3D and 4D Printing of Polymers for Tissue Engineering Applications

Tamay, Dilara Goksu; Usal, Tugba Dursun; Alagoz, Ayse Selcen; Yücel, Deniz; Hasırcı, Nesrin

doi:10.3389/fbioe.2019.00164

Cited by 316 publications

(264 citation statements)

References 199 publications

(228 reference statements)

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“…Three-dimensional (3D) printing is a promising technique for fabricating implantable hydrogels for various biomedical applications [24,[26][27][28][29]. These types of hydrogels have been reported in the literature as a potential scaffold for post-surgery applications in in vivo experiments [30,31]. However, there are just few numbers of these printable scaffolds, like poly-lactic acid (PLA) hydrogels, which are approved by FDA.…”

Section: Implantable Hydrogelsmentioning

confidence: 99%

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Askari

Seyfoori

Amereh

et al. 2020

Gels

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Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.

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Section: Implantable Hydrogelsmentioning

confidence: 99%

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Askari

Seyfoori

Amereh

et al. 2020

Gels

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“…The most critical part of 4D printing is the material, rather than printing technology. The material bottleneck is the main challenge of 4D printing (Lui et al, 2019; Tamay et al, 2019). The material used in 4D printing is required to be able to undergo favorable changes in deformation excitation conditions (such as temperature, humidity, electric field, magnetic field, pH, etc.)…”

Section: From 3d Printing To Four‐dimensional Printingmentioning

confidence: 99%

Three‐dimensional printing: The potential technology widely used in medical fields

Fan

Zhu

2020

J Biomedical Materials Res

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Three‐dimensional (3D) printing technology is one of the hottest research fields nowadays, which has influenced the treatment methods in the medical industry. In order to explore the progress of 3D printing technology in medical applications, the authors conducted English retrieval with the keywords “three‐dimensionalprinting,” “bioprinting,” and “3D printing” in PubMed, and extracted information related to this exploration. This review firstly introduces the 3D printing materials, types of technology, and printing procedures in medical fields, then elaborates the current applications of 3D printing in medical devices, in vitro anatomical models, organ printing, implants, tissue engineering scaffolds, and the leap from 3D medical printing to four‐dimensional (4D) medical printing, finally put forward the shortage of the medical 3D/4D printing and possible solutions of them.

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“…Stereolithography is a 3D printing technique based on the layer photopolymerization of specific materials by means of light irradiation, usually UV, leading to a final stacked scaffold as the build stage is vertically translated. This fabrication method is characterized by an intrinsic high resolution, the highest among all the additive manufacturing techniques (about 6 μm), which allows finely controlling external geometry and internal architecture of the designed scaffold to realize complex geometries [ 30 ]. In addition, a reliable modification can be further considered to include additional functional cues [ 31 ].…”

Section: Moving Towards Biomimetic Engineered Muscular Constructsmentioning

confidence: 99%

Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds

Baiguera

Gaudio²,

Carotenuto

et al. 2020

Nanomaterials

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Severe muscle injuries are a real clinical issue that still needs to be successfully addressed. Tissue engineering can represent a potential approach for this aim, but effective healing solutions have not been developed yet. In this regard, novel experimental protocols tailored to a biomimetic approach can thus be defined by properly systematizing the findings acquired so far in the biomaterials and scaffold manufacturing fields. In order to plan a more comprehensive strategy, the extracellular matrix (ECM), with its properties stimulating neomyogenesis and vascularization, should be considered as a valuable biomaterial to be used to fabricate the tissue-specific three-dimensional structure of interest. The skeletal muscle decellularized ECM can be processed and printed, e.g., by means of stereolithography, to prepare bioactive and biomimetic 3D scaffolds, including both biochemical and topographical features specifically oriented to skeletal muscle regenerative applications. This paper aims to focus on the skeletal muscle tissue engineering sector, suggesting a possible approach to develop instructive scaffolds for a guided healing process.

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3D and 4D Printing of Polymers for Tissue Engineering Applications

Cited by 316 publications

References 199 publications

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Three‐dimensional printing: The potential technology widely used in medical fields

Information-Driven Design as a Potential Approach for 3D Printing of Skeletal Muscle Biomimetic Scaffolds

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