Bacteriophages’ action against mastitis-causing bactéria

Abstract

Mastitis is a breast tissue disease with a high incidence in dairy cows and implications ranging from the health of the animals to the economy of the sector. Although antibiotic therapy is widely used, the search for new perspectives in the management and treatment of this disease is necessary. Although phage research preceded the discovery of antibiotics, with the appearance of antibiotics and their efficiency in treating infections, phage therapy fell into disuse. However, phage therapy has now re-emerged as an alternative for combating multidrug-resistant bacteria. The relationship between phages, bacteria, and the immune system is unique, generating a wide range of opportunities, some of which have yet to be studied. Thus, the objective of this review was to analyze the use of bacteriophages in the control of bovine mastitis and its association with other natural products today. Phages have been shown to exert effective antibacterial and anti-biofilm activity, and their interactions with other substances of natural origin could be a viable path for treating disease. Despite being little explored, phages are already being considered as an alternative for treatment against the main bacterial agents of mastitis. In this review, the safety and future pathways of phage therapy are addressed in order to indicate points where research still needs to progress and the main advantages and difficulties in this area.

Combating Bovine Mastitis in the Dairy Sector in an Era of Antimicrobial Resistance: Ethno-veterinary Medicinal Option as a Viable Alternative Approach

“…The goal of managing mastitis with antibiotics is to eradicate the pathogens from the cattle, or worse still, those from the udder. Antibiotics are often used to manage mastitis in lactating cows, as well as to prevent intramammary infections in non-lactating cows ( 4 , 5 ). More or less 60–70% of the antimicrobials used in cattle are for the prevention and treatment of mastitis ( 79 ).…”

Терапевтична Ефективність Бактеріофагового Препарату «фагомаст» Для Лікування Субклінічного Маститу Корів

“…У літературі трапляються дослідження, які вказують на те, що введення фагових препаратів шляхом інтрамамальної інфузії здатне викликати різку імунну відповідь, що проявляється збільшенням кількості соматичних клітин у молоці [21,22]. Тому ми визначили кількість соматичних клітин у секреті молочної залози корів при лікуванні фаговим препаратом «Фагомаст».…”

Óleo essencial de Lippia origanoides (Verbenaceae) na higienização de tetos de vacas leiteiras

“…A implantação de programas de controle para a mastite bovina estão relacionados com a redução dos fatores negativos que essa enfermidade provoca na cadeia produtiva do leite, sendo eles, queda na produção, menor rendimento dos produtos lácteos, diminuição do tempo de prateleira, aumento dos custos com medicamentos, honorários profissionais, descarte de leite durante o período de tratamento e carência, perda de tetos, e descarte de animais (Barbosa, et al, 2020).…”