Application of 3D printing technology in bone tissue engineering

Ji, Kang; Wang, Yanen; Wei, Qinghua; Zhang, Kun; Jiang, Anguo; Rao, Yiwen; Cai, Xianxuan

doi:10.1007/s42242-018-0021-2

Cited by 57 publications

(26 citation statements)

References 49 publications

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“…This significantly decreases printing time (Wang Z. et al, 2015). Also, external geometry and internal architecture of the scaffold can be precisely controlled by SLA due to a high resolution advantage of accuracy at 20 μm, due to the width of the light source being very small and highly controlled (Ji et al, 2018). Thus, the complex scaffold can be easily fabricated.…”

Section: D Printingmentioning

confidence: 99%

3D and 4D Printing of Polymers for Tissue Engineering Applications

Tamay

Usal

Alagoz

et al. 2019

Front. Bioeng. Biotechnol.

302

239

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Three-dimensional (3D) and Four-dimensional (4D) printing emerged as the next generation of fabrication techniques, spanning across various research areas, such as engineering, chemistry, biology, computer science, and materials science. Three-dimensional printing enables the fabrication of complex forms with high precision, through a layer-by-layer addition of different materials. Use of intelligent materials which change shape or color, produce an electrical current, become bioactive, or perform an intended function in response to an external stimulus, paves the way for the production of dynamic 3D structures, which is now called 4D printing. 3D and 4D printing techniques have great potential in the production of scaffolds to be applied in tissue engineering, especially in constructing patient specific scaffolds. Furthermore, physical and chemical guidance cues can be printed with these methods to improve the extent and rate of targeted tissue regeneration. This review presents a comprehensive survey of 3D and 4D printing methods, and the advantage of their use in tissue regeneration over other scaffold production approaches.

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Section: D Printingmentioning

confidence: 99%

3D and 4D Printing of Polymers for Tissue Engineering Applications

Tamay

Usal

Alagoz

et al. 2019

Front. Bioeng. Biotechnol.

302

239

View full text Add to dashboard Cite

show abstract

“…SLA produces 3D models by tracing a beam of UV light or a laser on a base of a photosensitive resin that polymerizes (Mondschein et al, 2017). The main benefit of this 3D printing technology is the high level of detail and the excellent surface resolution (Ji et al, 2018).…”

Section: D Printing Techniques and Production Of Personalized Surgicmentioning

confidence: 99%

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Vidal

Kampleitner

Brennan

et al. 2020

Front. Bioeng. Biotechnol.

125

108

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The healing of bone fractures is a well-orchestrated physiological process involving multiple cell types and signaling molecules interacting at the fracture site to replace and repair bone tissue without scar formation. However, when the lesion is too large, normal healing is compromised. These so-called non-union bone fractures, mostly arising due to trauma, tumor resection or disease, represent a major therapeutic challenge for orthopedic and reconstructive surgeons. In this review, we firstly present the current commonly employed surgical strategies comprising auto-, allo-, and xenograft transplantations, as well as synthetic biomaterials. Further to this, we discuss the multiple factors influencing the effectiveness of the reconstructive therapy. One essential parameter is adequate vascularization that ensures the vitality of the bone grafts thereby supporting the regeneration process, however deficient vascularization presents a frequently encountered problem in current management strategies. To address this challenge, vascularized bone grafts, including free or pedicled fibula flaps, or in situ approaches using the Masquelet induced membrane, or the patient's body as a bioreactor, comprise feasible alternatives. Finally, we highlight future directions and novel strategies such as 3D printing and bioprinting which could overcome some of the current challenges in the field of bone defect reconstruction, with the benefit of fabricating personalized and vascularized scaffolds.

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“…Ink-based technologies include IJP [153], and aerosol jet printing (AJP) [154]. Comprehensive descriptions of these technologies can be found in [2,[155][156][157], to name a few. However, the operation mechanisms of these techniques and their advantages and limitations are briefly described here.…”

Section: D Printing Technologies Based On Stimulation Usedmentioning

confidence: 99%

“…However, they have a number of shortcomings including the limited sources and donor site morbidity. Allografts also have the risk of immune rejection and disease transmission [ 2 , 3 ]. Therefore, the research has headed for other solutions via tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Challenges on optimization of 3D-printed bone scaffolds

Bahraminasab

2020

BioMed Eng OnLine

134

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Background Bones in human body are prone to damage due to different causes such as fractures, diseases, and infections. Nevertheless, they have a remarkable capacity to repair and heal themselves after trauma and illness. Large defects, however, are never completely reinstated because their sizes are beyond the limit up to which the bones can repair [1]. In these conditions, therefore, a medical remedy is required to stabilize, align and support the damaged bone region to restore the lost function. Bone autografts are considered the gold standard treatment. However, they have a number of shortcomings including the limited sources and donor site morbidity. Allografts also have the risk of immune rejection and disease transmission [2, 3]. Therefore, the research has headed for other solutions via tissue engineering. Bone tissue engineering provides three-dimensional (3D)

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Application of 3D printing technology in bone tissue engineering

Cited by 57 publications

References 49 publications

3D and 4D Printing of Polymers for Tissue Engineering Applications

3D and 4D Printing of Polymers for Tissue Engineering Applications

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Challenges on optimization of 3D-printed bone scaffolds

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