Apitherapeutics and phage-loaded Nanofibers As Wound Dressings With Enhanced Wound Healing and Antibacterial Activity

Sarhan, Wessam A.; Azzazy, Hassan M. E.

doi:10.2217/nnm-2017-0151

Cited by 56 publications

(32 citation statements)

References 36 publications

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“…In one study propolis and other honey products were loaded into chitosan nanofibers and tested against multidrug-resistant Pseudomonas aeruginosa. Results demonstrated great biocompatibility, potent antibacterial activity and enhanced wound-healing properties, suggesting their potential use in wound-healing dressings (Sarhan and Azzazy, 2017 ). Propolis extracts contain a wide variety of chemical components including a high content of polyphenols, especially flavonoids which include quercetin, pinocembrin, formononetin, and coumaric acid.…”

Section: Propolismentioning

confidence: 99%

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

et al. 2018

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Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural balance toward a pro-oxidative state, resulting in oxidative stress. The detrimental effects of oxidative stress occur through multiple mechanisms that involve alterations to proteins and lipids, induction of inflammation, immunosuppression, DNA damage, and activation of signaling pathways that affect gene transcription, cell cycle, proliferation, and apoptosis. All of these alterations promote carcinogenesis and therefore, regulation of ROS levels is critical to the maintenance of normal skin homeostasis. Several botanical products have been found to exhibit potent antioxidant capacity and the ability to counteract UV-induced insults to the skin. These natural products exert their beneficial effects through multiple pathways, including some known to be negatively affected by solar UVR. Aging of the skin is also accelerated by UVR exposure, in particular UVA rays that penetrate deep into the epidermis and the dermis where it causes the degradation of collagen and elastin fibers via oxidative stress and activation of matrix metalloproteinases (MMPs). Because natural compounds are capable of attenuating some of the UV-induced aging effects in the skin, increased attention has been generated in the area of cosmetic sciences. The focus of this review is to cover the most prominent phytoproducts with potential to mitigate the deleterious effects of solar UVR and suitability for use in topical application.

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Section: Propolismentioning

confidence: 99%

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

et al. 2018

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“…This novel green nanofibrous dressings showed significant antimicrobial activity against these pathogens, enhanced biocompatibility and wound healing activity, and represented a highly competitive wound dressing. 44 In another study, phage Lysins (PlyPa03 and PlyPa91) were used for the treatment of the CD1 mice model of P. aeruginosa skin infection. The results showed that these two phage lysins (100-µg/mL lysins in 30 mM HEPES buffer) can have an inhibitory effect on this bacterium, even in their stationary phase.…”

Section: Pseudomonas Aeruginosamentioning

confidence: 99%

<p>Bacteriophages, a New Therapeutic Solution for Inhibiting Multidrug-Resistant Bacteria Causing Wound Infection: Lesson from Animal Models and Clinical Trials</p>

Moghadam¹,

Khoshbayan²,

Chegini³

et al. 2020

DDDT

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Wound infection kills a large number of patients worldwide each year. Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa are the most important colonizing pathogens of wounds that, with various virulence factors and impaired immune system, causes extensive tissue damage and nonhealing wounds. Furthermore, the septicemia caused by these pathogens increases the mortality rate due to wound infections. Because of the prevalence of antibiotic resistance in recent years, the use of antibiotics to inhibit these pathogens has been restricted, and the topical application of antibiotics in wound infections increases antibiotic resistance. Therefore, finding a new therapeutic strategy against wound infections is so essential since these infections have a destructive effect on the patient's mental health and high medical costs. In this review, we discussed the use of phages for the prevention of multidrug-resistant (MDR) bacteria, causing wound infection and their role in wound healing in animal models and clinical trials. The results showed that phages have a high ability to inhibit different wound infections caused by MDR bacteria, heal the wound faster, have lower side effects and toxicity, destroy bacterial biofilm, and they are useful in controlling immune responses. Many studies have used animal models to evaluate the function of phages, and this study appears to have a positive impact on the use of phages in clinical practice and the development of a new therapeutic approach to control wound infections, although there are still many limitations.

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“…However, no significant synergistic activity in reducing the Salmonella count was observed among the three antimicrobials (Wang et al, 2017). Sarhan & Azzazy (2017) and honey alone and in combination was assessed by Oliveira et al (2017). Two Portuguese types of honey with different floral origins and a specific E. coli phage (EC3a) were tested against 24 h and 48 h biofilms.…”

Section: Bacteriophages Associated With Natural Antibacterial Substancesmentioning

confidence: 99%

Bacteriophages’ action against mastitis-causing bactéria

Barbosa

Almada

Schmitz

et al. 2020

RSD

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Mastitis is a breast tissue disease with a high incidence in dairy cows and implications ranging from the health of the animals to the economy of the sector. Although antibiotic therapy is widely used, the search for new perspectives in the management and treatment of this disease is necessary. Although phage research preceded the discovery of antibiotics, with the appearance of antibiotics and their efficiency in treating infections, phage therapy fell into disuse. However, phage therapy has now re-emerged as an alternative for combating multidrug-resistant bacteria. The relationship between phages, bacteria, and the immune system is unique, generating a wide range of opportunities, some of which have yet to be studied. Thus, the objective of this review was to analyze the use of bacteriophages in the control of bovine mastitis and its association with other natural products today. Phages have been shown to exert effective antibacterial and anti-biofilm activity, and their interactions with other substances of natural origin could be a viable path for treating disease. Despite being little explored, phages are already being considered as an alternative for treatment against the main bacterial agents of mastitis. In this review, the safety and future pathways of phage therapy are addressed in order to indicate points where research still needs to progress and the main advantages and difficulties in this area.

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Apitherapeutics and phage-loaded Nanofibers As Wound Dressings With Enhanced Wound Healing and Antibacterial Activity

Abstract: The developed biocompatible nanofibers represent competitive wound-healing dressings with potent antibacterial and wound-healing activity.

Cited by 56 publications

References 36 publications

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

<p>Bacteriophages, a New Therapeutic Solution for Inhibiting Multidrug-Resistant Bacteria Causing Wound Infection: Lesson from Animal Models and Clinical Trials</p>

Bacteriophages’ action against mastitis-causing bactéria

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