotherapies.

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Section: Resultsmentioning

confidence: 99%

Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability

Yang

et al. 2022

IJMS

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“…A diverse number of carriers of chemotherapy agents have been reported that have pH-sensitive non-covalent interactions. These non-covalent bonds have been found between chemotherapy agents and carriers, including DNA, cyclodextrin, and carbon dots [ 97 , 98 , 99 , 100 ]. These bonds are primarily ionic but include supporting roles from hydrogen and hydrophobic bonds [ 101 ].…”

Section: Ph-sensitive Bondsmentioning

confidence: 99%

Delivery of Chemotherapy Agents and Nucleic Acids with pH-Dependent Nanoparticles

et al. 2023

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With less than one percent of systemically injected nanoparticles accumulating in tumors, several novel approaches have been spurred to direct and release the therapy in or near tumors. One such approach depends on the acidic pH of the extracellular matrix and endosomes of the tumor. With an average pH of 6.8, the extracellular tumor matrix provides a gradient for pH-responsive particles to accumulate, enabling greater specificity. Upon uptake by tumor cells, nanoparticles are further exposed to lower pHs, reaching a pH of 5 in late endosomes. Based on these two acidic environments in the tumor, various pH-dependent targeting strategies have been employed to release chemotherapy or the combination of chemotherapy and nucleic acids from macromolecules such as the keratin protein or polymeric nanoparticles. We will review these release strategies, including pH-sensitive linkages between the carrier and hydrophobic chemotherapy agent, the protonation and disruption of polymeric nanoparticles, an amalgam of these first two approaches, and the release of polymers shielding drug-loaded nanoparticles. While several pH-sensitive strategies have demonstrated marked antitumor efficacy in preclinical trials, many studies are early in their development with several obstacles that may limit their clinical use.

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“…Hydroxyl groups of CyDs that aligned on the surface of truncated cone are important in grafting with other functional molecules. The CyDs were modified by several typical chemical reactions (such as amination, halogenation, esterification, and sulfonation) and introduce amine, halogen, alkoxy and sulfite groups that can be further modified or self-assembled [6,92,102]. Therefore, the intrinsic ability of CyD allows the synthesis of a series of self-assembled supramolecular structures with different functions via noncovalent interactions.…”

Section: Self-assemble Capabilitymentioning

confidence: 99%

“…However, the amphiphilic part could interact with both surrounding solution molecule and hydrophobic part. A very extensively studied self-assembly process is the self-assembly of block or graft copolymers, where incompatible polymer chains are bonded covalently [102]. This part can be systematically acknowledged from elsewhere [2,31,103,104].…”

Section: Self-assembly Directed By Hydrophilic-hydrophobic Interactionsmentioning

confidence: 99%

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

Chen¹,

Zheng²,

Tian³

et al. 2023

Preprint

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Drug delivery systems consist of cyclodextrins (CyDs) have kept constant attention for good compatibility, negligible toxicity, and improved pharmacokinetics of drugs. The unique hollow structure has endowed a lot of functions, such as inclusion of guest molecules, functional modification of active hydroxyl groups, and noncovalent interactions. Besides, the polyhydroxy structure has further extended the functions of CyDs by inter/intramolecular interactions and chemical modification. Furthermore, the versatile functions of the complex contribute to physicochemical characteristics alteration of the drugs, therapeutic talent, stimulus-responsive switch, self-assemble capability, and fiber formation. This review attempts to list the recent progress of CyDs and discuss their roles in the drug delivery system. Future perspectives of the construction of CyD-based drug delivery systems are also discussed at the end of this review, which may be the possible directions for the construction of more rational and cost-effective delivery vehicles.

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Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix

Cited by 6 publications

References 54 publications

Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability

Metal Cluster Triggered-Assembling Heterogeneous Au-Ag Nanoclusters with Highly Loading Performance and Biocompatible Capability

Delivery of Chemotherapy Agents and Nucleic Acids with pH-Dependent Nanoparticles

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

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