Evaluation of Neuropharmacological Effects of Different Chemical Extracts of<i>Flemingia Stricta</i>(Roxb.) Leaves

Ms, Biozid; Mn, Alam; Mj, Abeden; Mm, Rahman; Mr, Islam

doi:10.1101/2020.04.09.034553

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…In recent years, there has been a growing belief that medicinal plants are a safer treatment option over synthetic drugs. This change has led to the increasing use of phytopharmaceuticals [19]. Caraway (Carum carvi L.) belongs to the umbellifers family and is native to Europe, Asia, and North Africa.…”

Section: Introductionmentioning

confidence: 99%

Caraway Oil as a Multimodal Therapy for Neuropathic Pain: Investigating the Mechanisms of Action in Rats with Chronic Constriction Injury

et al. 2023

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Neuropathic pain, a prevalent concern associated with various pathological conditions, poses a significant public health risk due to its poorly understood pathophysiology and treatment complexities. Multimodal therapy is often the most efficacious approach to managing neuropathic pain, yet it is also highly labour intensive. The exact underlying causes of neuropathic pain are unclear; evidence suggests that cytokines, neuropeptides, and neurotrophic factors may play a role in its pathogenesis. The current study aimed to investigate the anti-neuropathic pain activity of caraway oil and the molecular mechanisms underlying its actions in rats with CCI, a model of neuropathic pain. Behavioural evaluations of cold allodynia, heat hyperalgesia, mechanical allodynia, and mechanical hyperalgesia were conducted using the acetone spray test, hot plate test, Von Frey hair test, and pinprick test, respectively. Additionally, the level of TNF-α in the sciatic nerve was examined as an indicator of inflammation, and NGF and substance P levels were determined in the DRG to identify mechanistic processes. Rats were administered caraway oil orally at doses of 25 and 50 mg/kg for 21 days. Results indicated that caraway oil administration significantly reduced behaviour associated with injury-related pain and elevated TNF levels. After an anti-NGF injection on the 21st day, significant attenuated behavioural effects were observed. Furthermore, caraway oil administration was able to inhibit the upregulation of NGF in DRG caused by CCI and minimize the increase in substance P in DRG. These findings suggest that caraway oil has promising therapeutic potential for managing neuropathic pain by targeting peripheral and secondary sensitization mechanisms.

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Section: Introductionmentioning

confidence: 99%

Caraway Oil as a Multimodal Therapy for Neuropathic Pain: Investigating the Mechanisms of Action in Rats with Chronic Constriction Injury

et al. 2023

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“…In addition, barbiturates and benzodiazepines are commonly used. The effects of barbiturates and benzodiazepines on the central nervous system are mediated by interactions with the GABA receptor [ 7 ]. However, early antidepressant treatment may not provide adequate relief for the patient, due to the drug’s adverse effects of the drug or its lack of instant efficiency.…”

Section: Introductionmentioning

confidence: 99%

Rutin Improves Anxiety and Reserpine-Induced Depression in Rats

et al. 2022

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Mental disorders have a poor clinical prognosis and account for approximately 8% of the global burden of disease. Some examples of mental disorders are anxiety and depression. Conventional antidepressants have limited efficacy in patients because their pharmacological effects wear off, and side effects increase with prolonged use. It is claimed that herbal medicine’s antioxidant capacity helps regulate people’s mood and provide a more substantial pharmacological effect. With this background, the purpose of this study is to investigate the effect of rutin on reserpine-induced anxiety and depression in rats. The animals were divided into groups of six rats each: normal control (water), a depression model, a rutin-treated rat model, and an amitriptyline-treated rat model. According to the results, 14 days of treatment with rutin, once daily, showed a modest antidepressant effect. This effect was mediated by increased serotonin, norepinephrine, and dopamine levels in cortical and hippocampal regions. The antioxidant and vasodilator properties of rutin may contribute to its antidepressant properties. According to this study, rutin has shown antidepressant effects by reducing antioxidant activity and acetylcholinesterase.

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Evaluation of Neuropharmacological Effects of Different Chemical Extracts ofFlemingia Stricta(Roxb.) Leaves

Cited by 2 publications

References 17 publications

Caraway Oil as a Multimodal Therapy for Neuropathic Pain: Investigating the Mechanisms of Action in Rats with Chronic Constriction Injury

Caraway Oil as a Multimodal Therapy for Neuropathic Pain: Investigating the Mechanisms of Action in Rats with Chronic Constriction Injury

Rutin Improves Anxiety and Reserpine-Induced Depression in Rats

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