Anxiolytic- and antidepressant-like effects of an ethanolic extract of the aerial parts of Hilleria latifolia (Lam.) H. Walt. in mice

Woode, Eric; Abotsi, Wonder Kofi Mensah; Mensah, Abraham Yeboah

doi:10.4103/2229-5119.83955

Cited by 10 publications

(3 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This pentacyclic triterpene has been widely consumed for many centuries without health hazard (Michael et al, 2007; Newman and Cragg, 2007). Studies have shown anxiolytic and antidepressant-like effects of isolated triterpenoids such as α amirin and β amirin (Chen et al, 2005; Rodrigues et al, 2002; Woode et al, 2011). However, being natural products, relative abundance of these triterpenoids varied from species to species.…”

Section: Introductionmentioning

confidence: 99%

Plurality of anxiety and depression alteration mechanism by oleanolic acid

et al. 2014

View full text Add to dashboard Cite

Our study sought to evaluate the anxiolytic and antidepressant activities of oleanolic acid as well as the neural mechanisms involved. Animal models such as barbiturate sleep-induction, light-dark box, elevated plus maze, forced swimming test, tail suspension test and open field test were conducted. Male Albino Swiss mice were treated orally with vehicle 10 mL/kg, fluoxetine 20 mg/kg, imipramine 15 mg/kg, diazepam 1 mg/kg or oleanolic acid 5-40 mg/kg. Pretreatment (intraperitoneal) of animals with pentylenetetrazole (PTZ) 20 mg/kg, 1-(2-methoxyphenyl)-4-[4- (2-phthalimido) butyl]piperazine hydrobromide (NAN-190) 0.5 mg/kg, p-chlorophenylalanine methyl ester (PCPA) 100 mg/kg or α-methyl-p-tyrosine (AMPT) 100 mg/kg, WAY100635 (WAY) 0.3 mg/kg, prazosin (PRAZ) 1 mg/kg, yohimbine 2 mg/kg as well as monoamine oxidase assay and hippocampal brain-derived neurotrophic factor (BDNF) quantification were carried out. Oleanolic acid potentiated the hypnotic effect of barbiturate and demonstrated an anxiolytic effect in both the light-dark box and elevated plus maze. This effect was not reversed by PTZ. Acute and/or chronic oral treatment of mice with oleanolic acid (5-20 mg/kg) elicited an antidepressant effect in the forced swimming test and the tail suspension test without interfering with the locomotor activity. The antidepressant effect of oleanolic acid was attenuated by NAN-190, AMPT, PCPA, WAY and PRAZ. Although monoamine oxidase activity remained unaltered by oleanolic acid, chronic administration of oleanolic acid augmented hippocampal BDNF level. These findings demonstrate multiple mechanisms of the anxiolytic and antidepressant effect of oleanolic acid.

show abstract

Section: Introductionmentioning

confidence: 99%

Plurality of anxiety and depression alteration mechanism by oleanolic acid

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Anxiety and depression are the most common psychiatric disorders; already cover 20% of the adult population, suffering from these illnesses at some time during their lives [2][3][4]. It has grown up to be an important area of research interest in psychopharmacology during this decade [5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Neuropharmacological Effects of Different Chemical Extracts ofFlemingia Stricta(Roxb.) Leaves

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Traditional preparation of the leaf of Flemingia stricta (Fabaceae) Roxb. , a medicinal plant of the Indian subcontinent, has been used for treatment of different diseases as herbal preparation. Our purpose was to analyze Neuropharmacological effects of different chemical extracts of Flemingia stricta Roxb. as particular form of behavioral inhibition that occurs in response to novel environmental events. Methods:In present study, the anxiogenic activity of crude extracts of Flemingia stricta leaves was determined using standard animal behavioral models, such as hole cross and open field; Sedative property and anxiolytic potential were assessed by conducting thiopental sodium induced sleeping times tests and elevated plus maze test respectively. Results:The crude extracts at both dose (200 and 400mg/kg) exhibited a significant (P<0.05, P<0.01) dose-dependent suppression of motor activity and exploratory activity of mice in both open field and hole cross test. In anxiolytic study, extracts displayed increased percentage of entry into open arm at the dose of 200 and 400mg/kg. Extracts produced a significant (P<0.05, P<0.01) increase in sleeping duration and reduction of onset of sleep compared to sodium thiopental at both doses (200 and 400mg/kg). Conclusion:This study demonstrates that the treated extracts have significant central nervous system depressant effect. Further studies on the active constituent of the extract can provide approaches for therapeutic intervention.

show abstract

“…Over 20% of the adult population suffers from these illnesses at some time during their lives [1][2][3] . It has become an important area of research interest in psychopharmacology during this decade [4] . Benzodiazepines are among the most prescribed and effective antianxiety drugs used worldwide [5].…”

Section: Introductionmentioning

confidence: 99%

Investigation of In-Vivo Neuropharmacological and In-Vitro Thrombolytic Activity & Phytochemical Analysis of Ethanolic Extract of Argyria Captiformis Leaves

Islam¹,

Karim²,

Hasan³

et al. 2015

AJBLS

View full text Add to dashboard Cite

Objectives: Investigation with the crude ethanolic extract of Argyria captiformis leaves was carried out to evaluateits possible thrombolysis and to analyze in -vivo neuro-pharmacological effects as anxiety is a particular form of behavioral inhibition that occurs in response to novel environment events and also phytochemical screening of plant extract. Method: Ethanolic extract of Argyria captiformis Leaves was assessed for sedative and anxiolytic activity on Swiss albino mice and Thrombolytic activity was assessed with human blood and also phytochemical screening test was done by various chemical reagents. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and anxiolytic property was evaluated by elevated-plus maze(EPM) tests at 400mg/kg while the peripheral and thrombolytic activity determined by percentage of clot lysis. Result: In anxiolytic study, the extract displayed increased percentage of entry into open arm at the dose of 400mg/kg. The extract produced a significant (P<0.01) increase in sleeping duration and reduction of onset of sleep compared to sodium thiopental at doses (400 mg/kg) .The extract (400 mg/kg) also showed suppression of motor activity and exploratory activity of the mice in both open field and hole cross test. Argyria captiformis alone & Argyria captiformis in combination with Streptokinase demonstrated 38.19±4.76% & 77.45±2.97% clot lysis effect respectively & revealed significant with comparison to both the control agent. The presence of tannins, glycosides, saponins, flavonoids, cardiac glycosides, and phytosterols was determined. Conclusion: The pharmacological profiles of the present investigation of the ethanol extract of A. captiformis indicate that the extract possess good CNS depressant and exhibited considerable thrombolytic as it significantly reduced locomotion, onset of sleep, increased duration of sleep and also presence of, glycosides, cardiac glycosides, saponins, flavonoids ,tannins and phytosterols.

show abstract

Anxiolytic- and antidepressant-like effects of an ethanolic extract of the aerial parts of Hilleria latifolia (Lam.) H. Walt. in mice

Cited by 10 publications

References 52 publications

Plurality of anxiety and depression alteration mechanism by oleanolic acid

Plurality of anxiety and depression alteration mechanism by oleanolic acid

Evaluation of Neuropharmacological Effects of Different Chemical Extracts ofFlemingia Stricta(Roxb.) Leaves

Investigation of In-Vivo Neuropharmacological and In-Vitro Thrombolytic Activity & Phytochemical Analysis of Ethanolic Extract of Argyria Captiformis Leaves

Contact Info

Product

Resources

About